Term
| What drugs are used to treat Spasticity? |
|
Definition
Baclofen
Dantrolene
Tizanidine
Quinine |
|
|
Term
| What Drugs are used to treat muscle Spasm? |
|
Definition
Carisoprodol
Chlorzoxazone
Cyclobenzaprine
Metaxalone
Methocarbamol
Orphenadrine
Pregabalin |
|
|
Term
| What agent acts as a GABA-B agonist? What does this produce? |
|
Definition
Baclofen
produces inhibitory signals or hyperpolarizing and reducing the excitatory polysynaptic pathways |
|
|
Term
| What is Baclofen Indicated for? |
|
Definition
Multiple Sclerosis
Muscle Spasm
Spasticity
Spinal cord trauma |
|
|
Term
| What agent decreases the number and severity of spasms, decrease pain and rigidity, and improves bowel/bladder function? |
|
Definition
|
|
Term
| What causes pain relief in the spinal cord from Baclofen use? |
|
Definition
| inhibition of action of substance P |
|
|
Term
| Who should avoid Baclofen? Why? |
|
Definition
Patients with impaired renal function
Renally eliminated, drug accumulation can lead to encephalopathy, abdominal pain, seizures, respiratory depression |
|
|
Term
| What can occur if Baclofen is abruptly discontinued? |
|
Definition
Rebound Neural activity
Seizures, confusion, hallucinations, psychiatric disturbances, increased spasticity |
|
|
Term
| Why must the dose of antidiabetic agents be adjusted with Baclofen use? |
|
Definition
| Baclofen increases blood glucose |
|
|
Term
| What drug is used to treat Malignant hyperthermia and neuroleptic malignant syndrome? |
|
Definition
|
|
Term
| How does Dantrolene prevent intracellular calcium release? |
|
Definition
| Blocks the ryanodine receptor - the major calcium release channel in skeletal muscle sarcoplasmic reticulum. |
|
|
Term
| What agent can cross the placenta and produce "floppy child syndrome" if used during Cesarean section? |
|
Definition
|
|
Term
| What agent is a pre-synaptic alpha2 receptor agonist? What does this produce? |
|
Definition
Tizanidine
decreased activation of polysynaptic spinal cord motor neurons -> reduction in muscle tone but NOT muscle strength. |
|
|
Term
| What Spasm Tx drug has action in the CNS and Cord? |
|
Definition
|
|
Term
| What agent is an analogue of GABA that binds the alpha-2-delta subunits of calcium channels, reducing neuronal calcium currents? |
|
Definition
|
|
Term
| What agent has Anticholinergic effects? |
|
Definition
|
|
Term
| What drug interaction do all of the muscle relaxants have in common? |
|
Definition
|
|
Term
| What Spasm drug is metabolised by CYP2C19? |
|
Definition
Carisoprodol
Plasma levels decreased by Inducing agents - Rifampin or carbamazepine
Plasma levels increased by inhibitors - ketoconazole or fluoxetine |
|
|
Term
| What drug is approved for fibromyalgia treatment? |
|
Definition
|
|
Term
| What 3 agents need to have the dose adjusted with renal insufficiency? |
|
Definition
Baclofen
Tizanidine
Pregabaline |
|
|
Term
| What drug can cause CV collapse when used with CCBs, and hepatic toxicity if used with estrogen? |
|
Definition
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