Term
| what are the chemical messengers of neurons? |
|
Definition
|
|
Term
| what are the 3 NTs that I never remeber |
|
Definition
|
|
Term
| what are the amino acid NTs? |
|
Definition
|
|
Term
| what are the catecholemine NTs? |
|
Definition
|
|
Term
| what Nts are classified as small molecules |
|
Definition
|
|
Term
| what is the neuropeptide NT? |
|
Definition
|
|
Term
| influx of what ion causes the vesicels to rlease NT? |
|
Definition
|
|
Term
| what is an example of metabotropic receptor? |
|
Definition
|
|
Term
| whcih receptor causes inhibiton of the NT release? |
|
Definition
|
|
Term
| What NTs are capabale of being reuptaken? -3 |
|
Definition
|
|
Term
| What substance is reuptaken by glial cells? |
|
Definition
|
|
Term
| what NTs are metabolized in the synaptic cleft?-2 |
|
Definition
|
|
Term
excitatory NT release causes the opening of what channels?
what do the inhibitory open? |
|
Definition
|
|
Term
| what depetermines the properties that contribute to receptor binding? |
|
Definition
|
|
Term
| what are examples of the properties of molecules to bind to receptors? -2 |
|
Definition
| hydrophobicity, ionoization |
|
|
Term
| what is another name for ionotropic receptors? |
|
Definition
| ligand gated ion channels |
|
|
Term
| what kind of proteins are invovled with the ligand ion channels? |
|
Definition
|
|
Term
which receptor type is made of only 1 subunit?
what NT binds here? |
|
Definition
|
|
Term
what type of recpetor has allosteric binding?
what does this mean? |
|
Definition
ionic
diff drugs can bind and block/open channel |
|
|
Term
what Nt doesnt cross BBB?
what does this mean? |
|
Definition
glutamte
neurons need to synthesize it |
|
|
Term
| what is glutamate synthesized from? |
|
Definition
|
|
Term
| what type of toxicity is there with glutamate? |
|
Definition
|
|
Term
| what types of receptors can glutamate bind to? what are the sepcific types of these classes? |
|
Definition
ionotropic and metabotropic
ionotropic: NMDa, non NMDA (AMPA, klaiante)
metabo: mGluR |
|
|
Term
| what is GABA synthesized from? |
|
Definition
|
|
Term
| what is the main inhbitory NT in brain? |
|
Definition
|
|
Term
an absense of GABA means what?
an ex of a disease state? -2 |
|
Definition
too muhc firing
anxiety and parkinsons's |
|
|
Term
what GABA receptor is ionotropic? -2
what is the other GABA recpt? |
|
Definition
|
|
Term
which GABA receptor has an antagonist?
wha about an agonist? |
|
Definition
|
|
Term
| what enzyme synthesizes ACh |
|
Definition
|
|
Term
| what 2 enzymes metabolize ACh in the synaptic cleft |
|
Definition
acytlecholinesterase
butrylchoninesterase |
|
|
Term
ACh can have what effects?
what is the majority? |
|
Definition
inhbitiory and excitatory
exictatory |
|
|
Term
what are the two receptors for ACh?
what type of receptor class are they? |
|
Definition
nicotonic & muscarinic
Nico: ionotropic
muscarinic: metabotropic |
|
|
Term
muscarinic recpotrs:
which are exictaotry
whcih are inhibitory? |
|
Definition
|
|
Term
what is the functoin of procholinergic drugs?
what diseas eis this used for?
what recpetors cna it act on? |
|
Definition
inhibit cholinesterases
alzhiemers
muscarininc or nicotinic |
|
|
Term
| what is hte function of anticholinergic drugs |
|
Definition
|
|
Term
| if have both alzheimers and parkinsons what drug class is contrainidcated |
|
Definition
|
|
Term
anticholinergic drugs function as what?
what disease state are they used in? |
|
Definition
muscarinic antagonists
parkinson;s |
|
|
Term
| what drug type is used for motin sickness |
|
Definition
|
|
Term
| what enzyme is the rate limitng step for dopamaine, Ne, and Epi synthesis? |
|
Definition
|
|
Term
| adrenergic recpeotes are also what recpetors? |
|
Definition
|
|
Term
what are the subtypes of metaobtropic recpetors?
which is assoc with glial and vascular cells and works on smooth msucles
which is assoc with neurons and vasoconst |
|
Definition
|
|
Term
| Alpha antagonist drugs are used for -3 |
|
Definition
|
|
Term
| B antagonists are used for- |
|
Definition
| Cardiovasc, migraines, glaucoma |
|
|
Term
| what med is used for nsala relief? |
|
Definition
|
|
Term
| what med is used for asthma? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| if you have a loss of dopamaine then get what disease? |
|
Definition
|
|
Term
what is the majroity dopamine pathway?
what does it control? |
|
Definition
|
|
Term
| what class are dopamine receptors? |
|
Definition
|
|
Term
what dopamine receptors are excititoary?
qhat are the inhibitory? |
|
Definition
|
|
Term
|
Definition
endocrine
motor contorl
behavioral |
|
|
Term
| what is the main recpetor for controlling behavior with dopamaine? |
|
Definition
|
|
Term
| drugs that increase DA are used for? |
|
Definition
|
|
Term
| drugs that inhibit DA are used as? |
|
Definition
|
|
Term
| serotonin is synthesized from? |
|
Definition
|
|
Term
| most serotonin receptors are what class? except for? |
|
Definition
|
|
Term
| how many subreceptors for serotonin are there? |
|
Definition
|
|
Term
| most hallucoinogens are what type of agonists? |
|
Definition
|
|
Term
| serotonin fucntoins as- 4 |
|
Definition
hallucinaitions
behavior change
sleep/wake
feeding |
|
|
Term
| this drug type is used for migraine treatment? |
|
Definition
|
|
Term
| this drug is used for migraine proph |
|
Definition
|
|
