Term
| am i susceptible to mycobacterium tuberculosis? |
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Definition
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Term
| what does M. tuberculosis do to the lungs? |
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Definition
| induces a vigorous cell-mediated immune response, causing severe tissue damage |
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Term
| can you find viable M. tuberculosis in the lesions caused by TB? |
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Definition
| yes, they remain indefinitely |
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Term
| what kind of stain is used to diagnose TB? |
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Definition
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Term
| what is a primary infection? |
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Definition
| a single lesion in the lungs |
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Term
| what does post-primary (AKA secondary) TB indicate? |
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Definition
| TB reactivated and started miliary (multiple) lesions |
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Term
| what cells does Mycobacterium tuberculosis infect? |
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Definition
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Term
| is M. tuberculosis motile? how does it infect other hosts? |
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Definition
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Term
| T/F: it is a facultative intracellular pathogen |
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Definition
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Term
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Definition
| False! its an obligate aerobe. there is a reason why it grows in the lungs most often! |
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Term
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Definition
| no. it WANTS to engulfed by macrophages |
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Term
| is the cell wall immunogenic? |
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Definition
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Term
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Definition
| tuberculin (purified protein derivative) |
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Term
| what happens to the bug after its phagocytosed by macrophages? |
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Definition
| it grows in the vacuole and inhibits fusion with lysosomes |
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Term
| what happens if a tubercule (cavitation) ruptures? |
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Definition
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Term
| what does it mean to have a PPD+ skin test? |
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Definition
| you can have the bug, but you aren't necessarily symptomatic. |
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Term
| can you count on a negative PPD skin test from a AIDs patient? |
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Definition
| no, it requires a normal immune response. |
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Term
| can other strains of mycobacterium tuberculosis infect AIDS patients? |
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Definition
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Term
| what are the reasons treatments for TB take a long time? |
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Definition
| 1) thick cell wall, 2) grows intracellularly, 3) may reside in tubercles, 4) grows slowly |
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