Term
What is the mechanism of Methylphenidate
What are the adverse effects? |
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Definition
Block dopamine and some norepinephrine reuptake
Adverse
Anorexia
Insomnia
Cardiotoxic if underlying abnormality |
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Term
| What are the amphetamines used to treat ADHD and what is their mechanism of action |
|
Definition
Dextroamphetamine
Lisdexamfetamine
MOA: Enhances release and decreases reuptake of DA and NE |
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Term
| What is the structure of lisamfetamine and how must it be administered, and its duration of action |
|
Definition
lysine
PO only because degradation needed
8-12hrs |
|
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Term
| What is the mechanism of Atomoxetine, how is it used in ADHD and its adverse side effects |
|
Definition
Mech: Norepinephrine Reuptake inhibitor
2nd line if tolerance or resistance to Stimulants
Adverse: Anorexia,
Increase BP and Pulse Pressure
Hepatotoxicity |
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Term
| What is the mechaism of clonidine or guanfacine, which ADHD symptoms is it more effective at treating, and what are the adverse effects? |
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Definition
Alpha-2 adrenergic agonists
Symptoms: Impulsivity and Hyperactivity(Off label)
Adverse: Orthostatic Hypotension, Sedation |
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Term
| What is the mechanism of Bupropion? |
|
Definition
| Mechanism: Dopamine and norepinephrine reuptake inhibitor |
|
|
Term
|
Definition
Methylphenidate
Dexamphetamine
Atomoxetine
Bupropion
Clonidine/Guanfacine |
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