Term
the main goal of Parkinson's is to increase _?
in what part of the brain? |
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Definition
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Term
what is the secondary therapuetic goal of PD?
thru what receptor? |
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Definition
decrease endogenous ACh actions
muscarinic |
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Term
| why can tyou adminster dopamaine directly?-3 |
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Definition
destoryed in GI
cant be absorbed
must be IV but even then cant cross BB |
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Term
what is the prodrug given as dopamaine?
what is the transproter for this across the BBB? |
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Definition
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Term
| limit intake of _ to increase l-dopa absorption in the intestine? |
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Definition
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Term
what is Levodopa always combined with?
why? |
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Definition
decarboxylase inhbitor
to decrease decarboxylation to dopamine too quickly |
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Term
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Definition
| nausea, hallucinaitons, hyoptension |
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Term
long term treatment with levodopa leads to?
specifiaccly? |
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Definition
motor complicaitons
on/off response fluctations
dyskinesia
freezing |
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Term
| what happens to therapuetic window with longer treatment of l-dopa? |
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Definition
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Term
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Definition
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Term
l-dopa shoul;d be taken with what the first few week?S
why? |
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Definition
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Term
| L-DOpa is excerted where? |
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Definition
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Term
| what is the decarboxylase inhibitor? |
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Definition
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Term
| what is the combo drug of carbidopa and L dopa? |
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Definition
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Term
| what is the drug of just carbidopa |
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Definition
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Term
COMT inhibitpors are used as what?
what are they used to decrease? |
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Definition
adjunct med
response fluctuations |
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Term
| what is the COMT inhibitor peripherally and centrally drug? |
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Definition
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Term
| what is the generic of Tasmar |
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Definition
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Term
| side effect of tolcapone-1 |
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Definition
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Term
| what test needs to be done for tolcapone? |
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Definition
| blood test for hepatic function |
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Term
| COMT inhibitor drug (just peripherally) |
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Definition
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Term
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Definition
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Term
which is more preferred tolcapone or entacapone?
why? |
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Definition
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Term
| what is the combo of ldopa, carbidopa, and entacapone |
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Definition
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Term
| side effects of entacapone-2 |
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Definition
| nausea, othrostatic hypotension |
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Term
| L dopa without being given with any other drug only has what % transported across the BB? |
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Definition
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Term
| what MAO isoenzyme is for the deamination of dopamine in the brain? |
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Definition
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Term
MAO- B inhibitor?
what is the other names for it-3 |
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Definition
selegline
eldepryl, emsam, zelapar |
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Term
| what meds effects can be decreased with selegline? |
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Definition
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Term
| what is usually the frist drug of choice for PD? |
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Definition
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Term
| what are the metabolites of selegline-2 |
|
Definition
amphetamine
methamphetamine |
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Term
| what 2 adminstraiotns of selegiline reduce the metabolites and so reduce side effects? |
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Definition
trnasdermal
orl disintegrating |
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Term
| this is the irreversible MAO-B inhibitor |
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Definition
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Term
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Definition
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Term
| how does rasagiline compare to selegiline |
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Definition
| Rasagiline has less side effects |
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Term
for the two pathways that regulate movement, which does dopamaine stimulate and which does it inhibit?
what is the net response? |
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Definition
direct
indirect
pureposeful movement |
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Term
| when are dopamine agonists used? -3 |
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Definition
| initial therapies, young pts, adjunst to l dopa |
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Term
| what are the dopamine agonists now approved for monotherapy? |
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Definition
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Term
what is the duraiton of action for ropinirole?
is it well absorbed orally? |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| what other D recptors does the mirapex act on? |
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Definition
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Term
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Definition
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Term
what is the oldest and most potenet dopamine agonist?
what does it have highest affinty for? |
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Definition
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Term
| how is apo morphine administerred? |
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Definition
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Term
| what medd is the rescue med for ppl with intermitent off periods? |
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Definition
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Term
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Definition
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Term
| how is rotigotine adminsterred? |
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Definition
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Term
| what is the MOA of rotigotine? |
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Definition
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Term
how do anticholinergic meds help PD?-2
what symtpoms do they mostly treat? |
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Definition
block muscarinic recpt
block dopamaine reuptake
tremors |
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Term
depleted dopamine causes increased what?
why? |
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Definition
cholinergic activity
because D2 normally inhibits it |
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Term
| what are the anticholinergic meds? |
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Definition
benztropine
trihexyphenidyl |
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Term
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Definition
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Term
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Definition
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Term
what is the antiviral drug that cna enhance DA rlease and inhibit reuptake?
what other effects does it have?-2 |
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Definition
amantadine
blocks NMDA and has anti ACh |
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Term
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Definition
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