Term
APAP major side effect ?
NSAIDS major side effect?
Comment for non-opioid analgesic use in HA ?
What age should not use ASA? |
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Definition
APAP major side effect - Hepatotoxicity
NSAIDS major side effect - GI upset
Comment for non-opioid analgesic use in HA - Use < 15 days/month for HA to avoid rebound HA
What age should not use ASA - 16 and under |
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Term
Combination Analgesics (butalbital or codeine):
Side effects?
Use/month for HA? |
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Definition
Combination Analgesics (butalbital or codeine):
Side effects - Dependence, tolerance
Use/month for HA - <10 days/month |
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Term
Ergot derivatives
Side Effects?
Use/month in HA?
Contraindications |
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Definition
Ergot derivatives
Side Effects - Chest pain, tingling in extremities, paresthesias, cramps, vasoconstriction, dependence
Use/month in HA - < 10 days /month
Contraindications:
Pregnancy
HTN
Cardiac disorders
PVD
PUD
Renal/Liver disease |
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Term
Triptans
Side Effects?
Contraindications? |
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Definition
Triptans
Side Effects - Chest discomfort, paresthesias, throat symptoms
Contraindications:
- DO NOT use within 72 hours of potent 3A4 inhibitors including: clarithromycin, azole antifungals, ritonavir, nelfinavir etc.
Contraindicated in:
Pregnancy
sustained HTN
Ischemic disease
Basilar or hemiplegic migraine
Ergot derivatives or MAOIs (except naritriptan & eletriptan)
Contraindications? |
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Term
BBs
Side Effects?
Contraindications? |
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Definition
BBs
Side Effects - Impotence, hyperglycemia, bronchospasm, CHF, depression
Contraindications - Asthma, Heart Block, Insulin dependent diabetes, bradyarrhythmias, pregnancy |
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Term
CCB - Flunarizine
Side effects
Contraindications |
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Definition
CCB - Flunarizine
Side effects: Weight gain, EPS, depression
Contraindications: HoTN, HF, arrhythmia, Depression, EPS. Avoid in severe constipation, |
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Term
Topiramate
Side Effects
Comment regarding OC |
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Definition
Topiramate
Side effects: Tremor, dyspepsia, constipation, weight loss, kidney stones, paresthesias
May reduce effectiveness of OC, recommend contraceptive with at least 30 mcg estrogen |
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Term
Valproic Acid/Divalproex
Side Effects?
Comment? |
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Definition
Valproic Acid/Divalproex
Side Effects - Alopecia, weight gain, thrombocytopenia, polycystic ovary syndrome, hepatotoxicity, Edema
Comment - Teratogenic |
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Term
Carbemazepine & Oxcarbemazepine
Side effects
Effect on P450 |
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Definition
Carbemazepine & Oxcarbemazepine
Hyponatremia (moreso oxcarb), Rash, cognitive impairment, transient neutropenia, photosensitivity, blurred vision.
Oxcarb is better tolerated
Both are p450 inducers, moreso carb. |
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Term
Gabapentin
Side Effects?
Comment? |
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Definition
Gabapentin
Side Effects - Ataxia, vision changes, tremor, peripheral edema, weight gain
Comment - Not metabolized, can use in liver failure. |
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Term
Phenytoin
Side effects?
Note concerning OCs? |
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Definition
Phenytoin
Side effects - Ataxia, gingival hyperplasia, skin rash, coarse facial features with long term use.
Note concerning OCs - Increases their clearance... recommend use of multiple contraceptive methods and an OC with 30+ mcg estrogen |
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Term
Pregabalin -
Side effects? |
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Definition
Pregabalin -
Side effects - Peripheral edema, ataxia, diplopia, weight gain
*ALL SIMILAR TO GABAPENTIN |
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Term
| Antiepileptic Drugs in general monitoring |
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Definition
| Baseline CBC & LFTs, repeat in 4-6 weeks |
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Term
Ethosuximide
Side effect
Only real use |
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Definition
Ethosuximide
Side effect - GI upset
Only real use - Absence seizures |
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Term
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Definition
Vigabatrin
Side Effects - Depression, irreversible vision changes, may worsen absence seizures or produce myoclonus |
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Term
Phenobarbital/Primidone (Metabolized to phenobarbital, but has anti seizure properties)
Side Effects?
DIs? |
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Definition
Phenobarbital/Primidone (Metabolized to phenobarbital, but has anti seizure properties)
Side Effects - Skin rash, depression, diminished libido
DIs - potent inducer of p450, metabolism is inhibited by divalproex |
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Term
Lamotrigine
Side Effects?
DIs? |
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Definition
Lamotrigine
Side Effects - Rash, Insomnia
DIs - Divalproex/Valproic acid doubles level of lamotrigine |
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Term
| Which anti-epileptics increase clearance of OCs? |
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Definition
COPT
Carbemazepine, Oxcarbazepine, Phenytoin, Topiramate |
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Term
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Definition
| Reduced energy, Irritability, Depression |
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Term
|
Definition
BDZ Side Effects
Drowziness, dizziness, retrograte amnesia, depression, respiratory depression, dependence/withdrawal |
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Term
|
Definition
TCA Side effects
anticholinergic effects, weight GAIN, anorgasmia, posturan HoTN, sexual dysfunction, urinary retention, arrhythmias, confusion |
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Term
Serotonin Antagonists - Pizotifen & Methysergide
Side effects |
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Definition
Drowziness, weight gain, pulmonary fibrosis (methysergide)
Methysergide -Do not use with 3A4 inhibitors |
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Term
Lithium
Side effects
Comments/Contraindications |
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Definition
Lithium
Side effects - Tremor, polyuria, diarrhea, hypothyroidism, renal dysfunction
Comments/Contraindications - Monitor renal function, electrolytes as well as, thyroid function
Contraindicated in renal dysfunction, CHF, dehydration |
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Term
|
Definition
Chlorpromazine
Side Effect - HoTN |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
| Cyproheptadine - Weight gain drowziness |
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Term
|
Definition
| Constipation, allergic reactions, CNS depression |
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Term
|
Definition
Respiratory depression, Constipation, Seizures, Ortho HoTN
DO NOT take within 14 days of MAOI. caution with drugs that reduce seizure threshold eg. SSRIs TCAs Bupropion |
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Term
SNRIs - Venlafaxine & Duloxetine
SEs |
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Definition
| Insomnia, tremor, dry mouth, HTN, ataxia, hyperhidrosis, anorexia |
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Term
|
Definition
| Muscle Weakness, reduce seizure threshold additive CNS depression |
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Term
|
Definition
| Hepatotoxicity, muscle weakness |
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Term
| Prednisone SEs & Contraindications |
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Definition
GI upset, Hyperglycemia, Na retention, hypokalemia, hypocalcemia
Contraindications - PUD, diabetes |
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Term
|
Definition
| Dry mouth, hallucinations, HoTN, hepatotoxicity |
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Term
Quinine Sulfate SEs
Important DIs |
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Definition
Quinine Sulfate
SEs - Tinnitus, gait disturbances, visual impairment, thrombocytopenia, hypersensitivity rxns
DIs - p450 inhibitor & substrate |
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Term
| Dopamine Agonists - Bromocriptine, Pergolide, Pramipexole, Ropinirole |
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Definition
| Orthostatic HoTN, confusion, hallucinations, psychosis |
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Term
|
Definition
| Orthostatic HoTN, dyskinesias, hallucinations, confusion |
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Term
|
Definition
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Term
MAO-B inhibitors - rasagiline & selegiline
SEs |
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Definition
MAO-B inhibitors - rasagiline & selegiline
Confusion, hallucinations, dysinesia
Serotenergi |
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Term
| COMT inhibitor - Entacapone SEs |
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Definition
| Dyskinesia, anorexia, hallucinations, urine discoloration |
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Term
| Anticholinergic Agents - Benztropine, ethopropazine, procyclidine, trihexphenidyl |
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Definition
| Anitcholinergic effects - blurred vision, dry mouth, urinary retention, memory impairment |
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