Term
Miescher
-year?
-contribution? |
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Definition
-1868
-isolated an acidic substance, from pus, consisting mainly of phosphorus and nitrogen. He called this substance "nuclein" |
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Term
Griffiths
-year?
-contribution? |
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Definition
-1928
-discovered the "transforming principle" using S.pneumoniae injected into mice |
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Term
Sia and Dawson
-year?
-contribution? |
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Definition
-1931
-repeated the transformation experiment in vitro |
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Term
Avery, Macleod and McCarty
-year?
-contribution? |
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Definition
-1944
-used protease, DNase and RNase to demonstrate the "transforming principle" was DNA |
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Term
Hershey and Chase
-year?
-contribution? |
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Definition
-1952
-used radioactively labelled bacteriophage to demonstrate that DNA is the genetic material |
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Term
Watson and Crick
-year?
-contribution? |
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Definition
-1953
-proposed that DNA exists as a double-helix of polynucleotide chains |
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Term
Fraenkel-Contrat
-year?
-contribution? |
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Definition
-1957
-used the tobacco mosaic virus to show that RNA carried the genetic information in some viruses |
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Term
TRUE/FALSE
nucleic acids are polymers of nucleotides (nitrogenous bases, salt and phosphate group) linked together by a phosphodiester bond between the 5'OH group of one nucleotide and the 3'P group of another nucleotide |
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Definition
FALSE
nucleic acids are polymers of nucleotides (nitrogenous bases, SUGAR and phosphate group) linked together by a phosphodiester bond between 3'OH group of one nucleotide and the 5'P group of another nucleotide |
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Term
TRUE/FALSE
each strand of the double helix exhibits polarity, one end has a 5' phosphate group and the other a free 3' OH group |
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Definition
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Term
TRUE/FALSE
the two strands of the DNA double helix are complementary, parallel and held together by carbon bonds |
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Definition
FALSE
the two strands of the DNA double helix are complementary, ANTIPARALLEL and held together by HYDROGEN bonds |
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