Term
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Definition
Phenytoin has a variable half life. Neonates t1/2=21 hr, children
t1/2=2-20 hr, adults t1/2=11-29 hr. Phenytoin may cause cardiac arrhythmias,
blood dyscrasias and CNS symptoms. Many drugs of the “seizure class” are used
to treat psychiatric symptoms in children. Phenobarbital can cause paradoxical
hyperactivity in some children. |
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Term
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Definition
methylphenidate (long acting forms available) has been
associated with cardiac toxicity, appetite suppression and insomnia |
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Term
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Definition
SSRI for depression have been associated with increased
risk of suicide, other adverse effects; insomnia, GI symptoms, withdrawal
reaction if abruptly discontinued |
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Term
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Definition
mild pain use acetaminophen or ibuprofen avoid the use of
aspirin due to the possibility of Reyes syndrome,
Morphine for severe pain use appropriate age/weight corrected dosages |
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Term
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Definition
screen for alcohol, marijuana, other drugs of abuse, inhalants,
steroids, OTC and herbal products, cigarette smoking, internet-based products |
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Term
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Definition
| prevent CNS complications of diseases, meningococcal vaccine |
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Term
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Definition
| drug prepared in alcohol based solution |
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Term
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Definition
| un-dissolved particles of drug in vehicle, shaking required |
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Term
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Definition
decreased drug metabolizing enzymes
Cytochrome p450 60% of adult levels
Phase 1 – oxidative, demethylation, hydrolysis
Phase 2 – glucuronidation, conjugation, sulfonation |
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