Term
| These drugs block the 30s ribosomal subunit |
|
Definition
Aminoglycosides and tetracyclines
Buy AT 30 CELL at 50 |
|
|
Term
| These specific drugs disrupt fungal cell membranes |
|
Definition
| amphotericin B, nystatin, fluconazole/azoles (FAN the fungal cell membranes) |
|
|
Term
| What is the mechanism for penicillin type drugs? |
|
Definition
| Blocks bacterial cell wall synthesis by inhibition of peptidoglycan synthesis. |
|
|
Term
| This drug is used to suppress organ rejection, but may predispose patient to viral infections and lymphoma |
|
Definition
|
|
Term
| Signs of Lead poisoning include: |
|
Definition
| Lead Lines on gingivae and epiphyses of Long bones, Encephalopathy and Erythrocyte Basophilic stippling, Abdominal colic and sideroblastic Anemia |
|
|
Term
|
Definition
|
|
Term
|
Definition
| beta antagonist. Propranolol |
|
|
Term
|
Definition
| pituitary hormone. Somatotropin |
|
|
Term
| How does a noncompetitive inhibitor affect Vm? |
|
Definition
|
|
Term
| How does a noncompetitive inhibitor shifts the dose response curve? |
|
Definition
|
|
Term
| Azaothioprine is used to in what setting? (This is a cyclosporine) |
|
Definition
| Kidney transplants, autoimmune disorders (glomerulonephritis, hemolytic anemia) |
|
|
Term
|
Definition
| barbiturate. Phenobarbital |
|
|
Term
|
Definition
| butyrophenone (neuroleptic). Haloperidol |
|
|
Term
| Which drug blocks mRNA synthesis? |
|
Definition
| Rifampin blocks transcription |
|
|
Term
| Which drugs are the bacteriacidal antibiotics? |
|
Definition
| Penicillin, cephalosporin, vancomycin, aminoglycosides, fluoroquinolones, metronidazole |
|
|
Term
|
Definition
| cardiac glycoside (inotropic agent). Digoxin |
|
|
Term
| When would you use aminoglycosides? |
|
Definition
| Against severe gram-negative rod infections. |
|
|
Term
| What is the mechanism of action of Cephalosporins? |
|
Definition
| inhibit cell wall synthesis |
|
|
Term
|
Definition
|
|
Term
|
Definition
| methylxanthine. Theophylline |
|
|
Term
| How does a competitive inhibitor affect Km? |
|
Definition
|
|
Term
| These drugs block DNA topoisomerases |
|
Definition
|
|
Term
|
Definition
| antibiotic, protein synthesis inhibitor. Tetracycline |
|
|
Term
| How does a competitive antagonist shifts the dose response curve? |
|
Definition
| Shifts the curve to the right |
|
|
Term
| In 1st order elimination what is rate of elimination is proportional to? |
|
Definition
|
|
Term
|
Definition
| tricyclic antidepressant. Imipramine |
|
|
Term
| These drugs block nucleotide synthesis by interfering with the folate pathway |
|
Definition
| Sulfonamides (e.g. Bactrim), trimethoprim |
|
|
Term
| These drugs disrupt the bacterial/fungal cell membranes |
|
Definition
|
|
Term
| What's the main difference between a partial agonist and a full agonist? |
|
Definition
| A partial agonist has a lower maximal efficacy |
|
|
Term
| What are the main similarities/difference between 1st and 2nd generation cephalosporins? |
|
Definition
| 2nd gen has extensive gram neg coverage but weaker gram + coverage |
|
|
Term
| What should you watch out for when giving penicillin? |
|
Definition
| Hypersensitivity reaction (urticaria,severe pruritus) and hemolytic anemia |
|
|
Term
| Bacitracin, vancomycin and cycloserine block the synthesis of this molecule, preventing cell wall synthesis. |
|
Definition
|
|
Term
| What order of elimination is EtOH from the body? |
|
Definition
|
|
Term
| These drugs block the 50s ribosomal subunit |
|
Definition
| clindamycin, chloramphenicol, erythromycin, lincomycin, linezolid, streptogramins Buy AT 30 CELL at 50 |
|
|
Term
| How does a noncompetitive inhibitor affect Km? |
|
Definition
|
|
Term
| How does a competitive inhibitor affect Vm |
|
Definition
|
|
Term
| Which antifungal drug binds ergosterol? |
|
Definition
|
|
Term
| Which drug can cause Pseudomembranous Colitis? |
|
Definition
|
|
Term
| Most common drug used before dental procedures as prophylaxis |
|
Definition
|
|
Term
| Prophylaxis for penicillin allergic patient |
|
Definition
| Clindamycin, Azithromycin, Erythromycin NOT Ampicllin |
|
|
Term
| Which patients SHOULD you pre-medicate before dental procedures |
|
Definition
| History of Endocardidits, valve replacement, congenital heart defects |
|
|
Term
| Folic acid analog that inhibits dihydrofolate reductase |
|
Definition
|
|
Term
| Pyrimidine analog that inhibits thymidylate synthase |
|
Definition
|
|
Term
| Inhibitor of de novo purine synthesis |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Alkylating agents used to treat Non-Hodgkin lymphoma, breast and ovarian carcinoma. |
|
Definition
| Cyclophosphamide, ifosfamide |
|
|
Term
| Free radical generator and also intercalates DNA to from strand breaks ("A" in ABVD treatment for Hodgkins) |
|
Definition
| Doxorubicin (Adriamycin), daunorubicin |
|
|
Term
| Standard premedication guidelines for Amoxicillin |
|
Definition
| 2 grams orally one hour before |
|
|
Term
| Standard premedication guidelines for Clindamycin |
|
Definition
| 600 mg orally one hour before |
|
|
Term
| Standard premedication guidelines for Azithromycin |
|
Definition
| 500 mg orally one hour before |
|
|
Term
| Lidocaine, mechanisim of action |
|
Definition
| Binds internally to sodium channels blocking the production of an action potential |
|
|
Term
| Toxicity includes Cushing-like symptoms |
|
Definition
| Prednisone (Cushing Syndrome can also be Paraneoplastic from a ACTH secreting neoplasm like Oat Cell Lung Cancer) |
|
|
Term
| Increased risk of endometrial carcinoma |
|
Definition
| Tamoxifen (Estrogen Receptor Antagonist) |
|
|
Term
|
Definition
| 900ppm Molecular Weight Ratio: 1/2.2 = .09%F X 10 = .9 mg/mL X 1000 = 900ppm |
|
|
Term
|
Definition
|
|
Term
| Rate of elimination is constant - what order elimination? What happens to target plasma concentration? |
|
Definition
| Zero order elimination; Target plasma concentration decreases linearly with time |
|
|
Term
| Rate of elimination is proportional to drug concentration - what order elimination? Target plasma concentration? |
|
Definition
| First order elimination Cp decreases exponentially with time |
|
|
Term
| Give examples of drugs with zero order elimination |
|
Definition
| Ethanol Phenytoin Aspirin (at high or toxic concentration) |
|
|
Term
| What phase of metabolism associated with cytochrome P450 |
|
Definition
|
|
Term
| What phase of metabolism associated with conjugation |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| amount needed for a given EFFECT |
|
|
Term
| pre and postsynaptic nervous system neurotransmitters: Parasymp |
|
Definition
| Ach (nicotinic) Ach (muscarinic) |
|
|
Term
| pre and postsynaptic nervous system neurotransmitters: Somatic |
|
Definition
| only one ;ACh (nicotinic) |
|
|
Term
| pre and postsynaptic nervous system neurotransmitters: Sympathetic |
|
Definition
| Pre = ACh(nicotinic); Post: NorEpi (Cholenergic) or Ach(Muscarinic)-sweat glands, adrenal medulla |
|
|
Term
|
Definition
| ACh ligand gated Na+/K+ channels |
|
|
Term
|
Definition
| ACh G- protein coupled receptors that act through 2nd messengers |
|
|
Term
| Release of NE from a sympathetic nerve ending is modulated by;;with mech |
|
Definition
| by NE itself, acting on presynaptic α2 autoreceptors, and by ACh, ;;angiotensin II, and other substances. |
|
|
Term
| selectivity for Sympathomimetics;;Epinephrine |
|
Definition
| α1, α2, β1, β2, low doses selective for β1 |
|
|
Term
| selectivity for Sympathomimetics;;NE |
|
Definition
|
|
Term
| antidote for Carbon monoxide |
|
Definition
|
|
Term
|
Definition
| Vitamin K, fresh frozen;plasma |
|
|
Term
| Mouthrise with long acting anti-plaque effect |
|
Definition
|
|
Term
| Where does Chlorhexadine adhere |
|
Definition
| Acquired pellicle on the tooth structure. |
|
|
Term
|
Definition
|
|
Term
| What drugs cause Acute cholestatic hepatitis |
|
Definition
|
|
Term
| What drugs cause Pseudomembranous |
|
Definition
| Clindamycin Treatment: Metronidiazone or Oral Vancomycin |
|
|
Term
| What drugs cause Permanent staining of the developing teeth |
|
Definition
|
|
Term
| What drugs cause Osteonecrosis of the jaw |
|
Definition
|
|
Term
| What drugs cause Gingival hyperplasia |
|
Definition
|
|
Term
| What drugs cause Osteoporosis |
|
Definition
|
|
Term
| What drugs cause Fanconi’s syndrome |
|
Definition
|
|
Term
| What drugs cause Tardive dyskinesia |
|
Definition
|
|
Term
| What drugs cause Nephrotoxicity & ototoxicity |
|
Definition
| Aminoglycosides, loop diuretics, cisplatin |
|
|
Term
| Too much EtOH can cause what compound to build up? |
|
Definition
|
|
Term
| Drug name Ending / Category -cycline |
|
Definition
| Antibiotic, protein synthesis inhibitor |
|
|
Term
| Drug name Ending / Category Antibiotic, protein synthesis inhibitor |
|
Definition
|
|
Term
| Drug name Ending / Category -olol |
|
Definition
|
|
Term
| Drug name Ending / Category -oxin |
|
Definition
| Cardiac glycoside (inotropic agent) |
|
|
Term
| Drug name Ending / Category Pituitary hormone |
|
Definition
|
|
Term
| selectivity for Sympathomimetics - Phenylephrine |
|
Definition
|
|
Term
| selectivity for Sympathomimetics - Albuterol |
|
Definition
|
|
Term
| Mechanism/selectivity for Sympathomimetics - terbutaline |
|
Definition
|
|
Term
| effect on BP and HR of - Norepinephrine |
|
Definition
| (α > β), ↑ BP, ↓ HR (reflex bradycardia) |
|
|
Term
| effect on BP and HR of - Epinephrine |
|
Definition
| nonselective - NC BP( increases systolic, but decreases diastolic) |
|
|
Term
| effect on BP and HR of - Isoproterenol |
|
Definition
|
|
Term
| Applications of Sympathomimetics - Epinephrine |
|
Definition
| Anaphylaxis, glaucoma (open;angle), asthma, hypotension |
|
|
Term
| Applications of Sympathomimetics - NE |
|
Definition
| Hypotension (but ↓ renal ;perfusion) |
|
|
Term
| Applications of Sympathomimetics - Phenylephrine |
|
Definition
| Pupil dilator, vasoconstriction, nasal decongestion |
|
|
Term
| Applications of Sympathomimetics - Albuterol, terbutaline |
|
Definition
| Asthma B2 agonist dilates conducting zone |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| oral-facial movements due to DA receptor sensitization |
|
|
