Term
Mycoplasma
Pathogenic strains |
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Definition
* Mycoplamsa pneumoniae
* Mycoplasma hominis
* Mycoplasma urelyticum |
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Term
Mycoplasma Characteristics |
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Definition
Smallest, simplest, self replicate
No rigid cell wall, have a cholesterol cell membrane, can be many shapes
Can pass through some filters
Complex media needed, fastidious
Facultative anaerobes (except pneumoniae, aerobe)
Fried egg colonies on agar or broth, slow growth!
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Term
M. pneumoniae Pathogenesis |
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Definition
* Only human pathogens
*inhale aerosol particles, enter with lancelet ends
* Do not invade mucosa cilia movement inhibited
* Extracellular pathogen |
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Term
Mycoplasma pneumoniae Virulence Factors |
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Definition
* Cytoadhesins allows binding to sialic acid in respiratory epithelial cells>inflammation, necrosis
* H2O2 and superoxide ion produces w metabolism, can also inhibit host catalase
* Activate macrophage and stimulate cytokine production and lymphocyte activation
*cold (cross) aglutiniation with RBC, brain, heart, liver
* Outbreaks with people in close contact |
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Term
M. pneumoniae clinical symptoms |
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Definition
*Atypical pneumonia, fever headache malaise>non productive cough> respiratory symptoms (x ray+ before symptoms!)
* 70-80% infections are tracheobronchitis
*rarely fatal |
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Term
M. pneumoniae Lab Diagnosis
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Definition
* Microscopy- not super useful do to lack of wall
* Culture-essential for definitive, sputum culture
* Serology (complement (4-6 wks after infection), cold agglut, ELISA) |
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Term
M. pneumoniae Treatment and Prevention |
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Definition
* Tetracycline in adults erythromycin
* Hard to prevent du to long duration. No vaccines
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