Term
| Hep C (HCV) is a ____________ virus |
|
Definition
|
|
Term
|
Definition
Drug users
HIV
Blood transfusions < 1992
Clotting factors < 1987
Hemodialysis pts
Healthcare workers via mucosal / needle exposure
Non sterile tattoos
Born 1945 - 1965
Children born to mothers w/ HCV |
|
|
Term
|
Definition
| Test for antibodies (anti-HCV) |
|
|
Term
| HCV is detectable w/in __ - ___ weeks of exposure |
|
Definition
|
|
Term
| How many HCV genotypes? Which is most common in U.S. |
|
Definition
|
|
Term
| Tx: genotype 1a/1b w/o cirrhosis |
|
Definition
daclatasvir + sofosbuvir X 12wk
Ledipasvir/sofosbuvir X 12wk
Simeprevir + sofosbuvir X 12wk
Ombitasvir/paritaprevir/ritonavir + dasabuvir + RBV X 12wk (no RBV for genotype 1b) |
|
|
Term
| Tx: genotype 1a/1b w/ cirrhosis |
|
Definition
Same as w/o but duration for most therapies incr to 24wks
*Ledipasvir/sofosbuvir remains as 12wk duration
** Option to add RBV to daclatasvir + sofosbuvir regimen |
|
|
Term
| Pearls: peginterferon alfa-2a + alpha-2b |
|
Definition
MOA: induces innate antiviral immune response
Brand: Pegasys (a2a), Pegintron (a2b)
Dosing: SQ INJ Qwk
S/E: Flu-like, psyc, blood, thyroid, liver |
|
|
Term
|
Definition
MOA: inhibits replication of DNA (HBV) and RNA (HCV)
Brand: Copegus (w/ a2a), Rebetol (w/ a2b)
Dosing: PO
* Req forms of birth control; cannot get preg for 6mo after tx ends
**Never as monotherapy |
|
|
Term
|
Definition
MOA: inhibits HCV replication by blocking NS3/4A protease inhibitor
Brand: Olysio
Dosing: PO
S/E: photosensitivity
*Do NOT use in pts w/ NS3 Q80K polymorphism
**Sulfa drug
***not for monotherapy |
|
|
Term
|
Definition
MOA:blocks HCV replication by inhibiting NS5A protein
Brand: Daklinza
*3A4 substrate; P-gp inhibitor
**Must be used with sofosbuvir |
|
|
Term
|
Definition
MOA: inhibits HCV replication by blocking NS5B RNA-dependent RNA polymerase
Brand: Sovaldi
*P-gp substrate
**Avoid in pts also taking amiodorone (incr risk bradicardia)
**Must use with RBV or PEG + RBV |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Ombitasvir/paritaprevir/ritonavir (must take w/ RBV) |
|
|
Term
|
Definition
| Ombitasvir/paritaprevir/ritonavir + dasabuvir (two tablets in pak) |
|
|
