Shared Flashcard Set

Details

NBCE Part 1
LaRose Kreb's
44
Health Care
Professional
08/23/2012

Additional Health Care Flashcards

 


 

Cards

Term
1.       3 names for the kreb’s cycle.
Definition
1) TCA CYCLE, 2) CITRIC ACID CYCLE, 3) METABOLIC HUB
Term
2.       The kreb’s ccle is located in the _____ and occurs under _____ conditions.
Definition
MITOCHONDRIAL MATRIX, AEROBIC
Term
3.       The substrate for kreb’s cycle is the breakdown of products of _____, _____ and _____.
Definition
CARBOHYDRATES, FATS AND PROTEIN
Term
4.       The fuel to drive the krebs cycle is _____.
Definition
ACETYL COA
Term
5.       The end product of carbohydrate breakdown is _____, which is turned into _____.
Definition
PYRUVATE, ACETYL COA
Term
6.       Each acetyl-CoA generated from pyruvate is used to produce these 4 things.
Definition
1) 3 NADH, 2) 1 FADH2, 3) 1 GTP, 4) 2 CO2
Term
7.       Both _____ and _____ deliver electrons to the electron transport chain to generate energy by the process of oxidative phosphorylation.
Definition
NADH AND FADH2
Term
8.       Prior to the krebs cycle itself, a very important preliminary reaction occurs in which the 2 pyruvate molecules from glycolysis are converted to _____ losing CO2.
Definition
NADH AND FADH2
Term
9.       The 2 acetyl groups are activated by attaching them to a carrier molecule known as _____, forming acetyl CoA.
Definition
COENZYME A
Term
10.   _____ is the enzyme complex that creates acetyl CoA in the mitochondria.
Definition
PYRUVATE DEHYDROGENASE
Term
11.   Next, the 2 carbon acetyl group from acetyl CoA is jointed to a 4-carbon compound to produce a _____ which is much easier to oxidize.
Definition
PYRUVATE DEHYDROGENASE
Term
12.   This 6-carbon compound goes through a series of reactions, several which are _____ reactions.
Definition
OXIDATION-REDUCTION REACTIONS
Term
13.   Two molecules of CO2 are lost from the 6-carbon compound, regenerating the 4-carbon compound. Thus all 6 carbons of the original glucose molecule are converted to CO2, which is a waste product of catabolism. The oxygen molecules of the glucose molecule ultimately end up as part of the CO2, and _____ is produced at this step.
Definition
NADH
Term
14.   In the 1st step of the kreb’s cycle, _____ is formed when oxaloacetate is combined with acetyl CoA.
Definition
CITRATE
Term
15.   _____ is the enzyme used to convert citrate to oxaloacetate.
Definition
CITRATE SYNTHASE
Term
16.   The next step of the kreb’s cycle converts citrate to _____.
Definition
ISOCITRATE
Term
17.   _____ is the enzyme that converts citrate to isocitrate.
Definition
ACONITASE
Term
18.   Isocitrate is then converted to _____.
Definition
ALPHA-KETOGLUTARATE
Term
19.   _____ is the enzyme that converts alpha-ketoglutarate to isocitrate.
Definition
ISOCITRATE DEHYDROGENASE
Term
20.   What is the rate limiting step of the kreb’s cycle?
Definition
THE CONVERSION OF ALPHA-KETOGLUTARATE TO ISOCITRATE
Term
21.   When alpha-ketoglutarate is formed, one _____ is produced while one _____ is released.
Definition
NADH, CO2
Term
22.   Alpha-ketoglutarate is then converted to _____ which is catalyzed by the enzyme _____.
Definition
SUCCINYL COA, ALPHA-KETOGLUTARATE DEHYDROGNASE
Term
23.   When succinyl CoA is formed, one _____ is produced and one _____ is released.
Definition
NADH, CO2
Term
24.   In the 5th step of the krebs cycle, _____ is produced from succinyl CoA, which is catalyzed by the enzyme _____.
Definition
SUCCINATE; SUCCINATE THIOKINASE
Term
25.   When succinate is formed, one _____ is produced.
Definition
GTP
Term
26.   Succinate is then converted to _____ which is catalyzed by the enzyme _____.
Definition
FUMARATE; SUCCINATE DEHYDROGENASE
Term
27.   _____ is the only TCA cycle enzyme that is bound to the mitochondrial membrane instead of being soluble in the mitochondrial matrix.
Definition
SUCCINATE DEHYDROGENASE
Term
28.   Succinate dehydrogenase is the only TVA cycle enzyme that directly uses _____.
Definition
FAD
Term
29.   When succinate is converted to fumarate one _____ is produced.
Definition
FADH2
Term
30.   Fumarate is then converted to_____ which is catalyzed by the enzyme _____.
Definition
MALATE; FUMARASE
Term
31.   In the last step of the krebs cycle, malate is converted to _____ which is catalyzed by the enzyme _____.
Definition
OXALOACETATE; MALATE DEHYDROGENASE
Term
32.   The formation of oxaloacetate produces one _____.
Definition
NADH
Term
33.   Oxaloacetate is then added to_____ to re-enter the cycle.
Definition
ACETYL COA
Term
34.   The 3 NADH, 1 FADH2, 1GTP, and 2 CO2 produced from the krebs cycle enter the _____ through the process of _____.
Definition
ELECTRON TRANSPORT CHAIN, OXIDATIVE PHOSPHORYLATION
Term
35.   Since NADH and FADH2 cannot physically cross the mitochondrial membrane, the electrons must be shuttled into the mitochondria by organ specific shuttles, namely via the _____ and _____ shuttles.
Definition
GLYCEROL-3-PHOSPHAT AND MALATE ASPARTATE SHUTTLES
Term
36.   Where is the electron transport chain located?
Definition
IN THE MITOCHONDRIAL MEMBRANE
Term
37.   After entering the electron transport chain, each NADH produces _____ ATP’s.
Definition
3 ATP’S
Term
38.   After entering the electron transport chain, each FADH produces _____ ATP’s.
Definition
2 ATP’s
Term
39.   Each pyruvate molecule produced eventually yields _____ ATP’s.
Definition
12 ATP’S
Term
40.   2 molecules of pyruvate from 1 glucose molecule will yield _____ ATP’s from the kreb’s cycle.
Definition
24 ATP’s
Term
41.   How many total ATP’s are produced by the Kreb’s cycle?
Definition
NONE, ATP IS ONLY RELEASED WHEN NADH AND FADH2 ENTERS THE ELECTRON TRANSPORT CHAIN IN THE MITOCHONDRION
Term
42.   Each molecule of glucose going through glycolysis and the krebs cycle will yield a total of _____ATP’s.
Definition
38 ATP’S
Term
43.   4 points of the krebs cycle where proteins can enter.
Definition
(SOFA) 1) SUCCINYL COA, 2) OXALOACETATE, 3) FUMARATE, 4) ALPHA-KETOGLUTARATE
Term
44.   2 points where fats can enter the kreb’s cycle.
Definition
1) ALPHA KETOGLUTARATE, 2) SUCCINYL COA
Supporting users have an ad free experience!