Term
Epi- low dose
Preferentially stimulates?
Effect on vessels to muscle?
Effect on heart? |
|
Definition
β receptors
Dilates vessels to muscle/liver
↑ HR, CO with little change in BP |
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Term
Epi- high dose
Preferentially stimulates?
Effect on vessels to muscle?
Effect on heart?
Clinical use?
Caution? |
|
Definition
α receptors
Vasoconstriction
Baroreflex keeps HR from incr high
↑ CO, BP w/o stressing heart
Used w/ local anesthetics
Caution if hyperthyroid, ↑ β1 receptors |
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Term
Norepi
Preferentially stimulates?
Effect on vessels to muscle?
Effect on heart?
Clinical use?
Caution? |
|
Definition
Mostly α
Vasoconstriction
↑ BP
Use for shock, hypotensive state
Caution: ↓ in renal blood, hyperthyroid |
|
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Term
Dopamine- low dose IV ONLY
Mechanism?
Net effect?
Use? |
|
Definition
stimulate renal DA D1 receptors
↑ renal blood flow
Doesn't ↑ survival so OBSOLETE |
|
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Term
Dopamine- med dose
Mechanism?
Net effect?
Caution? |
|
Definition
stimulate renal D1 AND cardiac β1
↑ RBF, BP & CO
↑ chance of arrythmia compared to NE |
|
|
Term
Dopamine- high dose
Mechanism?
Net effect?
Caution? |
|
Definition
stimulate renal D1, cardiac β1 AND α1/2
Massive vasoconstriction
Monitor renal function |
|
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Term
|
Definition
nausea- Stim DA recept in area postrema
arrhythmias
few CNS side effects– doesn’t cross BBB |
|
|
Term
|
Definition
|
|
Term
|
Definition
α1 selective nasal spray decongestant
Vascoconstriction |
|
|
Term
|
Definition
α1 agonist for shock
↑↑ BP |
|
|
Term
|
Definition
Prodrug- Met to α1 agonist for orthostatic hypotension
urinary incontinence |
|
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Term
|
Definition
α2 agonist
-opens postsynaptic K+ channels→ K+ efflux, hyperpolarization
-inhibits presynaptic Ca2+ channels→ decr. NE release
Net effect: ↓ peripheral resistance, HR, CO
Disc. slowly to avoid flood of SNS act.
Sexual dysfunction in men |
|
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Term
|
Definition
α2 agonist
USE: GLAUCOMA
Decreases production of aqueous humor |
|
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Term
|
Definition
a2 agonist, opthalmic
Side effects: hypotension, palpitations due to inhibition of SNS outflow |
|
|
Term
|
Definition
parasympathetic dominates
Lowers BP |
|
|
Term
|
Definition
|
|
Term
|
Definition
inhibits smooth muscle contractions
↑ HR, CO |
|
|
Term
|
Definition
Oral, binds α1/α2– irreversible
Pheochromocytoma - tumor of the adrenal medulla -> excessive secretion of CAs
-EPI reversal
-Prostate & bladder obst- relax sphinct
Side effects: postural hypotens, tachy |
|
|
Term
|
Definition
inhibits α1 & α2 receptors
similar to phenoxybenzamine but faster |
|
|
Term
|
Definition
not α antagonist but also used for pheochromocytoma
inhibits TH |
|
|
Term
|
Definition
Blocks α1 in arterioles & veins -> ↓ peripheral resistance & venous return
USE: hypertension, add diuretic
1st dose effect- post. hypot./ syncope due to compens. tachycardia |
|
|
Term
|
Definition
"EROL"
sympathetics dominate
inhibits histamine release (↓ inflamm) |
|
|
Term
|
Definition
| vasodilation, ↑ HR, CO w/ slight ↓ BP |
|
|
Term
|
Definition
↑ CO
ADV. vs isoproterenol: ↓ effect on HR |
|
|
Term
|
Definition
β2 agonist for oral & inhalation
Mg2+ ↑s bronchodilation
Antagonizes Ca
Caution: can delay labor |
|
|
Term
|
Definition
| β2 agonist for inhalation |
|
|
Term
|
Definition
inhalation only, longest acting
NOT for acute attacks b/c long onset |
|
|
Term
|
Definition
anti-sympathetic
HR, BP, CO all ↓
Won't allow brochodialation
Can lower blood sugar- diabetic caution
-Hypoglycemia --> tachycardia
Won't be able to see if taking B blocker
SE: bradycardia, fatigue
Discontinue slowly |
|
|
Term
|
Definition
local anesthetic bc blocking Na+ channels
USES: arrhythmias, MI, HTN |
|
|
Term
|
Definition
Long acting
Uses: hypertension, angina |
|
|
Term
|
Definition
SELECTIVE β1 BLOCKER
HTN, angina, MI |
|
|
Term
|
Definition
SELECTIVE β1 BLOCKER
HTN, angina, MI |
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