Term
|
Definition
| An involuntary contraction |
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Term
|
Definition
| Lactic acid buildup during exercise |
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Term
|
Definition
|
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Term
|
Definition
|
|
Term
| What is the cause of tetany? |
|
Definition
|
|
Term
| What is the consequence of hypocalcemia? |
|
Definition
| Increased sodium permeability - therefore random depolarizaitons and contractions |
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Term
| Name 3 things that could lead to hypocalcemia? |
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Definition
|
|
Term
| What is trousseau's sign? |
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Definition
| "Claw hand" due to hypocalcemia |
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Term
| What is muscular dystrophy? |
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Definition
|
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Term
| What are the two causes of muscular dystrophy? |
|
Definition
- Genetic problem
- Ion permeability abnormalities |
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Term
| What occurs with the genetic problem? |
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Definition
|
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Term
| What is the role of dystrophin normally? How could problems with it lead to dystrophy? |
|
Definition
- Links actin to myosin surface; control ion permeability
- Problems = compromised linkage = compromised contraction |
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Term
| Why can ion permeability problems occur? |
|
Definition
| Because dystrophin also regulations ion permeability |
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Term
| (T/F) Duchenne's is the most common type of musc dyst |
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Definition
|
|
Term
| How is it inherited? What does this mean? |
|
Definition
| X-linked; males are more likely to get it |
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Term
| Describe the course of Duchenne's |
|
Definition
- Early onset
- Rapid progression |
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|
Term
| What is seen in myotonic dystrophy? What might cause this? |
|
Definition
| - Delayed relaxation; ion permeability issues |
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Term
|
Definition
|
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Term
| (T/F) myotonic dystrophy exhibits fast progression |
|
Definition
|
|
Term
| List other characteristics of muscular dystrophy common to both types |
|
Definition
o ↑ creatine kinase
o muscle replaced by fat & connective tissue
o cardiomyopathy
o Gower’s maneuver
o vertebral deformities |
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|
Term
| When does cardiomyopathy occur? |
|
Definition
| When muscular dystrophy occurs in the heart |
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|
Term
| What is grower's manouver? |
|
Definition
| "climbing" legs to stand up, because of muscular weakness |
|
|
Term
| Why can vertebral problems occur? |
|
Definition
| Because muscles help keep the spine aligned, so weakened muscles can cause misalignment of the spine |
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|
Term
| What is characteristic of fibroomyalgia syndrome? |
|
Definition
| Pain, stiffness in muscles and tendons WITH NO obvious inflammation |
|
|
Term
| (T/F) Joint stiffness is seen as well |
|
Definition
|
|
Term
| How many trigger points are there for FS? Do they all need to be triggered? |
|
Definition
|
|
Term
| (T/F) SF may accompany IBS |
|
Definition
|
|
Term
| What sex is more susceptible? |
|
Definition
|
|
Term
| What 3 things aggravate FS? |
|
Definition
o sleep deprivation
o stress
o fatigue |
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|
Term
| What is speculated to be the cause, although not yet confirmed? |
|
Definition
| Substance P sensitivity - SubsP is linked with pain,so SubsP sensitivity means a stimulus will feel painful even though the action is not physically harmful |
|
|
Term
| What 2 things are used to treat FS? |
|
Definition
- NSAID
- SSRI's (serotonin reuptake inhibitors) |
|
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Term
|
Definition
| Serotonin inhibits pain in neurons |
|
|
Term
|
Definition
|
|
Term
| What two things contribute to MG? |
|
Definition
- Ab to ACh receptor at NMJ
- Thymus hyperplasia |
|
|
Term
| Which sex is more susceptible? |
|
Definition
|
|
Term
|
Definition
| Muscle weakness, seen initially in the face |
|
|
Term
|
Definition
- Muscle weakness
- Diplopia
- Ptosis
- Facial droop
- Difficulty swallowing |
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|
Term
| What can induce myasthenia crisis? |
|
Definition
|
|
Term
| What 3 tests are used to diagnose? |
|
Definition
- ACh Ab (not definitive)
- EMG
- Tensilon |
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|
Term
|
Definition
| Short acting cholinomimetic |
|
|
Term
|
Definition
| Muscle responsiveness to electrical stimulation |
|
|
Term
| List the 4 treatment options for MG |
|
Definition
◦ AChE inhibitors
◦ thymectomy
◦ immunosuppressants
◦ plasmapheresis |
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