Term
| 2 types of anti-muscarinics |
|
Definition
Natural alkaloids
Quaternary amines |
|
|
Term
| Natural alkaloid absorption and distribution |
|
Definition
tertiary drug
cross BBB (Scoploamine) |
|
|
Term
| Quaternary amines (Ipratropium) |
|
Definition
poorly absorbed
does NOT cross BBB- little CNS effects |
|
|
Term
| Musc. blocker Mech of Action |
|
Definition
less effective against ACh released at effector cells
selective for mAChR over nicotinic (exception-QUATERNARY) |
|
|
Term
| This is highly sensitive to atropine |
|
Definition
|
|
Term
| this is relatively insensitive to atropine |
|
Definition
|
|
Term
| Intermediate dose of Atropine produces |
|
Definition
| drowsiness, impaired memory and concentration |
|
|
Term
| High dose of Atropine produces |
|
Definition
| confusion, excitement, hallucination, convulsions |
|
|
Term
|
Definition
| paralysis, coma, resp. failure, circ. collapse |
|
|
Term
| Common dose of Scopolamine |
|
Definition
| drowsiness, amnesia, fatigue, and reduction in REM sleep |
|
|
Term
| higher dose of scopolamine |
|
Definition
|
|
Term
| This is used to treat motion sickness |
|
Definition
|
|
Term
| Atropine effect on pupillary sphincter |
|
Definition
| mydriasis and photophobia |
|
|
Term
| Atropine effects on Ciliary muscle |
|
Definition
| cyclopegia, blurred vission, incr. resistance to aqueous outflow |
|
|
Term
| atropine effects on lacrimal glands |
|
Definition
| decreased tear production |
|
|
Term
| muscarinic blocker LOW dose on heart |
|
Definition
| decrease in HR; High dose-->TACHYCARDIA, BP same |
|
|
Term
| Atropine effect on vasculature |
|
Definition
cutaneous vasodilation
hyperthermia- from decreased sweating |
|
|
Term
| Atropine on respiratory system |
|
Definition
M3- dilation and decr secretion
M2- opposite
Really helpful for COPD patients |
|
|
Term
|
Definition
| causes dry mouth; opposite of PS |
|
|
Term
|
Definition
low doses- inhibit sweating
higher doses- increases body temperature |
|
|
Term
| Atropine has a long half life in which organ |
|
Definition
Eye- cyclopegia
used to examine disorders of accomodation |
|
|
Term
|
Definition
| Ipratropium and Tiotroprium |
|
|
Term
| Inhaled quaternary amine drugs do what on resp tract |
|
Definition
| minimize systemic side effects |
|
|
Term
|
Definition
does NOT impede mucociliary transport
blocks ACh (M2) |
|
|
Term
|
Definition
Prefers M1/3 over 2
Longer duration of action |
|
|
Term
| Two drugs used urologically |
|
Definition
| Oxybutynin and tolterodine |
|
|
Term
| Side effects of Oxybutynin |
|
Definition
|
|
Term
|
Definition
slight pref to M2 receptors
relaxation is mediated more by M3 receptors. |
|
|
Term
| This urological drug reduces dry mouth compared to the other two |
|
Definition
|
|
Term
| 2 anti-Mus. used in digestive tract |
|
Definition
| methscopolamine and pirenzepine |
|
|
Term
| This tertiary drug is used when L-dopa is contraindicated |
|
Definition
|
|
Term
|
Definition
| severe bradycardia, and hypotension |
|
|
Term
| This drug is used IV to decrease upper respiratory secretion |
|
Definition
|
|
Term
| Anti-mus contraindications |
|
Definition
| closed angle glaucoma, GI obstruction |
|
|
Term
| Anticholinergic poisoning can occur from |
|
Definition
ingestion of nightshade, Jimson weed
OTC abuse of belladonna alkaloids |
|
|
Term
|
Definition
Homatropine, Tropicamide
OTC abuse of belladonna alkaloids |
|
|
Term
| Side effects of anti-cholinergics |
|
Definition
| Blindness, psychosis, flushed, dry, hot |
|
|
Term
| This drug is absorbed through the skin |
|
Definition
|
|
