Term
| What part of the nephron does childhood cystic disease affect? |
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Definition
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Term
| What part of the nephron does adult polycystic kidney disease affect? |
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Definition
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Term
| What are the complications of acquired renal cystic disease? |
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Definition
| risk of hemorrhage into cyst, renal cell carcinoma |
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Term
| what disease affects patients w/ESRD after many years of hemodialysis |
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Definition
| acquired renal cystic disease |
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Term
| what are the 2 types of acute tubular necrosis? |
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Definition
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Term
| what happens in ischemic acute tubular necrosis? |
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Definition
| loss of cell modifications (microvilli), cell swelling, pyknosis/karyolysis, apoptotic cell death |
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Term
| acidophilic inclusions in ATN |
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Definition
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Term
| mechanism of damage in ATN |
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Definition
| tubular obstruction by casts (sloughed epithel cells), tubular back leak from disrupted BM, vasoconstriction |
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Term
| fatty change in ATN indicates |
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Definition
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Term
| ballooning degen and oxalate crystal deposition in ATN indicates poisoning by |
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Definition
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Term
| When do you see renal pap necrosis with pyelonephritis? |
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Definition
| ischemic infarction, severe acute cases i.e. DM, leukocytic infiltration |
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Term
| When does interstitial nephritis occur? |
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Definition
| 2 wks after druge ingestion |
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Term
| What are the characteristic features of renal pap necrosis in interstitial nephritis? |
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Definition
| brown, diff stages of necrosis, bilateral, frequent calcification, better prognosis than diabetes |
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Term
| Name a metabolic disorder that affects the renal tubulointerstitium? |
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Definition
| gout- deposition of urate crystals(needle-like) in acidic milieu of distal renal tubules and interstitium |
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Term
| How does multiple myeloma affect the kidney? |
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Definition
| excretion of light chains in urine leads to bence jones proteinuria & cast nephropathy; LCs are directly toxic to renal epithel cells, so they form casts that obstruct tubular lamina |
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