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Neuropathophysiology - Chronic Neurological Problems
Pathology of the neural system
53
Physiology
Undergraduate 3
12/14/2013

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Cards

Term
What is hydrocephalus?
Definition
Excess CSF
Term
Name the two types
Definition
1. Obstructive
2. Communicating
Term
What is obstructive hydrocephalus?
Definition
CSF circulation is blocked
Term
(T/F) The aquaduct of sylvius is the most common spot for this block
Definition
True
Term
What 2 things can cause this blockage?
Definition
- Stenosis from a tumour or infection
Term
What occurs in communicating hydrocephalus?
Definition
Reabsorption of CSF by the subarachnoid villi is impaired
Term
What occurs because of this block?
Definition
Ventricles expand (causing the skull to flex in neonates)
Term
What results from this ventricle expansion?
Definition
Brain damage: lethargy, impaired balance, memory problems, incontinence
Term
How does a shunt help eliminate hydrocephalus?
Definition
Allows the CSF to drain, therefore reducing pressure
Term
What is the cause of spina bifida? Is it inherited or aquired?
Definition
- Failure of the bony processes of vertebrae to fuse
- Congenital defect
Term
What does this lack of fusion allow?
Definition
It allows herniation of the spinal cord
Term
Name the 3 types of SB
Definition
1. occulta
2. meningocele
3. myelomeningocele
Term
Describe SB occulta?
Definition
SB without herniation of the cord contents
Term
Describe SB meningocele?
Definition
SB with herniation of the meninges of the spinal cord and CSF only
Term
Describe SB myelomeningocele?
Definition
SB with herniation of the meninges of the spinal cord, CSF, as well as nerves
Term
Which is most dangerous? Why?
Definition
Myelomeningocele; because nerves are involved, so repair is more difficult and dangerous
Term
List the 3 aspects of the etiology/signs of SB?
Definition
1. Alpha fetoprotein leaks into amniotic fluid
2. Familial incidence
3. Folic acid deficiency
Term
When is a folic acid deficiency especially indicative of SB?
Definition
Especially before week 6 of gestation
Term
What are the 3 causes of cerebral palsy?
Definition
1. Genetic
2. Abnormal fetal formation
3. Infection/damage in the perinatal period
Term
What is the most common cause of CP?
Definition
Hypoxia in the perinatal period
Term
What can cause this?
Definition
Difficult delivery of the baby can cause:
1. Hemorrhage
2. Aspiration
3. Vascular occlusion
Term
(T/F) High bilirubin crossing the BBB also contributes to CP
Definition
True
Term
What two things can arise from this? How could each cause CP?
Definition
1. Premature shift from Fetal Hb to adult - not enough oxygen
2. Rh incompatibility - damage due to immunological attack
Term
What else can cause harm during the perinatal period? At what point does it cause the most harm?
Definition
Hypoglycemia of the brain; During birth
Term
What are the two signs of CP?
Definition
- Motor development delay
- Persistence of infant reflexes (moro)
Term
List the 3 types of impaired motor function seen. Which is most common?
Definition
- Diplegia
- Hemiplegia (most common)
- Quadraplegia
Term
What is diplegia?
Definition
Movement is affected symmetrically, on both sides of body
Term
What is hemiplegia?
Definition
Movement is affected asymmetrically, on one side of body
Term
What is quadriplegia?
Definition
Movement is affected in all 3 lymps
Term
What are the 3 types of CP?
Definition
1. Spastic
2. Dyskinetic
3. Ataxic
Term
What does spastic CP involve?
Definition
Damage to pyramidal tract development
Term
What characterizes this CP form?
Definition
- "scissors gate": on toes
- Hyperreflexia
Term
What does dyskinetic CP involve?
Definition
Damage to the extrapyramidal neurons, basal nucleus or cranial nerves
Term
What characterizes this CP form?
Definition
- Choreiform (jerky) involuntary movements
- Loss of fine control
Term
What does ataxic CP involve?
Definition
Damage to the cerebellum
Term
What characterizes this CP form?
Definition
Lack of balance and coordination
Term
What are seizure disorders?
Definition
Uncontrolled excessive neuron activity in the brain
Term
List characteristics of seizure disorders
Definition
- Lower neuron threshold
- Neuronal activity spreads, and ends spontaneously
- 75% of cases are people under 25%
Term
List the two etiological components of seizure disorders
Definition
- Genetic (maybe)
- Head injury
Term
List 4 precipitating factors of seizure disorders
Definition
1. Flashing lights
2. Alkalosis
3. Hyperglycemia
4. Fever
Term
What is status epilepticus?
Definition
When the brain is in a state of persistent seizure; recurrent seizures with LOC
Term
List 4 other complications of seizure disprders
Definition
- Hypoxia
- Hypoglycemia
- Acidosis
- Decreased BP
Term
What are the two types of general seizures?
Definition
1. Absence (petit mal)
2. Tonic/clonic (grand mal)
Term
List characteristics of petit mal
Definition
- brief loss of awareness, eyelid twitching, staring
- no memory of event
- more common in children
Term
List the 5 stages of grand mal seizures
Definition
1. Prodromal 2. LOC 3. Ictal 4. Clonic 5. Post -ictal
Term
What occurs in the prodromal stage?
Definition
Visual disturbances
Term
What occurs in the ictal phase?
Definition
- Tonic muscle contraction
- Expiration/clenched jaws
Term
What occurs in the clonic stage?
Definition
- Jerky contraction/relaxation events
- Incontinence
Term
What occurs in the post-ictal stage?
Definition
- Limpness
- Sleep
Term
List the properties of partial seizures
Definition

- No LOC but decreased awareness

- Repeated activity

- Unusual sensations (tingling, ringing, flashing)

Term
What is a jacksonian seizure?
Definition
A seizure that exhibits a progressive spread of clonic contractions
Term
List 3 treatments for seizures
Definition
- Anti convulsive drugs
- Sedatives
Term
What are the side affects of anti-convulsants?
Definition
- Low WBC
- Gingival hyperplasia
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