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Details

Neuro/Psych-Micro
Persistent Infections of the CNS
11
Microbiology
Graduate
01/12/2011

Additional Microbiology Flashcards

 


 

Cards

Term
Describe the virus causign Subacute Sclerosing Panencephalitis?
Definition
Mutated measules virus with altered M protein causign persistant infection
Term
Describe the virus causing Progressive Multifocal leukoencephalopathy and the pathogenesis of the disease
Definition

JC virus: dsDNA

Respiratory infection with persistance in kidney

Immunosuppression allows dissemination to brain

Term
What are the manifestations of BK virus
Definition

Kidney transplant loss

Urethral stenosis and cystitis in marrow transplants

Term
Why is serology not used to  diagnose SSPE
Definition
No Ab to the M protein
Term
What are some indication from the history and CSF of SSPE?
Definition

measule before age 2

10-15 yr incubation

CSF Lymphocytosis

Term
What is the pathogenesis and resulting pathology of creutzfeld-Jakob Disease
Definition

Ingestion of PRPsc(B-sheet) from infected animals products

PRPc (Alpha helical form localized in the brain) dimerises with the abnormal PRPsc and is converted PRPsc conformational form

PRPsc propagation causes amyloid plaques, fibrils, and vacuolation of neurons (spongiform)

Term
What are signs of CJD
Definition

Shivering or Jerky movements(Myoclonus)

Progressive dementia

Term
How is CJD diagnosed
Definition

Clinical

vCJD: biopsy of tosil tissue

Term
Is there a genetic suseptibility to CJD
Definition
Homozygousity at codon 129 for PRP protein
Term
What are some other prion diseases besides CJD
Definition

Kuru: Fore Tribe in New Guinea, no dementia

Gerstmann-Straussler-Scheinker Syndrome

Fatal Famial Insomnia

Term
Does CJD cause pathology by immune-mediated mechanisms
Definition
No, just the protein aggregates themselves
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