Term
| Time > MIC |Time dependent antibiotics are? |
|
Definition
|
|
Term
| Time > MIC - Time dependent antibiotics goals? |
|
Definition
| Drug level > MIC for entire dosing interval via short dosing interval |
|
|
Term
| ABs that TX: Community Associated MRSA SSTI |
|
Definition
SMX/TMP (Bactrim DS)
Doxycycline or Minocycline
Clindamycin
Linezolid |
|
|
Term
| ABs that TX: Severe SSTI requiring hospitilaztion / IV therapy |
|
Definition
***Must cover MRSA and strep ***
Vancomycin
Linezolid or tedizolid
Daptomycin
Ceftaroline
Telavancin
Oritavancin
Dalbavancin
Quinupristin/Dalfopristin
Tigecycline |
|
|
Term
| ABs that TX: Noscomial MRSA |
|
Definition
Vancomycin
Linezolid
Televancin
Daptomycin (not pneumonia)
Rifampin (never alone) |
|
|
Term
| ABs that TX: VRE (e. faecalis) |
|
Definition
Pen G or ampicillin
Linezolid
Daptomycin
Tigecycline
If cytitis only: nitrofurantoin, fosfomycin, doxycycline |
|
|
Term
| ABs that TX: VRE (e. faecium) |
|
Definition
Daptomycin
Linezolid
Quinupristin/Dalfopristin
Tigecycline
If cytitis only: nitrofurantoin, fosfomycin, doxycycline |
|
|
Term
| ABs that TX: pseudomonas aeruginosa |
|
Definition
Piperacillin/tazobactam
Cefepime
Ceftazidine
Ceftazidine/Avibactam
Ceftolozane/Tazobactam
Carbapenems (NOT ertapenem)
Ciprofloxacin, Levofloxacin
Aztreonam
Aminogylcosides
Colistimethate, polymixin B |
|
|
Term
| ABs that TX: acinetobacter baumannii |
|
Definition
carbapenems (except ertapenem)
ampicillin/sulbactam
minocycline
tigecycline
quinolones
SMX/TMP
Colistmethate, polymixin B |
|
|
Term
|
Definition
Carbapenems
ceftolozane/tazobactam
cefepime (high dose)
Aminogylcosides
Cystitis only: fosfomycin |
|
|
Term
| ABs that TX: carbapenem-resistant G- Rods (CRE) |
|
Definition
ceftazidime/avibactam
colistimethate, polymixin B |
|
|
Term
| ABs that TX: Bacteroides fragilis |
|
Definition
metronidazole
Beta-lactam/beta-lactamse inhibitor
cefotetan, cefoxitin
carbapenems
tigecycline |
|
|
Term
| ABs that TX: C. difficile |
|
Definition
Vancomycin (1rst!)
Fidaxomicin (2nd!)
Metronidazole |
|
|
Term
| ABs that TX: Atypical organisms |
|
Definition
Azithromycin, clarithromycin
Doxycycline, minocycline
Quinolones |
|
|
Term
|
Definition
Amoxicillin (beta-lactamase negative)
Beta-lactam/beta-lactamase inhibitor
Cephlasporin (NOT Gen 1)
Carbapenems
SMX/TMP
Aminoglycosides
Quniolones |
|
|
Term
| Brand/Generic: Penicillin |
|
Definition
|
|
Term
| Brand/Generic: Penicillin G Benzathine |
|
Definition
|
|
Term
| Brand/Generic: Amoxicillin |
|
Definition
|
|
Term
| Brand/Generic: Amoxicillin + clavulanate |
|
Definition
|
|
Term
| Brand/Generic: Ampicillin + sulbactam |
|
Definition
|
|
Term
| Brand/Generic: Piperacillin + tazobactam |
|
Definition
|
|
Term
| Coverage: Natural Penicillins (penicillin, benzathine) |
|
Definition
Streptococci (incr. resistances)
Enterococci
G+ anaerobes (mouth flora) |
|
|
Term
| Coverage: Aminopenicillins (amoxicillin) |
|
Definition
Natural penicillin coverage + HNPEK
Augmentin - clauvunate adds coverage for: MSSA, G- anaerobes (B. fragilis) |
|
|
Term
| Coverage: Extended spectrum Penicillins (Zosyn) |
|
Definition
| Augmentin coverage + CAPES + pseudomonas |
|
|
Term
| Coverage: Antistaphyloccals (nafacillin, oxacillin, dicloxacillin) |
|
Definition
|
|
Term
| __________________ is first line treatment for strep throat and mild nonpurulent skin infections |
|
Definition
|
|
Term
| __________________ is first line treatment for otitis media |
|
Definition
|
|
Term
| __________________ is drug of choice for infective endocarditis prophylaxis in dental procedures? |
|
Definition
|
|
Term
| __________________ is drug of choice for syphilis |
|
Definition
Penicillin G benzathine (Bicillin-LA)
2.4M U IM x 1 dose |
|
|
Term
| __________________ is only penicillin with psuedomanonas coverage |
|
Definition
| Piperacillin/tazobactam (Zosyn) |
|
|
Term
| Dicloxacillin + naficillin v. warfarin? |
|
Definition
| Decrease INR through increased metabolism of warfarin |
|
|
Term
| Penicillins v. methotrexate? |
|
Definition
|
|
Term
| Tetracyclines and penicillins? |
|
Definition
| Tetracyclines decrease the effectiveness of penicillins by slowling bacterial growth. |
|
|
Term
| Coverage: First generation cephlasporin |
|
Definition
| (cephalexin, cefazolin) MSSA, PEK |
|
|
Term
| Coverage: Second generation cephlasporin |
|
Definition
Grp #1 (cefuroxime) - s. penumo, HNPEK
Grp #2 (cefotetan) - adds anaerobe coverage (B. fragilis) |
|
|
Term
| Coverage: Third generation cephlasporin |
|
Definition
Grp #1 (cefdinir, ceftriaxone, cefotaxime) - resistant strep, enhance G- coverage
Grp #2 (ceftazidime) - NO G+ activity, psuedomonas |
|
|
Term
| Coverage: Fourth generation cephlasporin |
|
Definition
| (cefepime) - resistant strep, pseudomonas |
|
|
Term
|
Definition
| Outpatient: Skin infections (MSSA), strep throat |
|
|
Term
|
Definition
| Outpatient: Otitis media, CAP, sinus infection |
|
|
Term
|
Definition
| Outpatient: CAP, sinus infection |
|
|
Term
|
Definition
| Inpatient: surgical prophylaxis |
|
|
Term
| Common uses: cefotetan, cefoxitin |
|
Definition
| Inpatient: Anaerobe (B. fragilis), surgical proph, |
|
|
Term
| Causes disulfiram-like reactions with alcohol? |
|
Definition
|
|
Term
| Common uses: ceftriaxone, cefotaxime |
|
Definition
| Inpatient: CAP, meningitis, spontaneous bacterial peritonitis, pylenephritis |
|
|
Term
| Common uses: ceftazidime, cefepime |
|
Definition
|
|
Term
Common uses:
ceftolozane/tazobactam
ceftazidime/avibactam |
|
Definition
| Inpatient: MDR G- organisms including pseudomonas |
|
|
Term
|
Definition
| Inpatient: the only beta-lactam active against MRSA |
|
|
Term
|
Definition
|
|
Term
| Brand/generic: cephalexin |
|
Definition
|
|
Term
| Brand/generic: cefuroxime |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Brand/generic: ceftriaxone |
|
Definition
|
|
Term
| Brand/generic: cefotaxime |
|
Definition
|
|
Term
| Brand/generic: ceftazidime |
|
Definition
|
|
Term
| Brand/generic: ceftazidime + avibactam |
|
Definition
|
|
Term
| Brand/generic: ceftolozane + tazobactam |
|
Definition
|
|
Term
|
Definition
| ceftriaxone; due to biliary sludging |
|
|
Term
|
Definition
|
|
Term
| Brand/generic: ceftaroline fosamil |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Carbapenem exhibit ______ - dependent antibacterialactivity |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Administration: carbapenems |
|
Definition
|
|
Term
| Ertapenem must be diluted in ___________ |
|
Definition
|
|
Term
| Unlike other carbapenems Ertapenem does not cover |
|
Definition
| pseudomonas, acinetobacter, enterococcus |
|
|
Term
| As a class carbapenems do not cover: |
|
Definition
| Atypicals, VRE, MRSA, C. diff, Stenotrophomonas |
|
|
Term
|
Definition
Polymicrobial infections (diabetic foot inf.)
Emperic therapy of resistant organizations
Resistant pseudomonas or acinetobacter |
|
|
Term
| Monobactam drug list- brand/generic: |
|
Definition
|
|
Term
|
Definition
*** similar to ceftazidime ***
NO G+ coverage,
covers many G-,
pseudomonas |
|
|
Term
| Aztreonam is commonly used when __________________ |
|
Definition
| a patient has a beta lactam allergy. |
|
|
Term
| Beta lactam spectrum: MRSA coverage (1 drug) |
|
Definition
|
|
Term
| Beta lactam spectrum: NO MSSA coverage (4 drugs) |
|
Definition
| penicillin, amoxicillin, ceftazidime, aztreonam |
|
|
Term
| Beta lactam spectrum: enteroccous coverage (4 drugs) |
|
Definition
| penicillin, amoxicillin, piperacillin/tazobactam, carbapenem |
|
|
Term
| Beta lactam spectrum: pseudomonas (5 drugs) |
|
Definition
ceftazidime, aztreonam, cefepime, carbapenem,
ceftolozane/tazobactam |
|
|
Term
| Beta lactam spectrum: atypicals |
|
Definition
|
|
