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Molecular Therapeutics
Definitions
8
Immunology
Professional
04/02/2011

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Cards

Term
Gene Therapy
Definition
addition of a functional gene to produce a therapeutic protein for treatment of a disease
Term
Antigenes
Definition
single stranded oligonucleotides (DNA) that form triplex structure with double stranded DNA and block its transcription
Term
Decoys
Definition
double stranded oligonucleotides (DNA) that bind to nuclear transcription factor and inhibit gene transcription
Term
Antisenses
Definition
single stranded oligonucleotides (DNA or RNA) that bind to complementary mRNA and inhibit translation
Term
RNAi
Definition
RNA interference inhibiting translation of mRNA to protein by siRNA (small interfering double stranded RNA binding to complementary mRNA) or shRNA (short hairpen RNA transcribed from DNA)
Term
miRNA
Definition
micro RNA is non-coding double stranded RNA binding to 3'UTR of target mRNA and inhibiting its expression
Term
Ribozymes
Definition
RNA molecules that cut specific RNA substrate
Term
Aptamers
Definition
single stranded or double stranded oligonucleotides that bind to specific proteins and alter their function
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