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Nervous System Organization and Terminology
Lecture 1
47
Other
Graduate
01/15/2010

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Term
What are the 6 major regions of the CNS?
Definition
1. spinal cord
2. medulla oblongata
3. pons and cerebellum
4. midbrain
5. thalamus and hypothalamus
6. cerebral cortex and basal ganglia
Term
What makes up:
1. mesencephalon
2. diencephalon
3. telencephalon
Definition
1. midbrain
2. thalamus and hypothalamus
3. cerebral cortex and basal ganglia, amygdala, hippocampus
Term
What components make up gray matter?
Definition
neurons, dendrites, unmyelinated axons and many glia
Term
what components make up the white matter?
Definition
myelinated axons
Term
In the CNS hows are neurons arranged in 1) gray matter and 2) white matter?
Definition
1. nuclei (clusters) and laminae (layers)
2. reticular formations (loosely interspersed)
Term
what is a neuronal system?
Definition
anatomically and functionally linked groups of neurons involving most or all regions of the CNS
Term
what does the CNS consist of?
Definition
it is a fluid filled tube surrounded by fluid kept in place by 3 meninges:
- brain, spinal cord, 12 cranial nerves, dorsal and ventral roots
- contains systems dedicated to both somatic and visceral (autonomic) function
Term
which part of the CNS is regionalized?
Definition
the brain; the spinal cord has almost no regionalization
Term
what is cephalization?
Definition
the formation of the brain and brain regions
Term
what area of the brain contains the outgrowths for the optic nerve and retina?
Definition
diencephalon
Term
[image]
Definition

1. olfactory organs

2. rostral choroid plexus

3. IIIrd ventricle

4. IVth ventricle

5. inner ear

6. caudal choroid plexus

7. spinal cord

8. medulla oblongata (myelencephalon)

9. cerebellum (metencephalon)

10. midbrain (mesencephalon)

11. eye

12. diencephalon

13. telencephalon

Term
[image]
Definition

1. choroid plexus of lateral ventricle

2. choroid plexus of IVth ventricle

3. IVth ventricle

4. cerebral aqueduct

5. IIIRd ventricle

6. lateral ventricle

Term
rostral = cranial = same as (anterior/posterior)?
caudal = tail = (anterior/posterior)?
Definition
1. anterior
2. posterior
Term
In most animals the CNS is a straight tube and position and orientation are straight forward. In humans this is complicated by what two factors?
Definition
1. upright posture leading to
2. downward shift of the foramen magnum
Term
the plane of thhe cranial fossae are oriented at parallel/right angles to the axis of the spinal cord
Definition
right angles
Term
The cephalic flexure at the level of the (1) causes the long axis of the pons and medulla to be aligned with the long axis of the (2)and the long axes of the diencephalon and telencephalon to be parallel/at right angles to the long axis of the spinal cord
Definition
1. midbrain
2. spinal cord
3. right angles
Term
What are the modern conventional terms of:
1. anterior horn
2. posterior columns
3. pons
4. superior colliculus
Definition
1. ventral horn
2. dorsal columns
3. anterior to the medulla (although it is dorsal or superior in anatomical position)
4. superior to the inferior colliculus but shoulld be described as ANTERIOR
Term
The white matter in the spinal cord, medulla, pons, and midbrain is found on the inside/outside. The white matter in the cerebral cortex, cerebellum, and diencephalon is found mostly on the inside/outside.
Definition
outside
inside
Term
Gray matter consists of? (3)
Definition
1. neurons and dendritic processes and axons
2. lots of non-neuronal cells like astroglia
3. lots of unmyelinated axons
Term
Where does most of the functional synaptic activity of the CNS occur? Where does most of the brain functional imaging show activity?
Definition
gray matter, gray matter
Term
How are neurons arranged in gray matter?
Definition
1. high density clusters called nuclei
2. in layers called laminae
3. loose, low-density arrangements scattered among fiber bundles
Term
All neurons are found in ______ but most cells in gray matter are _____ such as ____, ____, amd _____
Definition
gray matter, glia, astrocytes, oligodendroglia, microglia
Term
what is a nucleus?
Definition
cluster of neurons each which have their own cell nucleus; it is a collegction of functionally related neurons
Term
How are nuclei named?
Definition
1. nucleus ambiguous
2. by shape (amygdala -almond)
3. color (substantia nigra - black stuff, locus ceruleus - blue, globus pallidus - pale ball)
4. consistency (substantia gelatinosa - jelly-like substance)
Term
Where are neuronal laminae most likely to be found? and how many layers may be present?
Definition
1. cerebral and cerebellar cortices
2. 3-15 layers/sublayers of neurons
Term
What is a reticular formation?
Definition
neurons that randomly form clusters between nucleu; loose aggregations of nuerons scattered between more clearly defined nuclei
Term
Where are reticular formations likely to be found?
Definition
midbrain, diencephalon, pons, medulla, spinal cord
Term
More than ____% of the human CNS is white matter
Definition
60
Term
What is contained in white matter?
Definition
densely packed myelinated axons and their associated glia (oligodendroglia) connecting different nuclei and regions of the CNS; contains tracts
Term
what is a tract?
Definition
a tract is an individual bundle of white matter connecting different CNS regions and many nuclei named by origin and target of most of their axons or by shape
Term
what is a fasciculus or funiculus?
Definition
anatomically distinct and rounded bundle of white matter (longitudinal bundle) - contain tracts
Term
what is a commissure?
Definition
white matter tract that runs between two sides of the CNS such as the corpus callosum
Term
what is a lemniscus?
Definition
white matter tract in a crescent-shaped bundle
Term
what is a decussation?
Definition
crossing from one side of the CNS to other
Term
what is a peduncle?
Definition
a short, thick bundle of white matter
Term
what is considered essential knowledge for indentifying the location of CNS lesions? (3)
Definition
1. where a major tract is located in the region it traverses
2. knowing in which region a tract crosses
3. knowing the basic arrangement of acons in the major tracts; partial lesions can eliminate functions over one part of the body and not others
Term
No neuron is more than ____ synapses away from any other neuron in the CNS
Definition
4
Term
what is a synapse?
Definition
essential connecting specialization between neurons
Term
the CNS runs on a systems arrangement...what is the advantage? disadvantage?
Definition
advantage - high-level processing of info
disadvantage - once a system is damaged its particular function is lost
Term
Most connections between neurons are ______.
Definition
reciprocal (go both directions)
Term
Axons branch and most connections in the brain are organized in a ____ manner
Definition
parallel: A to B and C and B to C and A
Term
What are the three basic types of neuronal systems?
Definition
1. information-rich systems
2. regulatory
3. command
Term
What is an information rich system?
Definition
contain real world information with all sensory systems and major parts of the motor system; spatial organization of information; internal info goes to the hypothalamus
Term
What are 4 information rich systems?
Definition
somatotopy, retinotopy (visual), tonotopy (auditory), myotopy (motor)
Term
What are regulatory neuronal systems?
Definition
do not carry real world information but influence single-to noise ratio in sensory and motor systems and are involved in attention and consciousness. characterized by monamine neurotransmitters such as dopamine, serotonin, and noradrenaline. Also characterized by the widespread dispersion of axons of single cells
Term
What are command neuronal systems?
Definition
On the output side of the CNS and involved in turning on hard-wired circuits such as in walking
Term
what are 5 major properties of complex neuronal circuits?
Definition
1. dynamic
2. exhibit plasticity
3. generate patterns and rhythms
4. store info diffusely
5. can function after losing some elements
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