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Details

Nephro Path
Tubulointerstitial Disease
15
Pathology
Graduate
11/01/2010

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Cards

Term
What part of the nephron does childhood cystic disease affect?
Definition
collecting tubules
Term
What part of the nephron does adult polycystic kidney disease affect?
Definition
all parts
Term
What are the complications of acquired renal cystic disease?
Definition
risk of hemorrhage into cyst, renal cell carcinoma
Term
what disease affects patients w/ESRD after many years of hemodialysis
Definition
acquired renal cystic disease
Term
what are the 2 types of acute tubular necrosis?
Definition
ischemic and nephrotoxic
Term
what happens in ischemic acute tubular necrosis?
Definition
loss of cell modifications (microvilli), cell swelling, pyknosis/karyolysis, apoptotic cell death
Term
acidophilic inclusions in ATN
Definition
Mercuric C1
Term
mechanism of damage in ATN
Definition
tubular obstruction by casts (sloughed epithel cells), tubular back leak from disrupted BM, vasoconstriction
Term
fatty change in ATN indicates
Definition
CCL4
Term
ballooning degen and oxalate crystal deposition in ATN indicates poisoning by
Definition
ethylene glycol
Term
When do you see renal pap necrosis with pyelonephritis?
Definition
ischemic infarction, severe acute cases i.e. DM, leukocytic infiltration
Term
When does interstitial nephritis occur?
Definition
2 wks after druge ingestion
Term
What are the characteristic features of renal pap necrosis in interstitial nephritis?
Definition
brown, diff stages of necrosis, bilateral, frequent calcification, better prognosis than diabetes
Term
Name a metabolic disorder that affects the renal tubulointerstitium?
Definition
gout- deposition of urate crystals(needle-like) in acidic milieu of distal renal tubules and interstitium
Term
How does multiple myeloma affect the kidney?
Definition
excretion of light chains in urine leads to bence jones proteinuria & cast nephropathy; LCs are directly toxic to renal epithel cells, so they form casts that obstruct tubular lamina
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