Term
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Definition
| Bronchoconstriction of smooth muscle caused by external stimuli (buzz word: "reactive") leading to epithial remodeling and loss of cillia in lungs. |
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Term
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Definition
1. Check skin/airway response to allergen
2. Spirometry - FEV1/FVC ration < 80% |
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Term
| Asthma: Steps of mgmt (ABCDE) |
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Definition
1. Assess/measure
2. Body (control comorbidities)
3. Cousel/education
4. Drugs
5. Environment (control environment) |
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Term
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Definition
Green FEV1 > 80%
Yellow FEV1 50-80%
Red FEV1 <50% |
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Term
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Definition
1. Identify triggers
2. Manage GERD
3. Avoid aspirin
4. Smoking cessation
5. Clean house
6. Keep track of: SABA use and Nighttime awakenings |
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Term
| Treat mild/intermittenet/exercise induced asthma (Step 1) |
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Definition
SABA
SABA Examples:
Albuterol (Ventolin/Proair)
Levoalbuterol (Xopenex) |
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Term
| Treat mild presistant asthma (Step 2) |
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Definition
SABA + ICS ***Optional Add Singulair****
ICS Examples:
Fluticasone (Flovent/Arnuity/Ellipta)
Budesonide (Pulmicort/Respules)
Beclomethasone (QVAR)
Mometasone (Asmanex) |
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Term
| Treat moderate presistent asthma (Step 3) |
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Definition
SABA + ICS + LABA
LABA Examples:
Salmeterol (Serevent)
Formeterol (Foradil/Perfomist)
Olodaterol (Striverdi Respimat) |
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Term
| Treat severe presistent asthma (Step 4) |
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Definition
| SABA + ICS (Medium dose) + LABA |
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Term
| Treat severe presistent asthma w/ poor ICS response (Step 5/6) |
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Definition
| SABA + ICS (High dose) + LABA + Oral Steroid (Step 6) |
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Term
| All asthma pts must be prescribed ___________ |
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Definition
SABA
SABA Examples:
Albuterol (Ventolin/Proair)
Levoalbuterol (Xopenex) |
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Term
| SABAs avaliable for nebulizer |
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Definition
Albuterol (Ventolin/Proair)
Levoalbuterol (Xopenex) |
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Term
|
Definition
| fluticasone >>>>> budesonide |
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Term
|
Definition
|
|
Term
|
Definition
|
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Term
|
Definition
Fluticasone (Flovent/Arnuity/Ellipta)
Budesonide (Pulmicort/Respules)
Beclomethasone (QVAR)
Mometasone (Asmanex) |
|
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Term
| Can LABA be used as monotherapy? |
|
Definition
| NOOOOOOOOOOO! (increased death) |
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Term
|
Definition
Salmeterol (Serevent)
Formeterol (Foradil/Perfomist)
Olodaterol (Striverdi Respimat) |
|
|
Term
| Mast stabilizer drugs (2 drugs) |
|
Definition
Chromolyn (Gastrocom)
Omalizumab (Xolair) |
|
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Term
| Mast stabilizaer avaliable as nebulizer |
|
Definition
|
|
Term
| Exciting facts about omalizumab (Xolair) |
|
Definition
Reserve for pt w/ severe asthma/allergy
SQ injection
Anaphylaxis risk |
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Term
| Luekotriene modifier drugs (3 drugs) |
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Definition
Montelukast (Singulair)
Zafilukast (Accolate)
Zileuton (Zyflo) |
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Term
| Luekotriene modifier LTD4/E4 MOA |
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Definition
| Luekotriene RECEPTOR antagonist LTD4 and/or LTE4 (montelukast is LTD4 only) |
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Term
| Luekotriene modifier: why is montelukast more commonly used? |
|
Definition
Approval for 1 y.o.
Does not cause liver problems |
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Term
| ____________________ can be used instead of an ICS in mild/moderate asthma? |
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Definition
|
|
Term
| Luekotriene modifier: 5-lipoxygenase inhibitor drug list (1 drug) |
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Definition
|
|
Term
| Luekotriene modifier: 5-lipoxygenase inhibitor MOA |
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Definition
| 5-lipoxygenase inhibitors (Zyflo) inhibits luekotriene formation |
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Term
| Exciting facts about zileuton (Zyflo) |
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Definition
|
|
Term
|
Definition
|
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Term
| Theophylline goal range + signs of tox |
|
Definition
Goal: 10-20mcg/mL
Toxic signs = vommitting |
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Term
| ________________ it the IV version of theophylline |
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Definition
|
|
Term
| Aminophyilline is not comaptible with ________________ |
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Definition
|
|
Term
| Define well-controlled asthma |
|
Definition
No limitations to normal activity
≤ 2d/wk SABA use
≤ 2d/wk nighttime awakenings
≤ 1/yr |
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Term
|
Definition
| Forced Vital Capacity (meas. of big exhale) |
|
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Term
|
Definition
| Forced Expiratory Volume (amount of air that can be forecably exhaled in 1 second) |
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|
Term
|
Definition
bondesonide/formoterol (Symbicort)
fluticasone/salmeterol (Advair)
mometasone/formoterol (Dulera) |
|
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Term
|
Definition
| (due to 1A2 inhibition): cimetidine, ciprofloxacin, fluvoxamine, propanolol, zafirlukast, zileuton |
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