Term
|
Definition
| used to image Periventricualr and juxtacrotical elsions. FLAIR |
|
|
Term
|
Definition
| demyelingatino follwoed yb later axona ldegeneration, and plaque formation |
|
|
Term
|
Definition
| occur on average once a year in untreated patients , relaspeh ast o bem ore than 24 hour ocurence |
|
|
Term
|
Definition
| average 1 lrelapse per yera , most never have dls deilitated. Rarely death as primary cause |
|
|
Term
| clnically isoalted sydnrome |
|
Definition
| one isoalted atack of MS, not clnically edefinite until get a second unrelated attakc. may return to baseline between atacks |
|
|
Term
|
Definition
| have between clinidcaly definite ms and secodn progregsisve ms |
|
|
Term
|
Definition
| you continue too have stymtpoms and dont return toe baseline after atack |
|
|
Term
|
Definition
| from the outsidey ou dont go back down to baseline stay up |
|
|
Term
|
Definition
| based on clincial diagnosis. NEed to have at least one clincia lattack clnicaly isoalted syndrome) and another attack isoalted in time and space , with ms like causes excluded |
|
|
Term
| Clincialy isoalted sndrome lastign |
|
Definition
| needs tobe mroe than 24 hours |
|
|
Term
| major presenting sytmpsom fo first attack ms |
|
Definition
| sensory loss in limbs, visual loss, motor |
|
|
Term
|
Definition
| can diagnoe with oen clinical attack plus a second, OR presences of T2 weighted lesions in characteristic ms lesions such as spinal cord , psoerior fossa, periventricular , juxtacortical areas |
|
|
Term
| primary progressive criteria |
|
Definition
| at least one year of diseasep rogresison bltu 2/3: lesions in the brain t2. lesiosn in spinal cord (dissemianted). or positive csf |
|
|
Term
|
Definition
| hypoinetnese .t2 lesions- show total burden of disease, flair suppress csf to see subcortical orcorical elsion id. Gadolinium- highlights new and active leison s |
|
|
Term
| ms lesions apepar beore lcinical symptoms |
|
Definition
|
|
Term
| 7t mri useful for cortical lesiosn |
|
Definition
|
|
Term
|
Definition
|
|
Term
| mroe asymoptomatic lesiosn = mroe likely to progress to clnidicaly deifnit |
|
Definition
|
|
Term
|
Definition
| lymes dissease, sle, tumors, vitamin b2112 deficienceis , neurospyhphillis |
|
|
Term
|
Definition
| mmimcs ms. antibodies to aquapori n four, damge to BB and inflammaiton. On mri see long cord damge to spinal cord over mroe thean 3 segments |
|
|
Term
|
Definition
| oen time demyliatnion usually due to virsuses or vaccines. resovles on own. |
|
|
Term
|
Definition
| lyemdisease frequently indisgitnuishable from MS |
|
|
Term
| tabes dorsalisclassic syphillis sign |
|
Definition
|
|
Term
|
Definition
| more susceptible to Ms like syptoms |
|
|
Term
| acute ms relapsem anagement |
|
Definition
| high dose steroids, plasmashpherisis or ivig |
|
|
Term
|
Definition
| delayign course of hte disease, use of immunomodulating therapy, and immunosuppressants, statted soon after diagnosis |
|
|
Term
| fingolomdo only one not injected |
|
Definition
|
|
Term
|
Definition
| decreased th1 cells . Also reduced MMp and increases VCAM which binds toVLA4 receptor on th1 cells. |
|
|
Term
|
Definition
| bidns to vla4 receptor on th1 cells |
|
|
Term
|
Definition
|
|
Term
|
Definition
| modulas s1p receptor, itenralnlization in t cells so that it prevents t cel egress into cell |
|
|
Term
|
Definition
| only drug apropved for secondarily progresisve disease but leads to significatn cardiotoxicity |
|
|
Term
| incidence ofm ri lesions decreases after treatment |
|
Definition
|
|
