Term
| What is the PACE program and how is it used |
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Definition
| PA program subsidizing the cost of drugs for eligible elderly patients |
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Term
| What are some major problems in prescribing to geriatric patients |
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Definition
Compliance
Cost
Multiple drugs
Physiology |
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Term
| How is absorption affected in the geriatric patient |
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Definition
Less acid
Less motility
Thinner abdominal wall
Absorption is slightly greater but it will take longer |
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Term
| How does the fat mass of patients change as they get older and what are the effects on the pharmacokinetics |
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Definition
Increase in fat mass
Kinetics: Fat soluble drugs will last longer in the body |
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Term
| How does albumin levels change as you get older and what is the effect on prescribing to geriatric patients |
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Definition
Albumin levels decrease causing more free(active) drug
Geriatric patients require lower doses as they age and the drugs used should have less than 90% albumin binding capacity |
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Term
| What aspect of drug metabolism is typically reduced in geriatric patients |
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Definition
| Phase 1 Rxn's: oxidation, reduction and hydrolysis(unmasking or adding polar groups) |
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Term
| What is the normal creatinine level and why is this misleading in the geriatric patient? |
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Definition
1-2
Geriatric patients typically have reduced muscle mass show that the thresholds for evaluating kidney function should be lowered |
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Term
| Why do the pharmacodynamics change in geriatric patients and what is a typical drug that this change is present in? |
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Definition
Receptor Aging
Common in Beta receptors(B-blockers) |
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Term
| What medications should not be used long term in geriatrics |
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Definition
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Term
| What is the best way to quantify the amount of free drug in the body? |
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Definition
| Measure concentrations in the saliva |
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Term
| What is the most common drug that causes horizontal nystagmus |
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Definition
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