Term
| The extent of Alzheimer's dementia is correlated with what pathological lesions |
|
Definition
Neurofibrillary Tangles and
Loss of Synapses on EM |
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|
Term
| What is the composition of neuritic plaques |
|
Definition
| Extracellular Torturous neuritic processes |
|
|
Term
| What are neurofibrillary tangles |
|
Definition
| Intracellular inclusions of accumulated organelles(neurofilaments and microtubles) |
|
|
Term
| What are paired helical filaments |
|
Definition
| Hyperphosphorylated Tau Protein |
|
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Term
| What is the gross and micro appearance of alzheimer's? |
|
Definition
Gross: Widening Sulci, Thining Gyri, cortex atrophy in Frontal, Parietal, and Temporal lobes
Micro: Neuritic Plaques, Neurofibrillary tangles, Amyloid Angiopathy, Hirano Bodies |
|
|
Term
| What is alzheimer's amyloid and how is it produced? |
|
Definition
Formed by B-secretase cleavage of an Integral Membrane Protein forming insoluble oligomers
These A-Beta oligomers aggregate to form neurofibrils |
|
|
Term
| Describe the appearance of a Hirano Body? |
|
Definition
| Eosinophillic rod-shaped crystalline aggregates in hippocampal pyramidal cells |
|
|
Term
| What genes are linked to alzheimer's disease? |
|
Definition
Presenilin 1, Presenilin 2
Apolipoprotein E-allele (e4)
Amyloid Precusor Protein |
|
|
Term
| What are the signs of Pick's Disease and what areas of the brain are effected |
|
Definition
Personality Change: Anterior Frontal
Language: Lower Temporal
Atophy of Caudate and Putamen
|
|
|
Term
| What is the microscopic pathology of Pick's disease(Fronto-Temporal lobar degeneration) |
|
Definition
| Pick's bodies: stain postive in silver stain |
|
|
Term
| What is the gross and micro pathology of Parkinson's |
|
Definition
Gross:Locus Ceruelus Loss
Pars Compacta Loss
Micro: Lewy Bodies-eosinophillic surrounded by halos |
|
|
Term
| What drug is used to generate the model for parkinson's? |
|
Definition
|
|
Term
| What are the behavioral signs of Huntington's disease as the disease progresses? |
|
Definition
Initially motor symtoms and the onset of psychosis
Later there is severe dementia and movement disorders |
|
|
Term
| Describe the pathology of huntington's disease? |
|
Definition
Caudate>Putamen gliosis and neuronal loss
Frontal>Parietal Atrophy |
|
|
Term
| What are the familial forms of ALS |
|
Definition
SOD1 Autodominant
Alsin Autorecessive |
|
|
Term
Which motor neuron disease exhibits:
Spasticity and Muscle wasting?
Spasticity w/o Muscle wasting?
No Spasticity w/ Muscle Wasting? |
|
Definition
ALS: Spasticity with wasting
Primary Lateral Sclerosis: Spasticity w/o wasting
Progresive Muscular Atrophy: Muscle Wasting only |
|
|
Term
| What are the pathologic lesions seen in motor neuron diseases |
|
Definition
Bunina Bodies: Cytoplasmic accretations of neurofilaments
Anterior horn loss
Betx cell loss in Motor Strip |
|
|
Term
| What is Werdig Hoffmann Disease |
|
Definition
Motor Neuron disease symptomatic at birth
Poor Stuck, Cry, and very little movement |
|
|
Term
| In what disease is a variant of alzheimer's seen in |
|
Definition
|
|
Term
| What is Dementia Pugilistica and what are the microscopic findings |
|
Definition
Parkinson's like dementia commonly seen in older boxers
Micro: Neurofibrillary Tangles, no Plaques |
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