Term
|
Definition
| Stabalizes lysosomes and decrease chemotaxis |
|
|
Term
| Hydroxychloroquine Side Effects |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Best medicine to use for MILD Rheumatoid arthritis, and Medicine to use for more moderate to severe cases |
|
Definition
Hydroxychloroquine
Methotrexate |
|
|
Term
| Sulfasalazine Side Effects (3) |
|
Definition
| G6PD, SLE like syndrome, GI distress |
|
|
Term
| Drug used for Wilson's and RA |
|
Definition
|
|
Term
|
Definition
| Suppress T cells and circulating Rheumatoid factor |
|
|
Term
|
Definition
| Binds tumor necrosis factor, is a recombinant form of TNF receptor. (-cept) |
|
|
Term
|
Definition
| Monoclonal Antibody to TNF |
|
|
Term
|
Definition
| Inhibits dihydro-ortotic acid dehydrogenase -> decrease dUMP -> decrease ribonucleotides ->arrests lymphocytes at G1 |
|
|
Term
|
Definition
|
|
Term
| Aspirin effects on Uric ACID |
|
Definition
Low/Mod- hyperuricemia
High- uricosuria |
|
|
Term
| Aspirin in Acid/Base problems |
|
Definition
High dose- mild uncoupling of the proton gradient causing decrease in ATP, incraese in respiration which decreases carbon dioxide levels causing respiratory alkalosis
Toxic dose- inhibits respiratory center which increases carbon dioxide levels and a respiratory acidosis |
|
|
Term
| What to do for an overdose of Aspirin |
|
Definition
| Alkalinize the urine and increase the urine volume |
|
|
Term
| What meds are able to slow down Rheumatoid arthritis |
|
Definition
|
|
Term
|
Definition
| PTH analog used once daily but may increase the risk for osteosarcoma |
|
|
Term
|
Definition
| Irreversibly inhibits COX1 and COX2 by acetylation of serine active site |
|
|
Term
| Aspirin clinical uses by dosage |
|
Definition
Low: antiplatelet aggregation
Int: antipyretic and analgesic
High: anti-inflammatory |
|
|
Term
| Aspirin increase and decreases the effects of which drugs |
|
Definition
increase: sulfonyulurea/warfarin
decrease: Uric Acid drugs (allopurinol) |
|
|
Term
|
Definition
Gastric Ulcers
Acute renal failure in chronic use
Bronchospasm in Asthma
Reye's
Tinnitus
Hyperventilation |
|
|
Term
|
Definition
Ibuprofen: Inflammation
Naproxen: Gout
Indomethacin (most potent): Close PDA
Ketorolac: Best analgesic
Sulindac- Renal Issues but causes Steven Johnson's |
|
|
Term
|
Definition
| Reversible inhibitor of COX-1/COX2 |
|
|
Term
|
Definition
Celecoxib and Refecoxib
Reversibly inhibits COX2 wich is found inflammatory cells and vascular endothelium |
|
|
Term
|
Definition
| RA, osteoarthritis (especially in patients with gastric ulcers) |
|
|
Term
|
Definition
Increase thrombosis (Loss of antiplatelet)
Sulfa Drug |
|
|
Term
| Acetominophen MOA, what does it lack when compared to other NSAIDS, and what is the antidote |
|
Definition
Inhibits cox mostly in the CNS
Lacks anti-inflammatory
N-acetylcysteine for hepatic necrosis |
|
|
Term
|
Definition
| Inhibit osteoclast activity, reduce both formation and resorption of hydroxyapatite. |
|
|
Term
| Biisphosphonates Uses and 2 Side effects |
|
Definition
Pagets
Postmenopausal Osteoporosis
Glucocorticoid Osteoporosis
SE: corrosive esophagitis and osteonecrosis of the jaw |
|
|
Term
|
Definition
| Inhibits reabsorption of Uric Acid in the PCT, inhibits excretion of weak acids |
|
|
Term
|
Definition
| Crystalization- uric acid renal stones |
|
|
Term
| Allopurinol and Febuxostat MOA |
|
Definition
Inhibits xanthine oxidase and decreases conversion of xanthine to uric acid.
Also increases concentration of 6-MP and azathioprine |
|
|
Term
|
Definition
Binds and stabilizes tubulin to inhibit polymerization
Used in Acute Gout (now usually give NSAID instead) |
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