Term
| 2nd most common degenerative disorder |
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Definition
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Term
| does Parkinson's present with dementia? autonomic dysfunction? tauopathy? |
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Definition
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Term
| neurotransmitter tracks affected in Parkinson's |
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Definition
| substantia nigra, locus coeruleus |
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Term
| histological finding in Parkinson's |
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Definition
| alpha-synuclein+ Lewy bodies |
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Term
| mutations and inheritance pattern for familial Parkinson's |
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Definition
| autosomal dominant; mutations in LRRK2 or alpha-synuclein |
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Term
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Definition
| gait and balance instability (hyper-erect), paralysis of vertical gaze, dysphagia/dysarthria, dementia |
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Term
|
Definition
| globus pallidus degeneration |
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Term
| globose neurofibrillary tangles of tau with paired straight filaments; dx? |
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Definition
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Term
|
Definition
| asymmetric degeneration of post and pre-central gyri; thin corpus callosum |
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Term
| histological findings in CBD |
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Definition
| ballooned neurons, astrocytic plaques |
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Term
| Parkinsonism, autonomic dysfunction, glial cytoplasmic inclusions; dx? |
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Definition
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Term
| 3 syndromes of multisystem atrophy |
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Definition
| Shy-Drager, striatonigral, olivopontocerebellar atrophy |
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Term
| orthostatic hypotension, degeneration of inferior mediolateral cell column; dx? |
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Definition
| Shy-Drager multisystem atrophy |
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|
Term
| Parkinsonism with atrophy of putamen; dx? |
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Definition
| striatonigral multisystem atrophy |
|
|
Term
| Parkinsonism with inferior olivary nucleus atrophy; dx? |
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Definition
| olivopontocerebellar multisystem atrophy |
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|
Term
| muscle wasting, dysarthria, dysphagia, spasticity; no autonomic dysfunction, no cognitive dysfunction; dx? |
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Definition
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Term
|
Definition
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Term
| gross findings in Huntington's |
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Definition
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Term
| genetic cause of Huntington's disease |
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Definition
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|
Term
| biochemical cause of Huntington's |
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Definition
| decreased GABA levels in striatum |
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|
Term
| does PSP have autonomic dysfunction? |
|
Definition
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