Term
| What Drugs are used in the treatment of Huntington's Disease? |
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Definition
| For Depression: Fluoxetine Carbamazepine For Chorea: Chlorpromazine Haloperidol |
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Term
| What drug is used in the treatment of Amytrophic Lateral Sclerosis? |
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Definition
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Term
| What drugs are used in the treatment of Multiple Sclerosis? |
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Definition
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Term
| What areas of the brain are effected in Alzheimer's disease? What abnormalities present? |
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Definition
Cerebral Cortex, temporoparietal lobe including the hippocampus
amyloid plaques and neurofibrillary tangles, composed of misplaced proteins |
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Term
| The presense of what apolipoprotein isoform is a risk factor correlated with AD? |
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Definition
ApoE4
(ApoE2 is protective) |
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Term
| What is amyloid beta peptide? |
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Definition
an abnormal proteolytic byproduct of the transmembrane amyloid precursor protein.
abnormally folded AB accumulate in Brains of patients with AD |
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Term
| What does pharmacotherapy aim to do in the treatment of AD? |
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Definition
elevating cholinergic transmission
reducing glutamatergic transmission |
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Term
| What are the Acetylcholinesterase inhibitors used to treat AD? |
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Definition
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Term
| What is the action of the AChEase inhibitors? |
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Definition
| Centrally acting reversible AChEase inhibitors which lead to an increase in ACh levels |
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Term
| What AChEase inhibitor has the highest bioavailability? |
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Definition
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Term
| What AChEase inhibitors have CYP2D6/3A4 metabolism? |
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Definition
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Term
| What AChEase inhibitor has an FDA warning against use in mild cognitive impairment? |
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Definition
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Term
| What drugs are used to treat Huntington Disease related depression? |
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Definition
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Term
| What drugs are used to treat HD associated chorea? |
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Definition
| Dopamine Antagonists: Chlorpromazine Haloperidol |
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Term
| What agent is used in the treatment of ALS, how does it work? |
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Definition
Riluzole
Na channel block, and high-voltage activated Ca channel block to reduce glutamate release -> reduces NMDA receptor induced excitotoxicity and acts as a myorelaxant |
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Term
| What agent is used for remitting-relapsing forms of MS? |
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Definition
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Term
| What monoclonal antibody is used in the treatment of MS and Crohn's disease? |
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Definition
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Term
| What MS agent requires perscribing care givers and patients to be specifiacally registered with the manufacturer? |
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Definition
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Term
| What MS agent is designed to mimic myelin basic protien to act as a decoy? |
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Definition
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