Term
| depression is cuased by deifiency of what NTs? |
|
Definition
|
|
Term
|
Definition
| less severe but longer lasting depression |
|
|
Term
|
Definition
| altering euphoric and irritable feelings |
|
|
Term
| MOA of TCAs in antidepression |
|
Definition
| block NT transporters which inhibits reuptake |
|
|
Term
| want NE slective compounds if patient is hvaing less happiness or less mtoivaiton? |
|
Definition
|
|
Term
what other drig class do TCAs cross over with?
why? |
|
Definition
antipsychotic
bc of structure |
|
|
Term
| what are the secondary amines for TCAs? -2 |
|
Definition
|
|
Term
do tertiary or secondary amine TCAs work better for increaisng serotonin?
qhat type of depression would they be best for? |
|
Definition
|
|
Term
| what is the chronic effect of 5HT receptors that cuases depression? |
|
Definition
| the presyantpic receptors decrease stimulation of the post synatpic receptors |
|
|
Term
TCAs also block what other recpetor
what are the side effects |
|
Definition
M1
tachycardia, urinary retentoin |
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|
Term
| do not combine TCAs with what toher drug class |
|
Definition
|
|
Term
| the sypathomimetic side effects of TCAs is due to |
|
Definition
|
|
Term
| the GI and sexual side effects of TCAs is due to? |
|
Definition
|
|
Term
| TCas also block this to cause lowering BP |
|
Definition
|
|
Term
| TCAs block H1 histamine- what are the effects? |
|
Definition
|
|
Term
| what 3 TCAs have high antihistamine effect? |
|
Definition
| doxepine, trimipramine, amitrypiline |
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|
Term
| MAOIs contain what motif? |
|
Definition
|
|
Term
| for MAOi, want covalent or noncovalent? |
|
Definition
|
|
Term
| what meds dont affect dopamine |
|
Definition
|
|
Term
|
Definition
phenelzine
transcycloprime |
|
|
Term
MAOis mainly inhibit what subtype?
does this cause more 5HT or NE |
|
Definition
MAO A
both are equally increased |
|
|
Term
| in healthy ppl, MAOis cause instant increase of what and delayed increase of? |
|
Definition
|
|
Term
|
Definition
central stimulation
orhtostatic hypotension
increase appetie and eight
atropine effects
liver tox |
|
|
Term
what subtype of MAO is found in the brain?
what are neuro meds mroe selctive for, A or B? |
|
Definition
|
|
Term
MAOi interaciotn with what substance?
why? |
|
Definition
tyramine
bc it normally metabolizes this, so there will be too much NE! |
|
|
Term
| too muhc tyramine means an ADR of what |
|
Definition
|
|
Term
MAOi patients must adhere too a strict what?
what medication class can they not be used with and why? |
|
Definition
dietary
TCAs bc of serotonin syndrome |
|
|
Term
| what OTC meds can cause high BP when used with MAOis |
|
Definition
|
|
Term
| appetitie suppressant with SRI combined with MAOi does what compared to a suppressant with an NRI? |
|
Definition
hyperthermia/serotonin syndrome
hypertension |
|
|
Term
| what drug classes cause hyperrthermia/serotonin syndrome with MAOis-3 |
|
Definition
antidepressants
appetitie suppresant
opoiods |
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