Term
|
Definition
| 617 valine to phenyalanine, spontaneous firing of EPO receptor without approrpriate signal |
|
|
Term
| in CML is the germline affected? |
|
Definition
| no acquired not congential. only in hematopoetic cell line. |
|
|
Term
| what cell line is the bcr/able mutation in? |
|
Definition
|
|
Term
| T/F: in essential thrombocytopenia you can have hemmorhage or thrombosis? |
|
Definition
| T. platelets can be inactive or too active. |
|
|
Term
| T/F you would expect to see left shift in immature leukocytes in ET? |
|
Definition
|
|
Term
| paroxysomal noctural hemogloinuria is a myelodypslastic syndrome? |
|
Definition
| F. neither myelodysplastic or myeloproliferative. |
|
|
Term
| myeloproliferative disorder? common findings? |
|
Definition
| pancytopenia, hypercellular bone marrow, common in >60, usually die from infection or it becomes AL |
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|
Term
| what are the major requirements of pvera |
|
Definition
| splenomegaly, normal o2 sat >92% and increased RBC |
|
|
Term
| what are the minor requirement of pvera diagnosis and what do you need to diagnose pvera |
|
Definition
| -thrombocytosis, leukocytosis, LAP no fever or infection, serum b12, must have all three major criter or increase RBC mass an dnormal o2 sat + 2 minor |
|
|
Term
| T/F paraoxysomal nocturnal HBG is can be cause by aplastic anemia? |
|
Definition
| T and false, PNH can cause aplastic, or aplastic can cause PNH |
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