Term
phosphatidylinositol -> arachidonic acid
1) enzyme
2) inhibited by |
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Definition
1) phospholipase A2
2) corticosteroids |
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Term
arachidonic acid -> hydroperoxides -> leukotrienes
1) enzyme
2) inhibited by
3) receptor inhibitors |
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Definition
1) lipoxygenase
2) zileuton
3) zafirlukast, montelukast |
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Term
AA -> endoperoxidases
1) enzyme
2) inhibited by |
|
Definition
1) COX
2) NSAIDS, acetaminophen, COX-2 inhibitors, ASA |
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Term
|
Definition
|
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Term
|
Definition
| leukotrienes, thromboxane |
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Term
| decreased platelet aggregation |
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Definition
|
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Term
|
Definition
| prostacyclin, prostaglandin |
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Term
|
Definition
| prostacyclin, prostacyclin |
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Term
|
Definition
|
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
|
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Term
|
Definition
| irreversitly inhibits COX by acetylation which dec synthesis of TXA2 and PG |
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Term
|
Definition
low dose = platelet aggregation dec
intermediate = antipyretic and analgesic
- high dose = anti-inflammatory |
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Term
|
Definition
| gastric ulcer, hyperventilation, tinnitus, acute renal failure, interstitial nephritis and upper GI bleeding; Reye's |
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Term
|
Definition
- ibuprofen, naproxen, indomethacin, ketorlac
- reversibly inhibit COX, block PG synthesis |
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Term
|
Definition
- antipyretic, analgesic, anti-inflammatory; close PDA = indo
- renal damage, fluid retention, aplastic anemia, GI distress, ulcers |
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Term
COX2 inhibitors
- use
- toxicity |
|
Definition
- RA and OA; gastritis or ulcers
- inc risk of thrombosis, sulfa allergy, less toxicity to GI mucosa |
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Term
|
Definition
- reversibly inhibits COX most lyin CNS, inactivated peripherally
- antipyretic, analgesic; NO ANTI-INFLAMM |
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Term
acetaminophen
- toxicity
- OD tx |
|
Definition
- hepatic necrosis
- N-acetylcystein |
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Term
bisphosphonates
- names
- MOA |
|
Definition
- etidronate, pamidronate, alendronate, risendronate, zolendronate
- inhibits osteoclatic activity -> reduce formation and serration of hydroxyapatite |
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|
Term
bisphosphonates
- use
- toxicity |
|
Definition
- malignancy ass hypercalcemia, Paget's, postmenopausal osteoporosis
- corrosive esophagitis, nausea, diarrhea, osteonecrosis of jaw |
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Term
|
Definition
|
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Term
|
Definition
| probenecid, allopurinol, febuxostat |
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Term
|
Definition
| inhibits reabsorption of uric acid in PCT; inhibits secretion of penicillin |
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Term
|
Definition
| inhibits xanthing oxidase |
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|
Term
| also used in lymphoma and leukemia to prevent tumor lysis |
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Definition
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|
Term
| increases concentrations of azathioprine and 6-MP |
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Definition
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Term
|
Definition
| inhibits xanthine oxidase |
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|
Term
|
Definition
| stabilizes tubulin to inhibit polymerization, imairing leukocyte chemotaxis and degranulation; GI SE if given orally |
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