Term
| anitbodies against pre-synaptic volage sensitive Ca++ channels: |
|
Definition
| Lambert-Eaton Myasthenic Syndrome (LEMS) |
|
|
Term
| among pts >40yo with LEMS 70% of men and 40% of women have this |
|
Definition
| underlying CA (usually lung Ca) |
|
|
Term
| LEMS is associated wtih fatigability of these mm |
|
Definition
|
|
Term
| which is more affected in LEMS upper or lower ext |
|
Definition
|
|
Term
| LEMS spares these mm often affected in other mm weakness d/o's |
|
Definition
| extraoccular mm and bulbar (speech, swallow, etc.) |
|
|
Term
| anti-acetylcholine receptor Ab |
|
Definition
|
|
Term
| aggrevating factors of mm weakness in myasthenia gravis: 4 |
|
Definition
1. worse in PM
2. worse with ecertion
3. worse with menses
4. worse with excitement |
|
|
Term
| occular involvement in myasthenia gravis |
|
Definition
| occular mm involvement is bilateral and asymmetric with ptosis and diplopia |
|
|
Term
| difficulty with repetitive movements; combing hair, lifting repeatedly, walking, running, climbing stairs |
|
Definition
|
|
Term
| proximal or distal weakness in myasthenia gravis |
|
Definition
|
|
Term
| 66% of myasthenia gravis patients have this anomally |
|
Definition
|
|
Term
| proximal mm weakness with mm enlargement, myalgias, slow relaxation of reflexes and CPK 100x nml |
|
Definition
|
|
Term
| describe infectious myositis |
|
Definition
| viral (flu, URI) myalgias and proximal mm weakness with >CPK and abn EMG, risk of rhabdo, self limiting dz |
|
|
Term
| infections most associated with guillian barre : 5 |
|
Definition
1. capylobacter
2. mono
3. CMV
4. herpes
5. mycoplasma |
|
|
Term
|
Definition
| initially LBP with pins-needles in feet then after 1-2d progress to mm weakness (MC is legs, then arms, face). sx evolve over 2-4wks without progression pst 4wks |
|
|
Term
|
Definition
| admit for risk of resp fail; moniter spirometry at bedside; FVC <15ml/kg = intubation. Tx c IVIG or plasmaphoresis |
|
|
Term
|
Definition
| 80-90% recover without disability |
|
|
Term
|
Definition
| chronic inflammatory demyelinating polyneuropathy |
|
|
Term
| risk factors for Amyotrophic lasteral sclerosis |
|
Definition
1. insectiside exp
2. smoking
3. gulf war veteran |
|
|
Term
|
Definition
|
|
Term
| upper motor neuron sx of ALS |
|
Definition
1. loss of dexterity
2. slowed movements
3. mm weakness
4. stiffness
5. emotional lability
6. hyperreflexia
7. +babinski |
|
|
Term
| lower motor neuron sx of ALS |
|
Definition
1. weakness
2. mm atrophy
3. fasciculations
4. cramps |
|
|
Term
|
Definition
1. diff c chewing
2. swallowing
3. speaking
4. tongue |
|
|
Term
| ALS: weakness proximal of distal |
|
Definition
|
|
Term
| most common acquired inflammatory demyelinating dz |
|
Definition
|
|
Term
| relationship of MS to equator |
|
Definition
| prevalence increases with distance from equator |
|
|
Term
|
Definition
|
|
Term
|
Definition
| oligoclonal bands in CSF and >CSF IgG index (calculated with CSF IgG/alb and serum IgG/alb). MRI brain |
|
|
Term
|
Definition
numbness/paresthesias
weakness (foot-drop, dropping items)
fatigue, diplopia, vertigo, cognitive decrease |
|
|
Term
| focal inflammation of spinal cord |
|
Definition
|
|
Term
| time for onset of transverse myelitis |
|
Definition
|
|
Term
| etiology of trnasverse myelitis |
|
Definition
1. neuromyelitis optica
2. MS
3. post-infection/vaccine
4. systemic inflammation (HIV, SLE, other autoimmune) |
|
|
Term
| CSF of transverse myelitis |
|
Definition
| increased IgG and pleocytosis |
|
|
Term
| tx for transverse myelitis |
|
Definition
| 1000mg methylprednisone qd x 5d |
|
|
Term
| 4 types of inflammatory myopathies |
|
Definition
1. polymyositis
2. dermatomyositis
3. myositis associated with CA
4. inclusion body myositis |
|
|
Term
| male: female ratio for myositis |
|
Definition
|
|
Term
| bimodal peak for myositis |
|
Definition
|
|
Term
|
Definition
| inflammatory infiltrate on mm bx |
|
|
Term
| timing of onset and sx of myositis |
|
Definition
| over months with PROXIMAL mm weakness, myalgia, atrophy |
|
|
Term
| myositis with onset over years c proximal and distal mm weakness |
|
Definition
|
|
Term
| 30% of myositis have this mm group invloved |
|
Definition
| esophagus (dysphagia and aspiration) |
|
|
Term
| skin eruption with rash occuring before onset of myositis |
|
Definition
|
|
Term
| what % of myositis has cardiac involvement |
|
Definition
|
|
Term
| what are the associated malignancies with myositis |
|
Definition
1. lung
2. breast
3. colon
4. prostate
5. ovary |
|
|
Term
| serum markers for myositis |
|
Definition
|
|
Term
|
Definition
| prednisone 60mg until CPK to baseline |
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|
