Term
Which two plasmodiums remain dormant in liver as hypnozoites?
How does this change treatment after exposure?
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Definition
P. vivax and P. ovale
Give Primaquin for these only.
(Treat hypnozoites) |
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Term
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Definition
| Stage of sporozoites in liver after division. A hepatic schizont that contains many merozoites and is ready to go to erythrocytes for real damage and rupture. |
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Term
| Sporozoites replicate in which part of the liver? |
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Definition
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Term
| Sequelae of malaria are seen after |
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Definition
| Rupture of RBC and release of merozoites from schizont |
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Term
| Are merozoites sexual or asexual |
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Definition
Both
Sexual become gametocytes which are reingested by mosquito after erythrocytic stage.
Asexual recycle in erythrocytic stage |
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Term
| Which plasmodium causes the most severe form of malaria and is also the most frequently drug resistant? |
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Definition
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Term
| Suppressive treatment of malaria is only effective against... |
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Definition
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Term
| Drug of choice for malaria eradication and suppression |
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Definition
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Term
| Side effects/Toxicities of Chloroquine |
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Definition
Reversible corneal damage and permanent retinal damage (bulls eye).
Visual disturbances, hyperexcitability, convulsions and heart block. |
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Term
| Drug of choice against Choloroquine-resistant plasmodium |
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Definition
| Mefloquine of doxycycline |
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Term
| Drug of choice against choloroquine and mefloquine resistant plasmodium |
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Definition
| Sulfonamide and Pyrimethamine (folate reductase inhibitor) |
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Term
| Which anti-malaria drug is contraindicated in patients with a history of epilepsy, psychiatric disorders, arrhythmias or cardiac conduction defect? |
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Definition
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Term
Which anti malaria drug is contraindicated in patients who are deficient in glucose-6-phosphate dehydrogenase or who have a history of granulocytopenia or methemoglobinemia?
Why? |
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Definition
Primaquine
Can cause hemolytic anemia in G6PD deficient.
Also should be avoided in those that have connective tissue disorders. |
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Term
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Definition
| Cinchonism: tinnitus, headache, nausea, visual disturbances |
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Term
|
Definition
| Folic acid anatagonist similar to Trimethoprim |
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Term
MOA of Atovaquone
Treats: |
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Definition
Disrupts mitochondrial electric transport in plasmodium
Treats malaria and pneumocytis jiroveci |
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Term
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Definition
| Inactive until converted to cycloquanil which inhibits plasmodium dihydrofolate reductase |
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Term
Best Line of Treatment
Asymptomatic E. Hystolytica
Symptomatic E. Hystolytica
Hepatic abscess in E. Hystolytica
T. Vaginalis
P. Jiroveci
T. gondii
G. Lamblia
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Definition
Iodoquinol (or diloxanide)
Metronidazole and Iodoquinol
Metronidazole and Iodoquinol
Metronidazole
TMP-SMX or Pentamidine
Pyrimethamine plus trisulfapyrimidines
Metronidazole
Pneumonic: For Metronidazole treatment of Protozoan infections:
GET it?
G iardia lamblia
E Entamoeba hystolytica
T richonomas vaginalis
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