Term
| What are the general mechanisms to sensitizing Neurons |
|
Definition
Modulation: More Phosphorylation
Modification: More Receptors
Immune Sensitization |
|
|
Term
| What is the most common sign specific to neuropathic pain |
|
Definition
|
|
Term
| What are the first line drugs for neuropathic pain |
|
Definition
1st: AED-Carbamaxepine, Gabapentin, Pregabalin, Tolpiramate
TCA-Amitryptiline, Nortryptiline, Desipramine
SNRI's-Duloxetine, Ventlafaxine
Local Anesthetics
|
|
|
Term
| What is the effect of neuropathic pain on the somatosensory cortex |
|
Definition
|
|
Term
| What are the 2nd and 3rd line drugs used to treat neuropathic pain |
|
Definition
2nd: Muscle Relaxants-Baclofen, Cyclobenzaprine, Carisoprodol, Metaxolone
Canabinoids- Dronabinol, Nabilone, Sativex
Alpha-2 Agonist: Clonipine, Tizanidine
NMDA Antagonists: Dextromethophan, Ketamine
3rd Line: NSAIDs, Opiods
|
|
|
Term
| What are the major mechanisms to treat neuropathic pain |
|
Definition
Enhance Inhibitory
Inhibit Excitatory
Block Ion Channels
Block Biogenic Amine Reuptake |
|
|
