Term
| Direct-acting muscarinic agonists |
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Definition
Acetylcholine chloride
Methacholine
Carbachol
Bethanechol
Cevimeline
Pilocarpine |
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Term
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Definition
opthalmic
miosis, short acting |
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Term
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Definition
longer duration
bronchoconstriction |
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Term
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Definition
miosis
decreases intraocular press->contract ciliary m. which opens angle |
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Term
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Definition
use: excrete urine
caution: asthma (bronchoconstriction)
hyperthyroid (heart is sensitive)
peptic ulcers (acid secretion) |
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Term
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Definition
use: for drymouth, dec lacr/saliv
SE: all heart mechanisms decr
Vasodilation, reflex tachy-> stim M3 on vasculature
SLUDGE |
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Term
|
Definition
use: miosis, open angle (glaucoma)
CNS effects: can cross BBB |
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Term
Indirect-acting cholinergic agonists
(cholinesterase inhibitors) |
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Definition
| keep ACh from being broken down->prolong |
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Term
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Definition
Edrophonium
Tacrine
Donepezil
Rivastigmine
Galantamine
Memantine (not AChEI) |
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Term
|
Definition
binds anionic site
use: Dx myasthenia gravis
Nicotinic at NMJ |
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Term
|
Definition
use: Alzheimer's
hepatotoxic |
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Term
|
Definition
Use: Alzheimer's
not short-acting |
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Term
|
Definition
| SE: severe vomiting, esophageal rupture |
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Term
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Definition
Use: Alzheimer's
Incr mortality rate? |
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Term
|
Definition
not an AChEI
Use: Alzheimer's
blocks glutamate receptors->incr intracell Ca->overstim->cell death |
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Term
|
Definition
Pyridostigmine
Ambenonium
Guanidine |
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Term
|
Definition
Carbamoylates AChE->more stable
Use: myasthenia gravis |
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Term
|
Definition
accumulates in body
Use: myasthenia gravis |
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Term
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Definition
Use: myasthenia Eaton-Lambert syndrome
IgG Ab to Ca channels
Mech: prolongs ACh release, slows repolar. |
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Term
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Definition
Organophosphates
irreversible inhibitors->P's AChE
Rx-enzyme AGES->loses alkyl->more stable |
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Term
|
Definition
binds both sites
use: glaucoma
muscarinic |
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Term
|
Definition
lotion for head lice
binds to Sulfur in hair |
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Term
|
Definition
DUMBBELSS: hyper-parasymp effects
Tx Muscarinic: atropine
Nicotinic: pralidoxime (2-PAM)
-binds P of P'ing enzyme>frees enzyme
Duodote: treats both
Must give before AGING occurs
Chronic can cause axon degen |
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Term
|
Definition
kills lice
excites insect CNS, exhaustion/death |
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Term
|
Definition
blocks PSNS activity
Atropine
Scopolamine
Caution for GLAUCOMA bc it relaxes ciliary body->blocks aqueous flow
antidote for organophosphates |
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Term
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Definition
belladonna, deadly nightshade
used as mydriatic, cycloplegic |
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Term
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Definition
penetrates CNS better
used for motion sickness
SE: sympathetic activity |
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Term
|
Definition
Cyclopentolate
Tropicamide |
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Term
|
Definition
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Term
|
Definition
Darifenacin
Flavoxate
Solfenacin |
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Term
|
Definition
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Term
|
Definition
Stim Nn receptors
causes initial incr in BP and CO
-CA release from adrenal medulla
HR incr only slightly
Stim PSNS |
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Term
|
Definition
Ganglionic block
decr BP, peristalsis
Incr alertness from NE in cortex |
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Term
|
Definition
| treats nicotine addiction by inhibiting NE uptake |
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Term
|
Definition
partial agonist of a4B2 Nn receptor
Decr DA release
SE: nausea, HA, sleep disturbances |
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