Term
| two types of muscle relaxants & SE |
|
Definition
depolarizing (e.g. succinylcholine) --> hypercalcemia & hyperkalemia & malignant hyperthermia in people w/ mutated ryanodine receptors
nondepolarizing ("-curonium" or "-curarine", e.g. tubocurarine (curare)) --> rare seizures in liver toxicity |
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Term
|
Definition
Depolarizing muscle relaxant:
Phase I: prolonged depolarization (no antidote)
Phase II: repolarized but blocked (antidote = cholinesterase inhibitors, e.g. neostigmine) |
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Term
| Tx for succinylcholine/inhaled anesthetic-induced malignant hyperthermia? |
|
Definition
Dantrolene
(N2O is only inhaled anesthetic that DOESN'T cause MH) |
|
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Term
|
Definition
| prevents Ca++ release from SR (probably binds ryanodine receptor) |
|
|
Term
| BALSA of parkinson's drugs |
|
Definition
- Bromocriptine
- Amantadine
- Levodopa
- Selegiline
- Antimuscarinics (benztropine, diphenhydramine, trihexyphenidyl) |
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Term
|
Definition
|
|
Term
|
Definition
| ropinirole (preferred over non-ergots, e.g. bromocriptine, pergolide, pramipexole) |
|
|
Term
|
Definition
| increases dopamine release (& blocks M2 protein on influenza responsible for uncoating) |
|
|
Term
|
Definition
Amantadine
(mottled skin, looks like basketweave pattern of pigmentationto me) |
|
|
Term
| Converted to dopamine in CNS by aromatic amino acid decarboxylase (AAAD) |
|
Definition
|
|
Term
|
Definition
| inhibits MOA-b in periphery (prevents premature conversion of Levodopa to DA by AAAD before CNS penetration) |
|
|
Term
| peripheral MAO-b inhibitor |
|
Definition
|
|
Term
| Catechol-O-methyl transferase inhibitors (2) |
|
Definition
Tolcapone
Entacapone
(COMT converts levodopa to 3-O-methydopa) |
|
|
Term
|
Definition
| COMT inhibitor (levodopa metabolism in periphery & CNS) |
|
|
Term
|
Definition
| COMT inhibitor (levodopa metabolism in periphery & CNS) |
|
|
Term
| what do anitmuscarinics do in parkinsons treatment regimens? |
|
Definition
| improve tremor & rigidity, but has no effect on bradykinesia |
|
|
Term
| in parkinsons: improves tremor & rigidity, but no effect on bradykinesia |
|
Definition
| antimuscarinics (e.g. benztropine) |
|
|
Term
| Tx for essential or familial tremors |
|
Definition
| Beta-blocker (propranolol) |
|
|
Term
|
Definition
|
|
Term
| Levodopa/carbidopa toxicities |
|
Definition
| arrhythmias (DA --> hypotension --> reflex tachycardia) |
|
|
Term
|
Definition
| peripheral AAAD inhibitor (always given with levodopa) |
|
|
Term
| alwasy given with levodopa |
|
Definition
|
|
Term
| three inhitors given to increase dopamine |
|
Definition
Carbidopa (peripheral AAAD)
Tolcapone (central COMT)
Selegeline (selective MAO-b, acts centrally) |
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|
Term
|
Definition
| NMDA receptor antagonist used in alzheimers; helps prevent Ca++ mediated excitotoxicity |
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|
Term
|
Definition
Alzheimer drug:
Acetylcholine esterase inhibitor (central acting) |
|
|
Term
|
Definition
Alzheimer drug:
Acetylcholine esterase inhibitor (central acting) |
|
|
Term
|
Definition
Alzheimer drug:
Acetylcholine esterase inhibitor (central acting) |
|
|
Term
| blocks NMDA receptors & helps prevent Ca++ excitotoxicity in alzheimer's |
|
Definition
|
|
Term
| Central ACh inhibitors in alzheimers |
|
Definition
Donepezil
Galantamine
Rivastigmine |
|
|
Term
| Donepezil, galatamine, rivastigmine SE |
|
Definition
| nausea, dizziness, insomnia |
|
|
Term
| neurotransmittor levels in huntingtons |
|
Definition
increased dopamine, decreased GABA & ACh
(use reserpine + tetrabenazine = amine depleting;
& typical antipsychotic (haloperidol) = dopamine antagonist) |
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Reserpine, tetrabenazine, & haloperidol
(act to decrease dopamine & other amines) |
|
|
Term
| reserpine, tetrabenazine, & haloperidol |
|
Definition
| drugs used in huntingtons |
|
|
Term
|
Definition
5HT1b/1d agonist --> vasoconstriction --> migraine relief
(1/2-life = <2hrs)
used in acute migraines & cluster headaches |
|
|
Term
| Sumatriptin contraindications |
|
Definition
|
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