Term
| what are NMJ blockers aiming at |
|
Definition
|
|
Term
|
Definition
| NO effects: analgesia, amnesia, or hypnosis |
|
|
Term
|
Definition
| compete w/Ach at the alpha subunit, inactivating 1 of them |
|
|
Term
|
Definition
| Vecuronium, Rocuronium, Pancuronium |
|
|
Term
| disadvantage of vecuronium |
|
Definition
| long term use leads to a prolonged paralysis |
|
|
Term
| This steroid depends heavily on renal metabolism |
|
Definition
|
|
Term
| Benzylisoquinolinium cmpds |
|
Definition
| Cisatracurium and Mivacurium |
|
|
Term
| Benz w/shorter half life: Miva or Cisa |
|
Definition
|
|
Term
|
Definition
Hoffman degradation
Ester hydrolysis |
|
|
Term
|
Definition
|
|
Term
|
Definition
| histamine release at high dose |
|
|
Term
|
Definition
| binds to both Ach subunits causing muscle fasiculations. |
|
|
Term
| What is the NMB of choice for rapid intubation |
|
Definition
| Sch- prevents vomiting and aspiration |
|
|
Term
|
Definition
hyperkalemia
post op myalgia
incr. ICP
malignant hyperthermia
Ach like effects |
|
|
Term
| what are the two phases of blockade |
|
Definition
Phase I: prolonged depolarization (Sch)
Phase II: repolarized but blocked (NDNBs) |
|
|
Term
| mech of action for neostigmine, pyridostigmine and edrophonium |
|
Definition
neo and pyri- hydrolyzed by cholinesterase
edrophonium: forms an electrostatic bond to cholinesterase |
|
|
Term
| Onset time of cholinesterase inhibs from shortest to longest |
|
Definition
|
|
Term
| the most frequently used antimuscarinic drugs |
|
Definition
| Atropine (edrophonium) and glycopyrrolate |
|
|
Term
| This antagonizes Rocuronium |
|
Definition
|
|
Term
| what is malignant hyperthermia precipitated by? |
|
Definition
inhaled agents and Sch
hypermetabolism due to incr Ca release |
|
|
Term
| Treatment of hyperthermia |
|
Definition
|
|
