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Muscoloskeletal Pathophysiology - Joints
Pathology of the Muscoskeletal system
52
Physiology
Undergraduate 3
12/13/2013

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Cards

Term
Name 3 types of bone joining
Definition
1. Synarthsoes
2. Amphiarthoses
3. Diarthoses
Term
Describe Synarthsoes and list an example
Definition
- Immovable
- Fibrous tissue connecting bones
Term
Describe Amphiarthroses and list an example
Definition
- Slightly moveable
- Hyaline cartilage
Term
Describe Diarthoses and list an example
Definition
- Freely moving
- Any synoival joint
Term
What lies on the articular surface of bone at synoival joints?
Definition
Hyaline cartilage
Term
What is the synoival membrane? What is its purpose?
Definition
The connective tissue housing the joint; encases the synoival fluid
Term
What is the synoival fluid and what is its purpose?
Definition
Fluid filling the synoival cavity - nourishes joint cartilage and provides cushioning
Term
(T/F) Syn fluid has a high glycoprotein content
Definition
True
Term
What are bursa, and what is their function?
Definition
Sacs of syn fluid - created by constant movement; provide cushion
Term
What is the function of a tendon, and what is it called when it tears?
Definition
- Connects muscle to bone
- A strain
Term
What is the function of a ligament, and what is it called when it tears?
Definition
- Connects two bones (stabilizes joints)
- A sprain
Term
Why do sprains not heal well?
Definition
Because ligament have poor blood supply
Term
Name two types of injury that can occur involving bone and muscle
Definition
1. Dislocation
2. Repetitive strain
Term
What is subluxation?
Definition
A partial dislocation
Term
What is avulsion?
Definition
The separation of ligament/tendon from bone
Term
(T/F) Carpal tunnel syndrome is an example of a repetitive strain injury
Definition
True
Term
What occurs with this injury?
Definition
Friction on nerves around the joint causes a pain sensation.
Term
Why can this injury occur?
Definition
Because nerves are most exposed at joints
Term
Name 3 types of spinal abnormalities
Definition
1. Kyphosis
2. Lordosis
3. Scoliosis
Term
What is kyphosis?
Definition
Increased convexity of the thoracic spine
Term
What are 3 known causes?
Definition
o osteoporosis
o tuberculosis
o adolescence
Term
How does tuberculosis cause kyphosis?
Definition
Can enter the bones and deteriorate bone structure
Term
What is lordosis?
Definition
Increased curvature of the lumbar spine
Term
What is a common cause?
Definition
Diabetes
Term
What is the main cause of lordosis?
Definition
Obesity
Term
What is scoliosis?
Definition
Sideways curvature of the spine
Term
(T/F) There is both structural and functional scoliosis
Definition
True
Term
(T/F) Structural scoliosis usually has a known origin
Definition
False, it is mostly iodopathic
Term
List two other factors that could cause structural scoliosis
Definition
1. Congenital defects
2. Degenerative
Term
What is functional scoliosis?
Definition
Scoliosis caused by another functional pathology, NOT because of spinal structure
Term
Name 3 causes of functional scoliosis
Definition
o muscular dystrophy
o cerebral palsy
o trauma
Term
List the 2 causes of RA
Definition
1. General susceptibility - some people are jsut more likely to get it
2. Immune susceptibility
Term
What is seen in the immune predisposition?
Definition
Rheumatoid factor gets attacked by Ab specific to self Ag
Term
Describe the progression of RA?
Definition
1. Synovitis
2. Pannus
3. Cartilage erosion
4. Fibrosis
5. Ankylosis
Term
What is synovitis?
Definition
Inflammation and infection of the synoival fluid
Term
What is pannus?
Definition
Granulation tissue where there should not be tissue - can lead to tissue erosion (cartilage) and expose the naked bone
Term
What is ankylosis?
Definition
Joint fixation, caused by fibrosis
Term
(T/F) Small joints are affected last with RA
Definition
False, they are affected first
Term
List the signs of RA
Definition
Term
What does joint disuse lead to?
Definition
Muscular atrophy
Term
What is subluxation? Where is it often seen in RA?
Definition
Joint displacement - in the hands and thumb
Term
What is a boutonniere deformity?
Definition
Deformity of the fingers and toes, where the joint closest to the knuckle displays constant flexion, and the joint furthest is hyperextended
Term
List the 2 ways that juvenile RA is different from adult form?
Definition
1. Acute onset, especially in large joints
2. NO RF
Term
What is often seen in JRA?
Definition
Anti-nuclear antibodies
Term
List the systemic effects of JRA?
Definition
1. Rash
2. Fever
3. Enlarged spleen
4. Uveitis (iris inflammation)
Term
(T/F) JRA has over a 50% remission rate
Definition
True
Term
What 3 factors contribute to gout, and who is most likely to get this disease?
Definition
- Men over 40
- Factors
o age
o obesity
o alcohol use
Term
What happens in Gout?
Definition
Uric acid crystals accumulate in synoival fluids (especially the big toe)
Term
What causes uric acid accumulation?
Definition
- Excess purine breakdown
- Poor elimination of urea
Term
What does uric acid accumulation cause to develop?
Definition
Tophi
Term
What are tophi?
Definition
Depositions of uric acid crystals that form the noticeable lump in gout
Term
List the 4 treatment methods
Definition

- Diet

- Increased fluid and urine pH

- Allopurinol

- Colchine

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