Term
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Definition
| Double-membrane including outer membrane, inner membrane, and intermembrane space. |
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Term
| Outer Mitochondrial Membrane |
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Definition
| Highly permeable with porins, few membrane proteins |
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Term
| Inner Mitochondrial Membrane |
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Definition
| Where oxidative phosphorylation occurs, most membrane proteins here, highly impermeable. |
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Term
| Mitochondrial Intermembrane Space |
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Definition
| Stores protons used for ATP production |
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Term
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Definition
| Where the Citric Acid Cycle occurs as well as the conversion of pyruvate and fatty acids into Acetyl-CoA for use in the citric acid cycle. |
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Term
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Definition
| Act in concert to split or rearrange the intermediates and to move phosphate groups from one molecule to another such as ADP to ATP. These are the machinery that drive glycolysis. |
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Term
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Definition
| Located in the mitochondrial matrix. They facilitate the Citric Acid (Krebs) Cycle. The Citric Acid Cycle's purpose is to harvest energy from glucose which is converted to Acetyl-CoA prior to the Cycle. |
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Term
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Definition
| 2 Parts: F0 and F1. F0 located in Inner Mitochondrial Membrane, F1 is suspended into the Mitochondrial Matrix. ATP Synthase uses the power from a proton gradient to add an inorganic phosphate to ADP to produce ATP. |
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Term
| Glycerol Phosphate Shuttle |
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Definition
| Located in the Inner Mitochondrial Membrane. It is a secondary mechanism for the transport of electrons from cytosolic NADH to mitochondrial carriers of the oxidative phosphorylation. |
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Term
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Definition
| (Translocase of Outer Membrane) Located in Outer Mitochondrial Membrane. Proteins move into the intermembrane space through the TOM complex. Uses ATP |
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Term
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Definition
| (Translocase of Inner Membrane) Located in the Inner Mitochondrial Membrane. TIMs serve to translocate through inner membrane as well as facilitate the insertion of proteins into the inner mitochondrial membrane. |
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Term
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Definition
| Located in the intermembrane space, Tiny Tim proteins serve as both chaperone and shuttle proteins. |
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Term
| Mitochondrial Inheritance |
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Definition
| Genes are inherited entirely from the maternal side, segregate randomly at meiosis or mitosis, and are variably expressed. |
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Term
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Definition
| Dominant and Recessive alleles. Both parents give one copy, Dominant (if present) will be shown. |
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Term
| Proteins Imported to Mitochondrial Matrix |
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Definition
| Proteins unfolded and translocated by TOM. ETC establishes a proton gradient which helps move proteins through second translocon TIM. These proteins have a presequence of negatively charged amino acids, ATP used to 'ratchet' the protein into the matrix. Presequence is cleaved, and the protein is refolded. |
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Term
| Proteins Imported to Inner Mitochondrial Membrane |
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Definition
| Taken in by TOM, shuttled by Tiny Tim, placed in inner membrane by TIM. |
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Term
| Proteins to Outer Mitochondrial Membrane |
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Definition
| TOM used, requires ATP, chaperones (tiny tim) unfold and guide the proteins in cytosol and help refold after transfer. |
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