Term
Deacetylated but does not require enzymes (unlike codein)
Also has M3G and M6G metabolites |
|
Definition
|
|
Term
| Fast crossing the BBB, Euphoria after a couple hours, rapid withdrawal |
|
Definition
|
|
Term
|
Definition
Miosis, Come, Respiratory Distress
other: pulmonary edema, and seizures |
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|
Term
| Amphoteric and has a hard time crossing the BBB, (low lipid solubility) u receptor affinity. low affinity for s and k |
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Definition
|
|
Term
| MG6 has a high u1 affinity which exceeds the potency of the drug pre-metabolism |
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Definition
|
|
Term
| Indicated for severe pain, adjunct in anesthesia |
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Definition
|
|
Term
| First Pass effect, respiratory depression, constipation, additive, convulsions, rigidity, nausea, asthma, |
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Definition
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|
Term
| Do not take what drug with renal or liver problems |
|
Definition
|
|
Term
| Semisynthetic with higher potency, more sedation, and less euphoria than Morphine |
|
Definition
|
|
Term
| Can be used in lollipop, patch, transdermal forms |
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Definition
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|
Term
| Redistributes in Fat and muscle, 100x more potent than morphine |
|
Definition
|
|
Term
| Used for epidurals for sedation and anasthesia |
|
Definition
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|
Term
| Rapid onset, pridictable, and is used for quick surgical operations with NO. Titrated |
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Definition
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|
Term
| Short Duration used as an analgesia during child birth. Titrated |
|
Definition
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|
Term
| Intranasal form of fentanyl and 5x more potent used for mod/severe pain |
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Definition
|
|
Term
| Blocks neuronal uptake of NE and Serotonin |
|
Definition
|
|
Term
| Binds to presynaptic NMDA receptors |
|
Definition
|
|
Term
| Used for severe pain and maintenance in rehab programs |
|
Definition
|
|
Term
| Has a 10 day metabolization with a 25-50 hour half life |
|
Definition
|
|
Term
| has + anticholinergic effects including tachycardia |
|
Definition
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|
Term
| Used in severe pain, adjunct in anesthesia, does not cause constipation. 1/10 potency of morphine. Contraindicated in renal failure with less peripheral sides |
|
Definition
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|
Term
| Prodrug of morphine with a methyl group attached. Higher lipophilicity. Like morphine it competes with other agonists |
|
Definition
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|
Term
| Not effective in 10% of ppl due to CYP2D6 |
|
Definition
|
|
Term
| Comes from codeine and thebaine for moderate pain |
|
Definition
|
|
Term
| Ibuprophen and Hydrocodone |
|
Definition
|
|
Term
| Acetominophen + hydrocodone |
|
Definition
| Lortab, vicodin, lorcet, norco |
|
|
Term
| Partial u agonist and k antagonist |
|
Definition
|
|
Term
| Similar to strong agonist, but can antagonize their effects; alcohol cravings |
|
Definition
|
|
Term
| k agonist and u antagonist |
|
Definition
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|
Term
| Used in rehab programs, severe pain, ceiling effect for depressed ventilation but not analgesia |
|
Definition
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|
Term
| May precipiate withdrawal, hard to reverse, poor bioavailability |
|
Definition
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|
Term
| Ceiling effect and can reverse depressed ventilation. Used for renal colic, migrains, cancer, surgery |
|
Definition
|
|
Term
| Antagonist of u s and k. antagonizes opioid effects |
|
Definition
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|
Term
| Used for opioid overdose or repiratory distress |
|
Definition
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|
Term
| Small dosage divided and titrated to preserve analgesia and decrease whthdrawal |
|
Definition
|
|
Term
| Mixed effects; weak u agonist, moderate sert/ne inhibitor |
|
Definition
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|
Term
| Can cause seizures, with little addiction. Used as an adjunct for chronic pain syndromes |
|
Definition
|
|
Term
| Bioavailability 60-80% oral. equinalgesic with morphine. For pain in cancer patients and is highly abused |
|
Definition
|
|
Term
| Oxycodone + acetaminophen |
|
Definition
|
|
Term
|
Definition
|
|
Term
| u and k antagonist, detoxify harden addicts. decrease craving of alcohol |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| isoquinolones, Long onset (4-6 hours), Long duration (80-120hours), renal elimination |
|
Definition
|
|
Term
| Causes hypotension due to histamine release at high concentrations can cause ganglionic block |
|
Definition
|
|
Term
| isoquinolones, short duration with hydroslysis metabolsm |
|
Definition
|
|
Term
| Muscle relaxant which causes bradycardia |
|
Definition
|
|
Term
| steroid, long duration (120-180), Renal elimination |
|
Definition
|
|
Term
| Moderate increase in heart rate and cardiac output due to cardiac muscarinic blockade |
|
Definition
|
|
Term
| Steroid, intermediate duration, liver elimination |
|
Definition
|
|
Term
| New, fastest onset for tracheal intubation, no tachycardia |
|
Definition
|
|
Term
| Depolarizing agent, ultra short duration, with plasma cholinesterase diffusion metabolism |
|
Definition
|
|
Term
| A receptor agonist, 2 Ach's end to end, fast with short duration |
|
Definition
|
|
Term
| Reverses Non-depolarizing/depolarizing (phase 2) drugs |
|
Definition
| Neostigmine/physostigmine |
|
|
Term
| Can be used in patients with multi organ failure due to independent function of metabolism |
|
Definition
| Atracurium /cisatracurium |
|
|
Term
| Non-depol drug interaction with cholinesterase inhibitors |
|
Definition
|
|
Term
| Non-depol drug interaction with aminoglycosides |
|
Definition
|
|
Term
| Calcium channel blocker with Non-depol drug interaction |
|
Definition
|
|
Term
| Anesthesia + non depol drug interaction |
|
Definition
|
|
Term
| Can be used to reduce fasciculation of Phase one depolarizing block |
|
Definition
|
|
Term
| Anti cholinesterase + depolarizing drug block |
|
Definition
| Increases phase 1 block, reverses phase 2 block |
|
|
Term
| Non depolarizing agents are what for depolarizing agents |
|
Definition
|
|
Term
| Causes malignant hyperthemia when added to a depolarizing agent |
|
Definition
|
|
Term
| Increase GABA inhibition on GABAa |
|
Definition
| Bezediazepines(diazapam-valium) |
|
|
Term
| Inhibit pirmary motor neurons, it is long acting in chord transsections |
|
Definition
| Benzadiazepines (diazapam) |
|
|
Term
|
Definition
|
|
Term
| A benzadiazepines causing drowsiness |
|
Definition
|
|
Term
| Internally acting with active metabolites. A benzadiazepine given to the elderly |
|
Definition
|
|
Term
|
Definition
|
|
Term
| MOA: increase K+ and hyperpolarization, decreases substance P |
|
Definition
|
|
Term
| Less sedation than benediazapines, relieves spastic pain |
|
Definition
|
|
Term
| Causes drowsiness and increased seizures in epeleptics |
|
Definition
|
|
Term
| Increases GABA and is used as an anti-convulsant, decrease muscle spasms |
|
Definition
|
|
Term
| Glutamate antagonist exerts spasmolytic effects |
|
Definition
|
|
Term
| Used for Amyotrophic Lateral Sclerosis increasing survival |
|
Definition
|
|
Term
| alpha 2 agonist used for MS and spinal cord injury |
|
Definition
|
|
Term
| Side effects include dry mouth and drowsiness |
|
Definition
|
|
Term
| Acts on the brain stem for localized spasms in the lower back |
|
Definition
| Cyclobenzaprine (chloraxazone or orphenadrine) |
|
|
Term
| Causes sedation and hallucinations due to antimuscarinic effects |
|
Definition
| Cyclobenzaprine (chloraxazone or orphenadrine) |
|
|
Term
| Blocks ryanodine receptors on SR, Reduces muscle contraction. For MALIGNANT HYPERTHERMIA |
|
Definition
|
|
Term
| Used for muscle spasm/contraction in facial expression. Also cerebral palsy |
|
Definition
|
|
Term
| A sedative/hypnotic drug with additive effects to alcohol causing repiratory distree. Can be used if Benzadiozepines can't. Has addiction and withdrawal |
|
Definition
|
|
Term
| NE and 5HT reuptake inhibitor, used for post hepatic neuraldia, diabetic neuropathy and sleep. Anticholinergic sides |
|
Definition
|
|
Term
| Used in Fibromyalgia, lower back pain, and diabetic neuropathy |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Modulation of Ion channel, inhibiting Na+ and presynaptic inhibition. Used for Trigeminal Neuralgia |
|
Definition
|
|
Term
| MOA: GABA metabolism. Calcium inhibition, glutamate and sub P decrease. Decrease in hyperexcited neurons. Used in PHN,MS,ALS,Phantom Limb, Spinal Cord |
|
Definition
|
|
Term
| A greater potency of Gabapentin and used #1 for Fibromyalgia |
|
Definition
|
|
Term
| Blocks Na+ channels found in Trandemal or oral form |
|
Definition
| Transdermal (lidocain) oral (Mexiletin) |
|
|
Term
| A cream to decrease Substance P in the skin used for external skin pain |
|
Definition
|
|
Term
| Vitamin D administration for osteoporosis level |
|
Definition
| 40-60 ng/ml (high dose monitoring) |
|
|
Term
| Vitamin D administration for a person with CAD |
|
Definition
|
|
Term
| Vitamin D administration for a person with Kidney problems |
|
Definition
|
|
Term
| Risks include breast cancer and CAD risks. Used in osteoporosis |
|
Definition
|
|
Term
| Neutralizes effect on endometrial cancer |
|
Definition
|
|
Term
| A serm used for osteoporosis. Risks include DVT and pulmonary embolism |
|
Definition
|
|
Term
| Treat woman 5 years post menopause. Intranasal and improves efficacy of biphophanates |
|
Definition
|
|
Term
| 1st line treatment for osteoporosis with efficacy decreasing overtime. |
|
Definition
|
|
Term
| Weekly PO for biphosphonates |
|
Definition
| Alendronate + Risedronate |
|
|
Term
| Monthly PO for biphospoanates |
|
Definition
| Risedronate + Ibandronate |
|
|
Term
|
Definition
| Ibandronate or Zoledronic acid (yearly) |
|
|
Term
| Monoclonal AB against RANKL so it doesn't bind to osteoclasts. SUBQ injection every 6 months |
|
Definition
|
|
Term
| NSAID used in Spndyloarthropathy |
|
Definition
|
|
Term
| Axial disease with +HLA B-27 |
|
Definition
INF alpha inhibitors: Enbrel, Humra, Remicaid, 6-MP
USE CARE WITH IBD |
|
|
Term
| What drugs are used for psoriasis |
|
Definition
|
|
Term
| Peripheral disease of spondylarthropathy |
|
Definition
DMARDS: Sulfasalazine (Azulifidine)
Methotraxate
Minocin, plaqueinil, Gold, Inuran, cycosporine |
|
|
Term
| Special skin cases of spondylarthropathy |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Fibromyalgia inhibit stimulator |
|
Definition
|
|
Term
| Fibromyalgia inhibit stimulator but not FDA approved |
|
Definition
|
|
Term
| Fibromyalgia Stimulatory inhibitor FDA approved for osteoarthritic chronic bakc pain. Also name another drug in this category |
|
Definition
Duloxetine (cymbalta)
another drug is Minacipran |
|
|
Term
| Acut treatment attack of gout |
|
Definition
|
|
Term
|
Definition
Probenecid/Sufinpyrazone
Allopurinol/Fubixostat
Uricase (Krystexxa) |
|
|
Term
| Renal complication in gout |
|
Definition
| Allopurinol, Fubixostat, Uricase |
|
|
Term
| Gout drug given IV every 2 week. Need to avoid G6PD deficiency and possible anaphylaxis |
|
Definition
|
|
Term
| Xanthine Oxidase Purine analogue |
|
Definition
|
|
Term
| Xanthine Oxidase non-purine XO inhibitors |
|
Definition
|
|
Term
| Gout drugs which increase renal clearance urate/increase urine urate. Decrease serum urate, will not work if urine uric acid levels are high or renal problems |
|
Definition
|
|
Term
|
Definition
NSAIDS
Colchicine
Steroids |
|
|
Term
| Gouty drug wich causes renal/liver problems. Prophylactic use or acute use using a pill every 2 hours |
|
Definition
|
|
Term
| Drugs used for Osteomyelitis infection Diabetes foot polymicrobial infection |
|
Definition
Ampicillium-sulbactum
Pipercillin-tazobactum
Carbapenems
Clyndamycin
Metronidazole +Betalactam
Vancomycin |
|
|
Term
| Boxers fracture infection of Pasteurella Multocida/Eikenella corrodens |
|
Definition
| Amoxacillin and clavulanate |
|
|
Term
| If you have an allergy to amoxacillin and clavulanate for a P. multocida infection use: |
|
Definition
|
|
Term
| Nail infection with Pseudomonas aeuruginosa drugs |
|
Definition
| Ciprofloxacin/Cefraxidime |
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|
