Term
| what is myasthenia gravis? |
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Definition
| it is an autoimmunie disease |
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Term
| what is the patho of myasthenia gravis? |
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Definition
ack of nerve impulses and muscle responses at myoneural junction
Lack of acetylcholine reaching cholinergic receptors |
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Term
| what are the characteristics of myasthenia gravis? |
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Definition
Muscular weakness and fatigue
Respiratory muscle paralysis, ptosis, difficulty chewing and swallowing |
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Term
| what type of drugs are used? |
|
Definition
cholinesterase inhibitors such as neostigmine (prostigmin): short acting, Edrophonium (Tensilon): ultrashort-acting for diagnosing
Pyridostigmine (Mestinon): intermediate acting |
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Term
| what is the action of MG? |
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Definition
| Transmission of neuromuscular impulses by preventing destruction of Ach |
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Term
|
Definition
Autoimmune disorder
Attacks myelin sheath of nerve fibers
Cause lesions or plaques |
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Term
| what are the characteristics of MS? |
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Definition
Remissions and exacerbations
Weakness or spasticity in extremities
Diplopia |
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Term
| what is the best way to identify MS? |
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Definition
| an MRI or a protiens in the spinal tap |
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Term
| what are the characteristics of overdoisng and underdosing? |
|
Definition
Similar symptoms
Muscle weakness, dyspnea
Dysphagia, abdominal cramping
Drooling, increases tearing, sweating
Bradycardia |
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Term
| what is myasthenia crisis? |
|
Definition
|
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Term
| what is cholinergic crisis? |
|
Definition
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Term
| what are some of the drugs for MS? |
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Definition
Glucocorticoid (Prednisone)
Biologic response modifiers (interferon-beta)
Immunosuppressants:
Azathioprine (Imuran)
Cyclophosphamide (Cytoxan) |
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Term
| what are some of the muscle relaxants used for MS? |
|
Definition
Carisoprodol (Soma)
Cyclobenzaprine (Flexeril)
Methocarbamol (Robaxin) |
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Term
| what are some of the uses of skeletal muscle relaxants? |
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Definition
Suppress muscular hyperactivity
Relax muscles in spasm |
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Term
| what does carisoprodol (soprodol) do? |
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Definition
| it is a skeletal muscle relaxant to treat spasticity |
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Term
| what are the carisoprodol (soprodol) side effects? |
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Definition
Diplopia, diplopia
GI distress, weakness, insomnia
Tachycardia, hypotension |
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Term
| what are some of the side effects of the skeletal muscle relaxants? |
|
Definition
Drowsiness, sedation
Dizziness
Headaches
GI distress
Drug dependence |
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Term
| what is a myasthenia crisis? |
|
Definition
| severe muscle weakness that is improved with edrophonium |
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Term
| what is the colinergic crisis? |
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Definition
| severe muscle weakness that is helped by cholinesterase inhibitors |
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Term
| what are the side effects of cholinesterase inhibitors? |
|
Definition
Pupil constriction
GI distress, abdominal cramps
Excess saliva, sweating
Headache, dizziness, seizures
Hypotension, bradycardia, dysrhythmias
Bronchospasm, respiratory depression |
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