Shared Flashcard Set

Details

neoplasia I
cmbm exam V
30
Chemistry
Graduate
02/15/2010

Additional Chemistry Flashcards

 


 

Cards

Term
what is a neoplasia? tumor?
Definition
neoplasia means "new growth" tumor means swelling (not all tumors are neoplasms)
Term
how are benign tumors named?
Definition
cell type + -OMA (ex: adenoma = benign glandular tumor)
Term
how are malignant tumors named?
Definition
usually, carcinoma: of an epithelial cell origin (BUT melanoma breaks this rule). sarcoma: of a mesenchymal cell origin, (BUT lymphoma breaks this rule).
Term
what is a leiomyosarcoma?
Definition
leiomyo means smooth muscle, so leiomyosarcoma: malignant tumor of the smooth muscle
Term
what is different about adenomas in the colon?
Definition
they, aside from everywhere else have the potential to become malignant
Term
how are teratomas named? what do they have inside them?
Definition
tera- meaning like “terrible,” “monster-like” and "oma" meaning benign. they are commonly seen in the ovary and could have a tooth, hair, sebaceous material, brain, neuronal elements, thyroid tissue (there could be enough to cause hyperthyroidism)
Term
what does differentiation refer to? what help help determine it? how does it correlate with aggressiveness/prognosis?
Definition
differentiation refers to the extent which the tumor resembles the tissue of origin. it is possible to have an adenocarcinoma for example, that so poorly differentiated that its tissue of origin is unknown and generally poorly differentiated tumors have the worst prognosis b/c they are the most aggressive. staining can help determine tissue of origin.
Term
what is anaplasia?
Definition
lack of differentiation, very little or poor differentiation - generally assocated with aggressive tumors and poor prognoses
Term
what is pleomorphism?
Definition
pleomorphic tumors have cells with a variety of size and shape and are generally poorly differentiated
Term
what is the N/C ratio?
Definition
the nuclear/cytoplasmic ratio refers to the size of the nucleus relative to the cytoplasm, many tumors have large nuclei relative to the cytoplasm (due to constant growth and proliferation signals). a prominent nucleolus may be seen with the chromatin inside clumped and disorganized - numerous atypical nuclei w/abnormal chromatin patterns are also signs of malignancy
Term
what are mitotic figures?
Definition
cells dividing, malignant tumors are usually dividing rapidly and will have an abundant number of mitotic figures which may be tripolar, tetrapolar (and not bipolar)
Term
what is dysplasia? when is it seen in relation to a malignancy?
Definition
dysplasia is disorderly proliferation, many times dysplasia will proceed a malignancy
Term
how do benign tumors appear histologically?
Definition
cells are generally organized, they polarity: they are going in the same direction and the cells themselves are relatively uniform with normal n/c ratios
Term
what does the rater of tumor growth generally correlate with?
Definition
differentiation; poorly differentiated tumors will generally grow faster
Term
how do benign tumors appear/behave in terms of invasion?
Definition
benign tumors may be encapsulated and tend not to invade locally; they are well circumscribed and demarcated
Term
how do malignant tumors appear/behave in terms of invasion?
Definition
malignant tumors can penetrate and destroy tissue, with projections that begin to hold onto surrounding tissue
Term
what is the main defining characteristic of malignancy?
Definition
the ability to metastasize which is the most lethal aspect of cancer, you can't keep chasing and removing tumors all over the body
Term
how do benign tumors appear?
Definition
they are sharply demarcated from the surrounding tissue and have homogeneous surfaces (malignancies may have areas of necrosis and hemorrhage). histologically they could have a growth limiting capsule
Term
what are the mechanisms of metastasis?
Definition
seeding of body cavities, lymphatic spread, and hematogenous spread
Term
how does metastasis via seeding body cavities work?
Definition
for example: ovarian tumor gets large and ruptures, it can flood the peritoneum with tumor cells. this happens commonly with ovary, colon and CNS masses
Term
how does metastasis via lymphatic spread work? what tumors are associated with this? what is a caveat for these?
Definition
lymphatic spread is typical of carcinomas. example with breast CA: tumor grows in the breast, first place it would spread to would be the ipsilateral axillary lymph nodes (lymph nodes on same side of the breast). it is important to remove the tumor in sx, but also important to know which lymphatics are involved and sometimes remove them (pathologists can determine prognosis/tx by observing lymph node involvement)
Term
how does metastasis via hematogenous spread work? what tumors are associated with this?
Definition
hematogenous spread is usually through the blood, and typical of sarcomas; whose sites are often at the liver and lung. sarcomas sometimes have the ability to grow new blood vessels (angiogenesis), and hence are more likely to metastasize via hematogenous routes
Term
how might a malignat tumor appear?
Definition
not round and well-shaped, star-shaped/”stellate” appearance, malignant arms/claws that are grabbing the surrounding tissue
Term
where is a common location of metastasis?
Definition
the liver, where there are usually numerous metastases at once
Term
what are general characterisitics of benign tumors?
Definition
small, although some can be large and benign, well demarcated, well circumscribed, homogenous coloring, slow growing, non invasive, just pushing (pushing margins, does not grab surroundings and invade it, but just push away), well differentiated
Term
what are general characterisitics of malignant tumors?
Definition
large, poorly demarcated, rapid growth with hemorrage/necrosis (for a tumor to grow it needs a blood supply/vasculature. so if it is growing too rapidly it may outgrow its blood supply and become necrotic OR it may invade surrounding blood vessels and cause hemorrhage or bleeding). locally invasive, metastatic, poorly differentiated, and pleomorphisms are also seen
Term
what are factors in cancer formation?
Definition
environment (including nutrition/diet and smoking), age (DNA repair genes, tumor suppressor genes do not work quite as well), and heredity
Term
what are palpable characteristics of malignant tumors?
Definition
hard, irregular outline, poorly moble, fixed, usually painless, rapid growth, and systemic signs
Term
what are palpable characteristics of benign tumors?
Definition
soft, smooth outlines, freely moble, not fixed, +/- pain, slow growth, no systemic signs
Term
what are some different types of tumors?
Definition
well circumscribed, obscured, micro-lobuled, ill-defined, and speculated
Supporting users have an ad free experience!