Term
|
Definition
opportunistic pathogen
commonly in mucous membranes
when they become pathogenic they locally penetrate membranes causing irritation and shedding of tissues |
|
|
Term
|
Definition
most common for causing disease in immunocompromised
can invade pulmonary tissues and blood vessels
can get into body via inhaled spores |
|
|
Term
| types of aspergillus disease |
|
Definition
allergic bronchopulmonary aspergillosis
chronic necrotising aspergillosis pneumonia
invasive aspergillosis
pulmonary aspergilloma |
|
|
Term
|
Definition
ergosterol inhibitors
echinocandins
others |
|
|
Term
|
Definition
polyenes - make cell walls less fluid and more leaky
azoles
bind to ergosterol, destabilising fungal cell wall |
|
|
Term
|
Definition
| inhibit 1-3 beta glucan synthase stopping cell wall synthesis |
|
|
Term
|
Definition
chitin biosynthesis inhibitors - weakens cell wall
dan synthesis inhibitors - mimicked nucleotides stop replication - flu cytosine instead of cytosine
mitosis inhibitors - disrupts microtubule aggregation so cell can't divide properly |
|
|
Term
|
Definition
parasites grow and multiply fast in liver then RBC
fever chills sweats headaches nausea body aches
lethal if untreated |
|
|
Term
|
Definition
obligate intracellular parasite
causes toxoplasmosis
can effect any warm blooded individual
can only grow in cats
can be asymptomatic
eye pain, photophobia, blurred vision |
|
|
Term
|
Definition
vector borne disease
transmitted via sand flies
many causation species
skin irritation, fever, weight loss, hepatosplenamegaly |
|
|
Term
|
Definition
tsetse fly injects trypanosomes during blood meal
enter lymphatics and blood stream
fever, headaches, muscle and joint aches, malaise
after1-2 years
-personality change
-daytime sleepiness
-progressive confusion
-partial paralysis |
|
|
Term
|
Definition
| drug resistance and toxicity is a major problem |
|
|
Term
|
Definition
against malaria
reacts with haem
generates free radicals that kill potential proteins |
|
|
Term
|
Definition
against leishmania
interacts with lipids
inhibits cytochromic oxidase
can't metabolise
apoptosis |
|
|
Term
|
Definition
against sleeping sickness
irreversibly binds to ODC
can't metabolise
parasite dies
expensive
not effective on all species |
|
|
