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Component of basement membrane.
Some in situ carcinoma cells have increased receptors to bind and further their ability to initiate invasion. |
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| Metalloproteinases and really produced mostly by fibroblasts and macrophages, which are stimualted to express and active them by cancer cell secretion of Emmprin. Represents cross talk between the tumor cells and the adjacent cells participates in this |
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Definition
| Type IV Collegenase that plays a critical role in the intial step of invasion of the basement membrane. |
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Definition
A GTPase when activated leads to the assembly of actin-myosin filaments into focal adhesion complexes that enhance motility in malignant cells.
"Rho, Rho, Rho your boat..." |
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Definition
Cross-links and bundles actin filamens enhancing tumor cell motility. Expressed at the invasive front but not in central regions.
"Fastens" actin filaments |
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Definition
| Inhibits Fascin and blocks cancer cell migration and invasion |
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