Term
| What is the pathogenesis of Toxplasmosis |
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Definition
Oocyst ingestion from undercooked meat of intermeadiate hosts
Trophozoites released spreding to brain, lung, heart, and eye causing Mono symptoms
Dormant Cyst formation
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Term
| What is the Pathogenesis of Cryptococcus |
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Definition
Fungal inhalation forms solitary lung nodule
Hematogenous spread to Meninges, skin, bone, brain(abcesses)
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Term
| What is the pathogenesis of Pneumocystis |
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Definition
Person to person or inhalation
Immunosupression permits diffuse interstitial pneumonitis |
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Term
| What is the pathogenesis of CMV |
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Definition
Asymptomatic infection spread through body fluids
Immunocomproprised:
Interstitial pneumonia
Chorioretinitis
Chronic Colitis
Congenital:
During Preg-> deaf and retarded
Preterm->interstitial pneumonia, hepatitis
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Term
| Describe the life cycle and transmission of Toxoplasmosis gondii to humans |
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Definition
Reservoir in cats: oocysts are excreted in feces
Oocyst ingestion forms tachyzoites(replicating form) and focal cysts of bradyzoites(dormant form) in tissues of intermeadiate hosts
Transmission: usually ingestion of undercooked meat of intermeadiate hosts
Other transmissions: Cat feces, Unfiltered water |
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Term
| Where does sexual reproduction of toxoplasma gondii take place |
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Definition
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Term
| Describe the clinical manifestations of CMV, Toxoplasmosis, Cryptococcus, and Pneumocystis infections in immunocompetent people |
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Definition
CMV: Asymtomatic, Mononucleosis
Toxoplasmosis: Asymtomatic, Mononucleosis
Cryptocoocus: Asymtomatic, Meningitis, solitary nodule<->diffuse infiltrate
Pneumocystis: |
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Term
| Describe the clinical manifestations of CMV, Toxoplasmosis, Cryptococcus, and Pneumocystis infections in immunocompromised people |
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Definition
CMV:
Interstitial Pneumonia,
Chronic Colitis,
Choreoretinitis
Toxomplasmosis:
Meningitis
Cerebral mass lesion
Chorioretinitis
Cryptococcus:
Pneumonia
Meningitis
Brain Abcesses
Pneumocystis:
Diffuse interstitial pneumonia |
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Term
| How are CMV, Toxoplasmosis, Cryptococcus, and Pneumocystis diagnoased |
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Definition
CMV: Histo-Owl's Eye, Seroconversion/IgM
Toxoplasmosis: Serconversion/IgM, clinical, biopsy
Cryptococcus: India Ink, Latex/EIA, SDA culture
Pneumocystis: Gomeri Stain(crushed Ping Pong Balls) or Giemsa stain(trophozoites)of fluid lavage |
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Term
| What is the main immune response against CMV, Toxoplasmosis, Cryptococcus, and pneumocytis? |
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Definition
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Term
| What type of toxoplasmosis gondii causes the most human disease and which type is most commonly found in animal reservoirs |
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Definition
Human Disease: II
Reserviors: III |
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Term
| What are the most common signs of cryptococcus infection |
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Definition
| Immunocompromised person with chronic headache progressively developing cognitive and behavior changes possibly seizures |
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Term
How does Cryptococcus appear 25 degrees
and what is it main virulence factor? |
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Definition
Not a Dimorphic Fungi
Mucopolysacchiride Capsule |
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Term
| What is the typical apearance of pneumocystis carinii infection on CXR |
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Definition
| Diffuse interstitial Pneumonitis with Ground Glass appearance |
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Term
| Leading cause of fungal meningitis |
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Definition
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Term
| What substance contains the highest concentrations of cryptococcus |
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Definition
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Term
| Which of the following can cause spontaneous abortions and disabilities for a child in-utero: CMV, TOxoplasmosis, Cryptococcus, or Pneumocystis? |
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Definition
Toxoplasmosis
Cytomegalovirus |
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Term
| What are some common features of Cytomegalovirus replication and what type of virus is it |
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Definition
Enveloped dsDNA like all Herpes Viruses
Imeadiate Early->Early-> Late Protein expression
Latency(like all Herpes Viruses) |
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Term
| Why does pneumocystis carinii respond to antibacterials and antiparasitics, but not to Anti-fungals |
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Definition
| Cell Wall lacks Ergosterol |
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