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Neuro
CNS Tumors
53
Medical
Professional
01/07/2010

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Cards

Term
Most common intracranial adult tumor?
Definition
metastatic carcinoma
Term
What is the most common location for metastatic carcinomas of the brain?
Definition
axial location (grey/white junction)
Term
What does extra-axial brain tumor mean?
Definition
outside of the brain parenchyma
Term
What phakomotoses increases risk for meningioma's?
Definition
NF-2
Term
common age for meningioma's?
Definition
40-65 yo, female 2:1
Term
Common sites for meningioma's?
Definition
parasagittal, sphenoid ridge, spinal cord
Term
Treatment for meningioma?
Definition
surgical excision
Term
prognosis of meningioma?
Definition
good
Term
Growth characteristics of meningioma?
Definition
slow growing, benign, compresses brain, doesn't invade, well-circumscribed
Term
Cellular whorls of arachnoid cells are found in what tumor?
Definition
meningioma
Term
Bilateral schwannoma's indicate?
Definition
NF-2
Term
Treatment for schwannoma?
Definition
surgery
Term
Can schwannoma be removed without damaging nerve?
Definition
yes
Term
http://library.med.utah.edu/WebPath/CNSHTML/CNS187.html
Definition
Term
Antoni A is described as?
Definition
cellular with palisading nuclei (schwannoma)
Term
Antoni B is described as?
Definition
loose, less cellular areas (schwannoma)
Term
What is a verocay body and is found in what tumor?
Definition
intervening anuclear zone between palisading nuclei
Term
Circumscribed astrocytoma's are found at what site and in what age group?
Definition
midline tumors found especially in cerebellum and optic nerve and found in children/young adults
Term
Diffuse astrocytoma's are what grades?
Definition
II-IV
Term
Circumscribed astrocytoma known as?
Definition
juvenile pilocytic astrocytoma
Term
This slow growing tumor has elongated spindle-shaped astrocytes, hyper and hypodense areas with microcysts, and like other slow growing tumors can have Rosenthal fibers?
Definition
Juvenile pilocytic astrocytoma
Term
What do astrocytoma's usually stain positive for?
Definition
GFAP (glial fibrillary acidic protein)
Term
Grade II astrocytoma's look similar to normal neuropil but as grade increases what happens?
Definition
astrocyte proliferation, vascular proliferation, necrosis
Term
Grade IV astrocytoma aka?
Definition
glioblastoma
Term
glioblastoma's are histologically described as?
Definition
highly cellular, pleomorphic, hyperplastic vascularity (glomeruloid looking vascular proliferation), mitoses, and necrosis
Term
Going from low grade astrocytoma to high grade there are cumulative gene abnormalities, two of these include?
Definition
p53 mutations and Loss of heterozygosity of c'some 10
Term
what's the prognosis for glioblastomas?
Definition
6-12 months
Term
What's the prognosis for low grade astrocytoma's
Definition
10-15 yrs
Term
What type of response do diffuse astrocytoma's have to chemotherapy?
Definition
poor
Term
Site of oligodendrogliomas?
Definition
cerebral hemispheres
Term
This tumor is poorly circumscribed, infiltrative, hemorrhagic, and has focal calcification in the cerebral hemispheres with a prognosis of 5 year survival?
Definition
oligodendroglioma
Term
fried egg appearance with perinuclear halo appearance and calcifications are seen in this tumor?
Definition
oligodendroglioma
Term
Chicken-wire vascular pattern, identified with factor VIII ab seen in this tumor type?
Definition
oligodendroglia
Term
oligodendroglial tumors go through similar changes as what other tumor type to become malignant?
Definition
GBM
Term
Treatment for oligodendroglial tumor?
Definition
chemo and surgery
Term
Supratentorial ependymoma's found in what age group?
Definition
5-25 yrs
Term
Common presentation for ependymoma?
Definition
symptoms of CSF obstruction
Term
Common site for ependymoma's?
Definition
4th ventricle and spinal cord
Term
These tumors are granular and flake off easily which enables them to seed this area?
Definition
CSF pathways
Term
Perivascular pseudorosettes are key diagnostic features of this tumor?
Definition
ependymoma
Term
medulloblastoma's affect this patient population
Definition
pediatric
Term
In younger patients medulloblastomas are typically found here in young? here in old?
Definition
cerebellar vermis, lateral hemisphere of cerebellum
Term
Medulloblastoma's can seed this area?
Definition
CSF
Term
Small, round blue cell tumor in cerebellum?
Definition
medulloblastoma
Term
Rosette formation (blue cell tumor on pink neuropil fibrillary background) in this tumor?
Definition
medulloblastoma (other rosette's found in PNET)
Term
This can be found next to a variety of slow growing tumors?
Definition
Rosenthal fibers (pink beaded arrangement of astrocytic glial filaments)
Term
http://img.medscape.com/fullsize/migrated/439/170/nf439170.fig2.jpg
Definition
juvenile pilocytic astrocytoma (circumscribed astrocytoma)
Term
http://upload.wikimedia.org/wikipedia/commons/f/ff/Glioblastoma_(1).jpg
Definition
GBM
Term
http://www.ajronline.org/content/vol181/issue1/images/large/07_AC1286_01E_color.jpeg
Definition
oligodendroglioma
Term
Tumor with chicken-wire vascular pattern?
Definition
oligodendroglioma
Term
Tumor you think of when there are Perivascular Pseudorosettes?
Definition
Ependymoma
Term
Homer Wright type rosettes?
Definition
Medulloblastoma with blue cells
Term
http://moon.ouhsc.edu/kfung/IACP-OLP/APAQ-Images/N1-TU-01-17.gif
Definition
rosettes seen in medulloblastoma
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