Term
| high/low hepatic clearence is what cna limit drug getting to brain? |
|
Definition
|
|
Term
| high/low protein binding makes it difficult fro drug to get to brain? |
|
Definition
|
|
Term
| main probelm for neuro drug development is what? |
|
Definition
|
|
Term
what is the Lipniski's rule of 5?
which one did Veber come up with |
|
Definition
MW<500
lopP<5
<5 H donors
< 10 H acceptors
<10 rotatable bonds;
the rotabale bond limit |
|
|
Term
| lipinski's rule of 5 only applies to what type of neuro drugs? |
|
Definition
|
|
Term
| Log P measures lipphilicty in the absence of what? |
|
Definition
| ionization (so drug is nuetral) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| sing non ring ond with non H terminal atom |
|
|
Term
| want more or less rotabale bonds for oral bioavilability |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| a high Log D means the drug is hydro/lipophillic |
|
Definition
|
|
Term
| are H bond donros or acceptors more limitng for crossing BBB? |
|
Definition
|
|
Term
what are the revised rule of 5 for BBB:
O and N atoms-
PSA-
log P
Mw
Log D |
|
Definition
O and N atoms <6
Clog P >0
PSA < 70
Mw- 450
log D 1-3 |
|
|
Term
| which type of moelcule is bad for BB- base or acid? |
|
Definition
|
|
Term
| selective or nonselctive inhibitoin of MAOi increases dopamine? |
|
Definition
|
|
