Term
|
Definition
Inhibit the enzyme monoamine oxidase, which breaks down catecholamines, including 5HT, NE, EPI, DA. If these NT |
|
|
Term
| Brand name for isocarboxazid? |
|
Definition
|
|
Term
| Brand name for Phenelzine |
|
Definition
|
|
Term
| Brand name for Tranycypromine? |
|
Definition
|
|
Term
| Are these agents used commonly? |
|
Definition
Not commonly uesd by watch for drug - drug and drug - food interactions - if missed could be fatal |
|
|
Term
| Name significants of note for MOIs. |
|
Definition
Anticholinergic effects (taper upon d/c to avoid cholinergic rebound)
Orthostatic hypotension
Sedation (except for Tranylcypromine --> stimulation)
Sexual Dysfunction
Hypertensive crisis can occur whent aken with TCAs, SSRIs, SNRIs, many other drugs and tyramine - rich foods. |
|
|
Term
| Explain the washout period. |
|
Definition
2 week washout if going to or from a MAO inhibitor and an SSRI, SNRI, or TCA and antidepressant
Exception: fluoxetine back to MAOI need to wait 5 weeks.
|
|
|
Term
| Are MAOIs used with other drugs commonly? |
|
Definition
| MAOIs CANNOT be used with many other drugs - the drugs will not be broken down and hypertensive crisis, serotonin syndrome or psychosis may result. |
|
|
Term
| Must one watch the foods they eat while on MOAIs? |
|
Definition
MAOIs cannot be used with tyramine - rich foods, including aged cheese, pickeled herring yeast - extract, air- dried meats, sauerkraut, soy sauce and some red wines and beers.
Foods can become high in tyramine when they have been aged, fermented, pickled or smoked.
|
|
|
Term
| What are signs and symptoms of seratonin syndrome? |
|
Definition
agitation or restlessness, palpitations, diarrhea, hallucinations, feeling hot, loss of coordination, rapid changes in BP, and vomitting |
|
|
