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Nervous Tissue
Morrow 1/26/11 lecture
92
Histology
Undergraduate 4
01/29/2011

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Term
G0, they are terminally differntiated
Definition
what phase of the cell cycle are all neurons in?
Term
soma/perikaryon
Definition
cell body, contains nucleus, surrounded by cytoplasm (2 names)
Term
Nissl substance
Definition
another name for rough ER, shows up as blueish spots around the nucleus
Term
lipofuscin
Definition
age pigment within the cell body
Term
golden
Definition
what color is lipofuscin?
Term
black or brown
Definition
what color is melanin?
Term
melanin
Definition
what gives the substantia nigra its color?
Term
CNS
Definition
where are most neuron cell bodies located?
Term
afferent
Definition
what kind of neurons receive stimuli from other neurons or the environment?
Term
1 or more
Definition
how many dendrites does a afferent neuron have?
Term
1
Definition
how many axons does an efferent neuron have?
Term
dendrite
Definition
highly branched neuron process?
Term
efferent
Definition
what kind of neuron transmits stimuli to other neurons or effector cells
Term
terminal bouton
Definition
what is the terminal distal swelling of an axon called?
Term
axon hillock
Definition
portion of the axon closest to the cell body
Term
multipolar
Definition
most common type of neuron
Term
motor neurons, interneurons
Definition
give two examples of multipolar neurons
Term
bipolar
Definition
what kind of neurons are the receptor cells of the retina
Term
bipolar neuron
Definition
single dendrite opposite single axon
Term
unipolar
Definition
no dendrites, axon only
Term
unipolar
Definition
sensory neurons are this kind of neuron
Term
pseudounipolar
Definition
single dendrite and axon fuse, soma off to one side
Term
synapse/neuromuscular junction
Definition
specialized junctions between neurons or between neuron and effector cell (like a muscle)
Term
uni
Definition
synapses are uni/bi/multi directional
Term
synaptic cleft
Definition
separates the terminal bouton and the effector cell
Term
mitochondria and membrane bound synaptic vesicles containing chemical neurotransmitters
Definition
what is found in the terminal bouton?
Term
pre-synaptic membrane
Definition
from what are signaling molecules released
Term
receptor molecules on the post-synaptic membrane
Definition
what do signaling molecules bind to once they diffuse across the synaptic cleft?
Term
[image]
Definition
pseudo-unipolar neuron
Term
[image]
Definition
multipolar neuron
Term
[image]
Definition
bipolar neuron
Term
GABA, dopamine, seratonin
Definition
list 3 neurotransmitter found in the CNS
Term
acetylcholine and norepinephrine(adreniline/epi)
Definition
what are the only neurotransmitters used in the PNS?
Term
sympathetic, parasympathetic
Definition
what are the two divisions of the PNS?
Term
sympatheric, adrenergic
Definition
fight or flight, uses adrenaline as excitatory neurotransmitter
Term
parasympathetic, cholinergic
Definition
promotes relaxation, uses acetylcholine as excitatory neurotransmitter
Term
hydrolytic and oxidative enzymes, ex: acetylchonlinesterase
Definition
what is contained in vessicles on the post-synaptic membrane?
Term
acetylcholinesterase
Definition
inactivates neurotransmitter between consecutive impulses-prevents continuous stimulation
Term
degradative enzyme
Definition
each neurotransmitter has its own ______. ex, acetylcholine has acetylcholinesterase
Term
it has an organo phosphate insecticide, which blocks acetylcholineesterase so neurotransmitters don't break down and cells are continuosly stimulated
Definition
how does RAID work?
Term
it prevents neurotransmitter degradation or mimics/binds to the acetylcholine receptor so it cannot be broken down, resulting in titanic convulsions
Definition
how does Nerve gas work?
Term
vicaine
Definition
what example of nerve gas was used in the subway in Japan?
Term
tetany
Definition
continuous stimulation of nerves results in this
Term
1) physical support and protection
2) electrical insulation
3) metabolic exchange
Definition
what do supporting cells provide (3 things)
Term
neuroglia-CNS
Schwann cells-PNS
satellite cells-ganglia
Definition
3 categories of supporting cells called, and where are each located?
Term
2, a pre-ganglionic/pre-synaptic and post-ganglionic/post-synaptic neuron
Definition
how many neurons connect the CNS to viscera in the ANS?
Term
gray matter of brain and spinal cord in the CNS
Definition
where are pre-ganglionic cell bodies located?
Term
ganglia
Definition
where are cell bodies of post-synatpic neurons located
Term
ganglia
Definition
discrete aggregations of neuron cell bodies located outside the CNS
Term
neural crest cells
Definition
what are ganglia and all peripheral nerves derived from?
Term
satellite cells-provides structural and metabolic support
Definition
what surrounds each neuron cell body in a ganglia? what do they do?
Term
parallel to the vertebral column
Definition
where are sympathetic ganglia located?
Term
in or near the effector organ
Definition
where are parasympathetic ganglia located?
Term
fibroblasts, dendrites? and axons?
Definition
what secretes collagen?
Term
prevertebral ganglia
Definition
sympathetic ganglia include _____ and paravertebral ganglia
Term
sympathetic trunk
Definition
where are paravertebral ganglia?
Term
anterior to the spine, ex: celiac and mesenteric plexi
Definition
where are pre-vertebral ganglia
Term
in or near effector organ, ex: between smooth muscle layers of the gut wall
Definition
location of parasympathetic ganglia
Term
afferent, efferent fibers (axons) of somatic, or autonomic neurons
Definition
what does peripheral nervous tissue contain? (4 things)
Term
axons only (enclosed in Schwann cells)
Definition
what do peripheral nerves consist of
Term
fascicles
Definition
bundle of multiple axons surrounded in perineurium
Term
unique, not just fibroblasts, exhibit epithelial and myeloid features
Definition
describe perineurium cells
Term
perineurium
Definition
what plays a major role in axon regenetation
Term
epineurium
Definition
large nerve trunks surrounded by an additional layer of CT
Term
endo, peri, epi
Definition
what is the order from inner to outer perineurium, epineurium, endoneurium
Term
blood vessels
Definition
tends to follow epi and perineurium
Term
neurilemma
Definition
another name for the sheath of schwann cells, consists mostly of cell membrane
Term
neurilemma
Definition
another name for the sheath of schwann cells, consists mostly of cell membrane
Term
several small nerve fibers lie in channels within the schwann cell , surrounded by a single layer of neurilemma (Plasma membrane) from Schwann cell
Definition
in non-myelinated nerve fibershow do Schwann cells interact with the nerve fibers?
Term
myelin sheath
Definition
large diameter neurons are insulated by this, which consists of many concentric layers of plasma membrane from many Schwann cells
Term
myelinated nerves have multiple layers of plasma membrane (of Schwann cells) surrounding them, but non-myelinated nerves have just one layer of cell membrane
Definition
compare myelinated axons to non-myelinated axons in terms of layers of cell membranes surrounding them
Term
Nodes of Ranvier
Definition
gaps in myelin sheath between adjacent Schwann cells
Term
saltatory conduction
Definition
name for rapid discontinuous conduction
Term
membrane depolarization occurs only at the nodes, not beneath Schwann cells
Definition
why is saltatory conduction faster and conserves elctrolytes?
Term
oligodendricytes
Definition
cells that myelinate neurons in the CNS
Term
bigger diameter of axons increases raot of conduction, also myelin
Definition
what increases the rate of conduction in nerve fibers?
Term
sodium, chloride
Definition
these ions are in higher concentration outside the cell
Term
potassium
Definition
this ion is in higher concentration inside the cell
Term
-80mV
Definition
according to morrow what is the net resting membrane potential inside the cell
Term
sodium potassium pump and potassium leak channels
Definition
what creates the positive outside charge and negative charge inside the cell?
Term
nervous conduction (electrical or chemical)?
Definition
arises in cell body as a result of an afferent stimulus
Term
nervous conduction
Definition
causes a region of the cell membrane to depolarize
Term
voltage gated sodium channels open, Na rushes into cell
Voltage gated K channels open, and K rapidly leaks out of the cell
Definition
when an action potential is reached, these channels open
Term
Na/K+ channels opening
Definition
what causes reversal of the resting potential
Term
depolarized
Definition
when the membrane loses polarity it is said to be ____
Term
1-2 msec
Definition
how long it takes for sodium channels to re-open once they close
Term
sodium channels closing
Definition
results in the refractory period where neurons are un-reactive to stimuli
Term
absolute
Definition
fist part of refractory period where response to stimulus is impossible
Term
relative
Definition
second part of refractory period where only a very strong stimulus can initiate depolarization
Term
after the Na channels close, voltage gated K+ channels close (ending the refractory period)
Definition
what happens to repolarize the membrane
Term
at the synapse via neurotransmitters
Definition
how and where is the action potential conducted to the effector cell
Term
stimulus, threshold, depolarization, action potential, repolarization, refractory period, resting state
Definition
put these in order refractory period, repolarization, stimulus, depolarization, repolarization, resting state, threshold
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