Term
| Describe the virus causign Subacute Sclerosing Panencephalitis? |
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Definition
| Mutated measules virus with altered M protein causign persistant infection |
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Term
| Describe the virus causing Progressive Multifocal leukoencephalopathy and the pathogenesis of the disease |
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Definition
JC virus: dsDNA
Respiratory infection with persistance in kidney
Immunosuppression allows dissemination to brain |
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Term
| What are the manifestations of BK virus |
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Definition
Kidney transplant loss
Urethral stenosis and cystitis in marrow transplants |
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Term
| Why is serology not used to diagnose SSPE |
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Definition
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Term
| What are some indication from the history and CSF of SSPE? |
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Definition
measule before age 2
10-15 yr incubation
CSF Lymphocytosis |
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Term
| What is the pathogenesis and resulting pathology of creutzfeld-Jakob Disease |
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Definition
Ingestion of PRPsc(B-sheet) from infected animals products
PRPc (Alpha helical form localized in the brain) dimerises with the abnormal PRPsc and is converted PRPsc conformational form
PRPsc propagation causes amyloid plaques, fibrils, and vacuolation of neurons (spongiform) |
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Term
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Definition
Shivering or Jerky movements(Myoclonus)
Progressive dementia |
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Term
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Definition
Clinical
vCJD: biopsy of tosil tissue |
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Term
| Is there a genetic suseptibility to CJD |
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Definition
| Homozygousity at codon 129 for PRP protein |
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Term
| What are some other prion diseases besides CJD |
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Definition
Kuru: Fore Tribe in New Guinea, no dementia
Gerstmann-Straussler-Scheinker Syndrome
Fatal Famial Insomnia |
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Term
| Does CJD cause pathology by immune-mediated mechanisms |
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Definition
| No, just the protein aggregates themselves |
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