Term
| the preferred route of drug administration |
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Definition
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Term
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Definition
released into bloodstream from intestines
alchohol-stomach-sooner
safe
unpredictability-type of food already ingested |
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Term
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Definition
strong fast predictable
subculaneous SM
intramuscular IM
intravaneous IV |
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Term
| addicts prefer which method of injection |
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Definition
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Term
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Definition
through capillaries in lungs
dose is hard to predict
damage lungs |
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Term
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Definition
nerual membrane of CNS
binding to particular synaptic receptor s
incluencing chain of chemical reaction in postsynaptic |
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Term
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Definition
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Term
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Definition
| eliminates a drugs ability to pass through fat mem of cells so it cannot pass through BBB |
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Term
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Definition
decreased sensitivity to drug
-less effect
-or more drug to reach origional effect |
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Term
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Definition
| tolerance is shirf to the right |
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Term
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Definition
| drug can produce tolerance to other |
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Term
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Definition
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Term
| drug tolerance categories |
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Definition
metabolic- changes to reduce amount of drug
functional-reactivity to sites |
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Term
| tolerance to psychoative drugs is largely |
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Definition
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Term
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Definition
adaptive neural changes
ex exposure can reduce number of receptors |
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Term
| what plays a major role in tolerance |
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Definition
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Term
| contingent drug tolerance |
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Definition
| demonstrations that tolerance develops only to drug effects that are actually experienced |
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Term
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Definition
| two groups of subjects recieve the same series of drug injections and the same series of repeated tests but the subjects in one group receive the drug before each test of tehseries and those in the other group reieve the drug after each test |
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Term
| situational specificty of drug tolerance |
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Definition
| the effect is large reliable and general |
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Term
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Definition
| external public stimuli such as the drug admin enviorment as the conditional stimuli |
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Term
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Definition
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Term
| ramsay and woods and drug tolerance |
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Definition
| the unconditional stimulus was the hypothermia directly produced by the exposure to alcohol while the compensatory changes that tended to counteract the reductions in body temp werethe unconditional response |
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Term
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Definition
| nicotinic cholinergic receptors in the brain |
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Term
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Definition
70% for smoking
10% alcohol
30% for heroine |
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Term
| heritability estimate for smoking |
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Definition
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Term
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Definition
| blood vessels become constricted |
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Term
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Definition
| agent that can harm a fetus |
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Term
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Definition
| small and soluble in fat and water |
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Term
| heritablilty estimate for alcohol |
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Definition
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Term
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Definition
increases production of urine in kidneys
alcohol |
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Term
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Definition
3rd phase which usually begins a day or two after the cessation of drinking and lasts 3,4 days
hyperthermia delusions tachycardia |
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Term
| alcohol affects the brain |
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Definition
reduces flow of calcium ions into neurons by acting on ion channels
interferes with the functionof second messergers inside neurons
it disrupst GABA and glutaminergic transmission
triggers apoptosis |
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Term
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Definition
| drug that interferes wiht the metabolism of alcohol and produces an accumulation in the bloodstream of acetaldehyde |
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Term
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Definition
short term mem is imparied
addiction potential is low
respiratory probs
tachycardia
more likely to b diagnosed wiht schizo |
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Term
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Definition
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Term
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Definition
| part of marajuana responsible for psychoactive affects |
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Term
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Definition
| 1rst endocannabinoid neurotrans to b isolated and charectorized |
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Term
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Definition
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Term
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Definition
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Term
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Definition
morphine codeine
bind to endorphin and enkephalin receptors
affective analgesics but addictive |
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Term
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Definition
| made it illegal to sell or use opium morphine cocaine but not heroin |
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Term
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Definition
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Term
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Definition
used to alleviate a heroin addiction
blocks the effect on the brain of other opiates without producting powerful euphoria |
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Term
| postitive incentive theory of addiction |
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Definition
| the primary factor in addiction is the craving for he positive incentive properties of the drug |
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Term
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Definition
| amount of pleasure from the experience of the drug |
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Term
| problems with regaining addiction |
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Definition
stress
drug priming-sample because they think they have control
enviormental cues |
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Term
| intracranial self stimulation ICSS |
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Definition
| self stimulation of shocks to the brain to their pleausre centers |
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Term
| mesotelencephalic dopamine system |
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Definition
| system of dopaminergic neurons that project from the mesencephalon into various region in the telencephalon |
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Term
| degeneration of what pathaway indicates parkinsons? |
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Definition
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Term
| many of the brian sites that self stimulation occurs is part of the |
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Definition
| mesotelencephalic dope system |
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Term
| intracranial self stimulation is assocaited with an increase in |
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Definition
| dopamine release in the mesocroticolimbic pathaway |
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Term
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Definition
| increase intracial self stimulation |
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Term
| lesions of the mesocorticolimbic pathaway |
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Definition
| disrupt intracranial self stimulation |
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Term
| lesions to either the nucleus accumbens or ventral tegmental area |
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Definition
| blocked the self admin of drugs into general circulaton or development of drug associated condtion place preference |
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